PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3059825-0 1988 Insulin increases loop segment chloride reabsorption in the euglycemic rat. Chlorides 31-39 insulin Homo sapiens 0-7 2676073-6 1989 Reagents such as chloride and phenol govern the conformations present in the insulin hexamers and this can influence the behaviour and properties of insulin preparations employing them. Chlorides 17-25 insulin Homo sapiens 77-84 2676073-6 1989 Reagents such as chloride and phenol govern the conformations present in the insulin hexamers and this can influence the behaviour and properties of insulin preparations employing them. Chlorides 17-25 insulin Homo sapiens 149-156 2650739-1 1989 The ionic strength dependence of the reaction rate between protein and dichloride anion radical has been investigated by flash photolysis of aqueous chloride-containing lysozyme, ribonuclease A, or insulin. Chlorides 73-81 insulin Homo sapiens 198-205 3059825-4 1988 Early distal chloride delivery decreased (P less than 0.001) during insulin administration. Chlorides 13-21 insulin Homo sapiens 68-75 3059825-5 1988 Insulin infusion increased calculated loop chloride reabsorption compared with both base-line values and values for time-control rats. Chlorides 43-51 insulin Homo sapiens 0-7 3059825-7 1988 We conclude that 1) euglycemic insulin administration reduces urinary chloride excretion in volume-expanded rats by tubular mechanisms; 2) in superficial nephrons, insulin has no effect on proximal tubule fluid or chloride reabsorption but markedly stimulates chloride reabsorption in the loop; and 3) chloride reabsorption in the distal convoluted tubule was unaltered by insulin administration. Chlorides 70-78 insulin Homo sapiens 31-38 5348493-6 1969 After insulin the rise of chloride was proportionately greater than the rise of hydrogen, so that neutral chloride was increased. Chlorides 26-34 insulin Homo sapiens 6-13 6390430-7 1984 Unlike the surface of the 2-zinc insulin hexamer, which possesses a shallow depression containing a zinc ion and its coordinating water molecules, the 4-zinc human insulin hexamer contains a zinc and chloride ion at the bottom of an 8-A tunnel produced by three parallel alpha-helices. Chlorides 200-208 insulin Homo sapiens 164-171 5348493-6 1969 After insulin the rise of chloride was proportionately greater than the rise of hydrogen, so that neutral chloride was increased. Chlorides 106-114 insulin Homo sapiens 6-13 5896907-0 1965 Insulin: preliminary x-ray studies of chloride crystals and a crystalline derivative. Chlorides 38-46 insulin Homo sapiens 0-7 28527712-8 2017 It also shows that zinc coordinates to histidine residues in an environment, which is similar to the coordination seen in the insulin R6 hexamers, where three histidine residues and a chloride ion is coordinating the zinc. Chlorides 184-192 insulin Homo sapiens 126-133 31561709-5 2021 METHOD: Experimental insulin adsorption data from literature is used to calculate insulin delivery and total insulin adsorption capacities for polyethylene (PE) and polyvinal chloride (PVC) lines at clinically relevant flow rates and concentrations. Chlorides 165-183 insulin Homo sapiens 21-28 31561709-5 2021 METHOD: Experimental insulin adsorption data from literature is used to calculate insulin delivery and total insulin adsorption capacities for polyethylene (PE) and polyvinal chloride (PVC) lines at clinically relevant flow rates and concentrations. Chlorides 185-188 insulin Homo sapiens 21-28 31561709-6 2021 RESULTS: Insulin adsorption capacity decreased hyperbolically with flow rate for both PE and PVC, where low flow scenarios result in greater insulin adherence to infusion lines. Chlorides 93-96 insulin Homo sapiens 9-16 32422433-1 2020 Chloride fluxes through the calcium-gated chloride channel Anoctamin-1 (TMEM16A) control blood pressure, secretion of saliva, mucin, insulin, and melatonin, gastrointestinal motility, sperm capacitation and motility, and pain sensation. Chlorides 0-8 insulin Homo sapiens 133-140 11408264-0 2001 Insulin and IGF-I inhibit calcium-dependent chloride secretion by T84 human colonic epithelial cells. Chlorides 44-52 insulin Homo sapiens 0-7 11408264-5 2001 Basolateral, but not apical, addition of insulin inhibited carbachol- and thapsigargin-induced chloride secretion in a time- and concentration-dependent fashion. Chlorides 95-103 insulin Homo sapiens 41-48 11408264-7 2001 Insulin had no effect on Ins(3,4,5,6)P(4) levels, and the inhibitory effects of insulin and IGF-I on chloride secretion were fully reversed by the PI 3-kinase inhibitors wortmannin and LY-294002. Chlorides 101-109 insulin Homo sapiens 80-87 11408264-9 2001 In conclusion, insulin and IGF-I act to inhibit calcium-dependent chloride secretion through a PI 3-kinase-dependent pathway. Chlorides 66-74 insulin Homo sapiens 15-22 24161582-8 2014 Some OC pesticides or PCBs, such as dichlorodiphenyltrichloroethanes (DDTs), chlordanes, and PCBs with 5 or less chlorides showed significant associations with diabetes or insulin resistance. Chlorides 113-122 insulin Homo sapiens 172-179 15649573-3 2005 Among parameters, body mass index (BMI), the fasting plasma glucose level (FPG), and plasma chloride concentration were identified by forward-stepwise discriminant analysis as parameters that can discriminate between patients who were and those who were not undergoing insulin therapy. Chlorides 92-100 insulin Homo sapiens 269-276 7589855-1 1995 Although chloride ions are known to modulate insulin release and islet electrical activity, the mechanism or mechanisms mediating these effects are unclear. Chlorides 9-17 insulin Homo sapiens 45-52