PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8184893-0 1994 Renin release from permeabilized juxtaglomerular cells is stimulated by chloride but not by low calcium. Chlorides 72-80 renin Rattus norvegicus 0-5 15283769-2 2004 The macula densa is involved in regulating afferent arteriolar tone and renin release by sensing alterations in luminal chloride via changes in the rate of Na(+)/K(+)/2Cl(-) cotransport, and administration of non-specific cyclooxygenase inhibitors will blunt increases in renin release mediated by macula densa sensing of decreases in luminal NaCl. Chlorides 120-128 renin Rattus norvegicus 72-77 15283769-2 2004 The macula densa is involved in regulating afferent arteriolar tone and renin release by sensing alterations in luminal chloride via changes in the rate of Na(+)/K(+)/2Cl(-) cotransport, and administration of non-specific cyclooxygenase inhibitors will blunt increases in renin release mediated by macula densa sensing of decreases in luminal NaCl. Chlorides 120-128 renin Rattus norvegicus 272-277 15283769-7 2004 Previous studies demonstrated that alterations in intraluminal chloride concentration are the signal for macula densa regulation of tubuloglomerular feedback and renin secretion, with high chloride stimulating tubuloglomerular feedback and low chloride stimulating renin release. Chlorides 63-71 renin Rattus norvegicus 162-167 15283769-10 2004 In isolated perfused glomerular preparations, renin release induced by macula densa perfusion with a low chloride solution was inhibited by a COX-2 inhibitor but not a COX-1 inhibitor. Chlorides 105-113 renin Rattus norvegicus 46-51 10555568-6 1999 On the assumption that the chloride equilibrium potential in renin-secreting cells is more positive than the membrane potential, our findings would suggest that the inhibitory effect of ANGII is enhanced when chloride entry is blocked and attenuated when chloride efflux is impaired. Chlorides 27-35 renin Rattus norvegicus 61-66 10555568-6 1999 On the assumption that the chloride equilibrium potential in renin-secreting cells is more positive than the membrane potential, our findings would suggest that the inhibitory effect of ANGII is enhanced when chloride entry is blocked and attenuated when chloride efflux is impaired. Chlorides 209-217 renin Rattus norvegicus 61-66 10555568-6 1999 On the assumption that the chloride equilibrium potential in renin-secreting cells is more positive than the membrane potential, our findings would suggest that the inhibitory effect of ANGII is enhanced when chloride entry is blocked and attenuated when chloride efflux is impaired. Chlorides 209-217 renin Rattus norvegicus 61-66 9353588-4 1997 Sodium or chloride depletion decreased plasma levels of atrial natriuretic peptide, increased plasma renin activity, and induced extracellular fluid volume contraction. Chlorides 10-18 renin Rattus norvegicus 101-106 7810695-3 1994 Lowering the extracellular chloride concentration by either of these maneuvers significantly enhanced renin secretion rates (RSR) at a perfusion pressure of 100 mmHg. Chlorides 27-35 renin Rattus norvegicus 102-107 9914402-1 1999 The cytosolic concentration of chloride correlates directly with renin secretion from renal juxtaglomerular granular (JG) cells. Chlorides 31-39 renin Rattus norvegicus 65-70 9914402-2 1999 In the present study, the mechanism by which chloride stimulates renin release was investigated in a preparation of permeabilized rat glomeruli with attached JG cells. Chlorides 45-53 renin Rattus norvegicus 65-70 9914402-3 1999 An isosmotic increase in the concentration of chloride by 129 mM stimulated renin release 16- to 20-fold. Chlorides 46-54 renin Rattus norvegicus 76-81 9914402-11 1999 The present data suggest that chloride stimulates renin release after entry of KCl into the renin secretory granules which results in swelling and release of renin. Chlorides 30-38 renin Rattus norvegicus 50-55 9914402-11 1999 The present data suggest that chloride stimulates renin release after entry of KCl into the renin secretory granules which results in swelling and release of renin. Chlorides 30-38 renin Rattus norvegicus 92-97 9914402-11 1999 The present data suggest that chloride stimulates renin release after entry of KCl into the renin secretory granules which results in swelling and release of renin. Chlorides 30-38 renin Rattus norvegicus 92-97 8184893-1 1994 The intracellular concentrations of calcium and chloride have been suggested to be involved in the control of renin secretion from juxtaglomerular (JG) cells. Chlorides 48-56 renin Rattus norvegicus 110-115 8184893-6 1994 Isosmotic increases in the chloride concentration to 25, 60, and 132 mM resulted in prompt stimulations of renin release. Chlorides 27-35 renin Rattus norvegicus 107-112 8184893-9 1994 We suggest that in intact JG cells an increase in calcium inhibits renin release through activation of chloride channels followed by a drop in the intracellular chloride concentration. Chlorides 103-111 renin Rattus norvegicus 67-72 8516350-2 1993 Within 2 weeks of initiation of dietary treatments, rats fed supplemental chloride had elevated blood pressure and lowered plasma renin activity, which persisted throughout the 8-week study. Chlorides 74-82 renin Rattus norvegicus 130-135 2331021-2 1990 Chloride depletion produced the most significant increase in plasma renin activity and extracellular fluid volume contraction. Chlorides 0-8 renin Rattus norvegicus 68-73 1558158-0 1992 Involvement of chloride in renin secretion from isolated rat glomeruli. Chlorides 15-23 renin Rattus norvegicus 27-32 1558158-7 1992 In May reintroduction of calcium and chloride stimulated renin release, suggesting that releasable renin had been stockpiled during the exposure to calcium-free solution. Chlorides 37-45 renin Rattus norvegicus 57-62 1558158-7 1992 In May reintroduction of calcium and chloride stimulated renin release, suggesting that releasable renin had been stockpiled during the exposure to calcium-free solution. Chlorides 37-45 renin Rattus norvegicus 99-104 1558158-8 1992 In September reintroduction of calcium and chloride inhibited renin release. Chlorides 43-51 renin Rattus norvegicus 62-67 2186635-1 1990 Inhibition of plasma renin activity (PRA) by saline has been shown to be related to a specific effect of chloride. Chlorides 105-113 renin Rattus norvegicus 21-26 2186635-2 1990 The purpose of this study was to test the hypothesis that inhibition of renin release by selective chloride infusion in the rat is related to increased chloride transport in the thick ascending limb of the loop of Henle (TALH). Chlorides 99-107 renin Rattus norvegicus 72-77 2186635-2 1990 The purpose of this study was to test the hypothesis that inhibition of renin release by selective chloride infusion in the rat is related to increased chloride transport in the thick ascending limb of the loop of Henle (TALH). Chlorides 152-160 renin Rattus norvegicus 72-77 2331021-9 1990 These results suggest different roles for sodium and chloride in the regulation of the peripheral and central renin-angiotensin system in young rats. Chlorides 53-61 renin Rattus norvegicus 110-115 3537461-2 1986 In the rat, we have shown that reduced chloride transport in the loop is associated with increased renin release. Chlorides 39-47 renin Rattus norvegicus 99-104 3537461-10 1986 These results demonstrate that an increase in loop chloride reabsorption is associated with a decrease in renin release. Chlorides 51-59 renin Rattus norvegicus 106-111 3537461-11 1986 This observation is consistent with the hypothesis that renin release is inversely related to the magnitude of chloride transport in the thick ascending limb of the loop of Henle. Chlorides 111-119 renin Rattus norvegicus 56-61 3521182-3 1986 Combined restriction of sodium, potassium and chloride elicited a decreased activity of the enzyme(s) involved in late steps in aldosterone biosynthesis, an elevation of plasma renin activity to excessively high levels and a substantial hypokalaemia. Chlorides 46-54 renin Rattus norvegicus 177-182 3018765-7 1986 In confirmation of earlier observations, inhibition of renin release by sodium chloride was related to chloride. Chlorides 79-87 renin Rattus norvegicus 55-60 3521182-2 1986 Treatment with a chloride-deficient diet led to a temporary decrease in the capsular adrenal conversions of corticosterone to 18-hydroxycorticosterone and aldosterone (manifest after 2 weeks but not longer apparent after 3 weeks), which was accompanied by a progressive rise in plasma renin activity and a moderate fall in plasma potassium. Chlorides 17-25 renin Rattus norvegicus 285-290 3521182-4 1986 Chloride repletion of these rats by the addition of NH4Cl or CaCl2 to their drinking fluid stimulated aldosterone biosynthesis while lowering plasma renin activity and raising plasma potassium. Chlorides 0-8 renin Rattus norvegicus 149-154 3901779-2 1985 The purpose of this study was to determine whether increased renin release is related to impaired absorptive chloride transport in the loop of Henle. Chlorides 109-117 renin Rattus norvegicus 61-66 3510973-0 1986 Effect of dietary chloride on salt-sensitive and renin-dependent hypertension. Chlorides 18-26 renin Rattus norvegicus 49-54 3510973-1 1986 We have previously reported that 1) selective dietary sodium loading (without chloride) does not produce hypertension in rats of the Dahl salt-sensitive strain (DS) and 2) selective chloride loading (without sodium) lowers plasma renin activity in the intact Sprague-Dawley rat maintained on a low NaCl diet. Chlorides 182-190 renin Rattus norvegicus 230-235 3901779-8 1985 Thus stimulation of renin release in adrenalectomized animals was associated with decreased absorptive chloride transport in the loop of Henle. Chlorides 103-111 renin Rattus norvegicus 20-25 6303178-0 1983 Effect of chloride on renin and blood pressure responses to sodium chloride. Chlorides 10-18 renin Rattus norvegicus 22-27 3903651-2 1985 Renin rose significantly as perfusate chloride fell; there was a sevenfold increase between perfusion with normal chloride and almost complete substitution of chloride by nitrate. Chlorides 38-46 renin Rattus norvegicus 0-5 3903651-2 1985 Renin rose significantly as perfusate chloride fell; there was a sevenfold increase between perfusion with normal chloride and almost complete substitution of chloride by nitrate. Chlorides 114-122 renin Rattus norvegicus 0-5 3903651-2 1985 Renin rose significantly as perfusate chloride fell; there was a sevenfold increase between perfusion with normal chloride and almost complete substitution of chloride by nitrate. Chlorides 114-122 renin Rattus norvegicus 0-5 3903651-4 1985 For all these experiments there was a significant negative correlation between renin and absolute tubular reabsorption of chloride (r = -0.68, P less than 0.001), but no such relationship with absolute sodium reabsorption. Chlorides 122-130 renin Rattus norvegicus 79-84 3903651-8 1985 We conclude that renin release is influenced by a signal dependent on, and inversely proportional to, chloride reabsorption in the thick ascending limb of the Loop of Henle. Chlorides 102-110 renin Rattus norvegicus 17-22 3903651-0 1985 Effect of reduced chloride reabsorption on renin release in the isolated rat kidney. Chlorides 18-26 renin Rattus norvegicus 43-48 3903651-1 1985 To investigate the relationship between tubular reabsorption of chloride and renal renin release in the isolated perfused rat kidney, perfusate renin activity was measured during substitution of either nitrate or thiocyanate for varying amounts of perfusate chloride but with maintained perfusate sodium concentration. Chlorides 64-72 renin Rattus norvegicus 83-88 6303178-4 1983 Plasma renin activity was stimulated by selective chloride depletion. Chlorides 50-58 renin Rattus norvegicus 7-12 6303178-7 1983 Thus, both the renin and possibly the blood pressure responses to sodium chloride are dependent on chloride. Chlorides 73-81 renin Rattus norvegicus 15-20 6337960-2 1983 We have previously suggested that inhibition of renin release by sodium chloride is related to absorptive chloride transport in the loop of Henle. Chlorides 72-80 renin Rattus norvegicus 48-53 7044145-1 1982 To evaluate the contribution of chloride to the suppression of plasma renin activity (PRA) by KCl, PRA was measured before and after venous infusions of KCl, KHCO3, KNO3, and KC2H3O2 in dietary NaCl-restricted rats. Chlorides 32-40 renin Rattus norvegicus 70-75 428074-0 1979 Stimulation of renin by acute selective chloride depletion in the rat. Chlorides 40-48 renin Rattus norvegicus 15-20 428074-16 1979 We conclude that acute selective chloride depletion per se is a potent stimulus for renin release. Chlorides 33-41 renin Rattus norvegicus 84-89 984192-8 1976 The failure of NaHCO3 and KHCO3 to inhibit renin suggests a role for chloride in mediating the renin responses to Na+ and K+. Chlorides 69-77 renin Rattus norvegicus 95-100 31796-0 1978 Importance of chloride for acute inhibition of renin by sodium chloride. Chlorides 14-22 renin Rattus norvegicus 47-52 31796-5 1978 These results suggest that inhibition of renin by sodium is dependent on an intrarenal effect of chloride. Chlorides 97-105 renin Rattus norvegicus 41-46 31796-7 1978 The association of renin inhibition and increased TcH2O indirectly supports the hypothesis that renin suppression by chloride is related to the magnitude of absorptive chloride transport in the thick ascending limb of the loop of Henle. Chlorides 117-125 renin Rattus norvegicus 19-24 31796-7 1978 The association of renin inhibition and increased TcH2O indirectly supports the hypothesis that renin suppression by chloride is related to the magnitude of absorptive chloride transport in the thick ascending limb of the loop of Henle. Chlorides 117-125 renin Rattus norvegicus 96-101 31796-7 1978 The association of renin inhibition and increased TcH2O indirectly supports the hypothesis that renin suppression by chloride is related to the magnitude of absorptive chloride transport in the thick ascending limb of the loop of Henle. Chlorides 168-176 renin Rattus norvegicus 19-24 31796-7 1978 The association of renin inhibition and increased TcH2O indirectly supports the hypothesis that renin suppression by chloride is related to the magnitude of absorptive chloride transport in the thick ascending limb of the loop of Henle. Chlorides 168-176 renin Rattus norvegicus 96-101 651121-0 1978 Contribution of chloride to the inhibition of plasma renin by sodium chloride in the rat. Chlorides 16-24 renin Rattus norvegicus 53-58