PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20438710-4 2010 Aldosterone also dose-dependently increased MCP-1, TGF-beta and type III collagen mRNA levels in MRC-5 cells, which were suppressed by nifedipine, but not amlodipine, a control calcium channel blocker. Nifedipine 135-145 C-C motif chemokine ligand 2 Homo sapiens 44-49 17408061-0 2007 Nifedipine, a calcium-channel blocker, inhibits advanced glycation end-product-induced expression of monocyte chemoattractant protein-1 in human cultured mesangial cells. Nifedipine 0-10 C-C motif chemokine ligand 2 Homo sapiens 101-135 18084847-2 2007 We have previously shown that nifedipine, one of the most popular DHPs, blocks tumour necrosis factor-alpha (TNF-alpha)-induced monocyte chemoattractant protein-1 as well as vascular cell adhesion molecule-1 (VCAM-1) expression in endothelial cells by suppressing reactive oxygen species generation (ROS). Nifedipine 30-40 C-C motif chemokine ligand 2 Homo sapiens 128-162 17408061-2 2007 This study investigated whether nifedipine, a widely used anti-hypertensive drug, suppresses expression of monocyte chemoattractant protein-1 (MCP-1), a chemokine that mediates the recruitment of monocytes to inflammatory sites, in AGE-exposed human cultured mesangial cells. Nifedipine 32-42 C-C motif chemokine ligand 2 Homo sapiens 107-141 17408061-2 2007 This study investigated whether nifedipine, a widely used anti-hypertensive drug, suppresses expression of monocyte chemoattractant protein-1 (MCP-1), a chemokine that mediates the recruitment of monocytes to inflammatory sites, in AGE-exposed human cultured mesangial cells. Nifedipine 32-42 C-C motif chemokine ligand 2 Homo sapiens 143-148 17408061-4 2007 AGEs significantly increased both MCP-1 mRNA expression and protein production in mesangial cells; this increase was blocked by both nifedipine and diphenylene iodonium. Nifedipine 133-143 C-C motif chemokine ligand 2 Homo sapiens 34-39 17408061-5 2007 These results suggest that nifedipine could play a protective role against early diabetic nephropathy by suppressing MCP-1 overexpression via blockade of AGE signalling in mesangial cells. Nifedipine 27-37 C-C motif chemokine ligand 2 Homo sapiens 117-122 15921025-8 2005 These results demonstrate that nifedipine could inhibit the TNF-alpha-induced upregulation of MCP-1 mRNA levels via suppression of CD40 expression in HUVEC. Nifedipine 31-41 C-C motif chemokine ligand 2 Homo sapiens 94-99 18200777-3 2006 Nifedipine inhibited MCP-1 expression by inhibiting nuclear factor (NF)-kappaB activation. Nifedipine 0-10 C-C motif chemokine ligand 2 Homo sapiens 21-26 15921025-0 2005 Nifedipine inhibits tumor necrosis factor-alpha-induced upregulation of monocyte chemoattractant protein-1 mRNA levels by suppressing CD40 expression in endothelial cells. Nifedipine 0-10 C-C motif chemokine ligand 2 Homo sapiens 72-106 15921025-2 2005 We have previously shown that nifedipine, one of the most popular DHPs, inhibits tumor necrosis factor-alpha (TNF-alpha)-induced reactive oxygen species generation and subsequent monocyte chemoattractant protein-1 (MCP-1) expression in human umbilical vein endothelial cells (HUVEC). Nifedipine 30-40 C-C motif chemokine ligand 2 Homo sapiens 179-213 15921025-2 2005 We have previously shown that nifedipine, one of the most popular DHPs, inhibits tumor necrosis factor-alpha (TNF-alpha)-induced reactive oxygen species generation and subsequent monocyte chemoattractant protein-1 (MCP-1) expression in human umbilical vein endothelial cells (HUVEC). Nifedipine 30-40 C-C motif chemokine ligand 2 Homo sapiens 215-220 15921025-5 2005 In this study, we investigated the involvement of CD40 in MCP-1 suppression by nifedipine in TNF-alpha-exposed HUVEC. Nifedipine 79-89 C-C motif chemokine ligand 2 Homo sapiens 58-63 15553663-3 2004 We have previously shown that nifedipine, one of the most popular dihydropyridine-based calcium antagonists, blocked tumor necrosis factor-alpha-induced monocyte chemoattractant protein-1 expression in endothelial cells (ECs) through its antioxidative properties. Nifedipine 30-40 C-C motif chemokine ligand 2 Homo sapiens 153-187 15553662-1 2004 We have previously shown that nifedipine, one of the most popular dihydropyridine-based calcium antagonists (DHPs), blocked tumor necrosis factor-alpha (TNF-alpha)-induced reactive oxygen species generation and subsequent monocyte chemoattractant protein-1 expression in endothelial cells (ECs), thus suggesting that nifedipine may inhibit monocyte recruitment, an initiating step in atherosclerosis. Nifedipine 30-40 C-C motif chemokine ligand 2 Homo sapiens 222-256 15018304-2 2003 We have very recently found that nifedipine, one of the most popularly used dihydropyridine-based calcium antagonists, prevented EC monocyte chemoattractant protein-1 production elicited by tumor necrosis factor-alpha (TNF-alpha through its antioxidative properties. Nifedipine 33-43 C-C motif chemokine ligand 2 Homo sapiens 132-166 15018305-0 2003 Nifedipine inhibits tumor necrosis factor-alpha-induced monocyte chemoattractant protein-1 overexpression by blocking NADPH oxidase-mediated reactive oxygen species generation. Nifedipine 0-10 C-C motif chemokine ligand 2 Homo sapiens 56-90 15018305-4 2003 In this study, we investigated whether nifedipine, one of the most popular DHPs, could inhibit tumor necrosis factor-alpha (TNF-alpha)-induced reactive oxygen species (ROS) generation and subsequent monocyte chemoattractant protein-1 (MCP-1) expression in human umbilical vein endothelial cells (HUVEC). Nifedipine 39-49 C-C motif chemokine ligand 2 Homo sapiens 199-233 15018305-4 2003 In this study, we investigated whether nifedipine, one of the most popular DHPs, could inhibit tumor necrosis factor-alpha (TNF-alpha)-induced reactive oxygen species (ROS) generation and subsequent monocyte chemoattractant protein-1 (MCP-1) expression in human umbilical vein endothelial cells (HUVEC). Nifedipine 39-49 C-C motif chemokine ligand 2 Homo sapiens 235-240 15018305-7 2003 Furthermore, nifedipine was found to significantly inhibit upregulation of MCP-1 messenger RNA levels in TNF-alpha-exposed HUVEC. Nifedipine 13-23 C-C motif chemokine ligand 2 Homo sapiens 75-80 15018305-8 2003 The results demonstrate that nifedipine could inhibit TNF-alpha-induced MCP-1 overexpression in HUVEC by suppressing NADPH oxidase-mediated ROS generation. Nifedipine 29-39 C-C motif chemokine ligand 2 Homo sapiens 72-77 10725264-13 2000 These findings suggest that 1,4-dihydropyridines such as nifedipine affect the expression of both potentially pro-arteriosclerotic (MCP-1) and anti-arteriosclerotic (iNOS) gene products in the vessel wall at the level of transcription, and that these effects are unrelated to their calcium channel-blocking properties. Nifedipine 57-67 C-C motif chemokine ligand 2 Homo sapiens 132-137