PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19116182-0	2009	CB1 receptor knockout mice are hyporesponsive to the behavior-stimulating actions of d-amphetamine: role of mGlu5 receptors.	Dextroamphetamine	85-98	cannabinoid receptor 1 (brain)	Mus musculus	0-3	
19116182-2	2009	The CB1R antagonist SR141716A dose-dependently decreased d-amphetamine-induced hyperactivity.Also, d-amphetamine-induced hyperlocomotion was reduced in CB1R knockout (KO) mice.	Dextroamphetamine	57-70	cannabinoid receptor 1 (brain)	Mus musculus	4-8	
19116182-2	2009	The CB1R antagonist SR141716A dose-dependently decreased d-amphetamine-induced hyperactivity.Also, d-amphetamine-induced hyperlocomotion was reduced in CB1R knockout (KO) mice.	Dextroamphetamine	57-70	cannabinoid receptor 1 (brain)	Mus musculus	152-156	
19116182-2	2009	The CB1R antagonist SR141716A dose-dependently decreased d-amphetamine-induced hyperactivity.Also, d-amphetamine-induced hyperlocomotion was reduced in CB1R knockout (KO) mice.	Dextroamphetamine	99-112	cannabinoid receptor 1 (brain)	Mus musculus	4-8	
19116182-2	2009	The CB1R antagonist SR141716A dose-dependently decreased d-amphetamine-induced hyperactivity.Also, d-amphetamine-induced hyperlocomotion was reduced in CB1R knockout (KO) mice.	Dextroamphetamine	99-112	cannabinoid receptor 1 (brain)	Mus musculus	152-156	
19116182-3	2009	However, CB1R KO and wild-type mice showed a similar d-amphetamine-induced increase in nucleus accumbens DA release.	Dextroamphetamine	53-66	cannabinoid receptor 1 (brain)	Mus musculus	9-13	
19116182-6	2009	Thus, hyporesponsiveness to the psychostimulant effects of d-amphetamine as a result of CB1R antagonism/invalidation is not due to an ensuing decrease in d-amphetamine-induced DA release in the nucleus accumbens, but rather due to a hyperglutamatergic state and facilitation of glutamatergic neurotransmission at the mGlu5, but not NMDA, receptors.	Dextroamphetamine	59-72	cannabinoid receptor 1 (brain)	Mus musculus	88-92	
17596442-5	2007	Locomotor responses to cocaine and D-amphetamine were decreased in CB1-R-deficient mice, and sensitization was impaired.	Dextroamphetamine	35-48	cannabinoid receptor 1 (brain)	Mus musculus	67-70	
11163634-6	2001	The specificity of such interaction is supported by the finding that contrary to morphine, cocaine, d-amphetamine and nicotine were self-administered by mice at the same extent either in presence or in absence of the CB1 receptor.	Dextroamphetamine	100-113	cannabinoid receptor 1 (brain)	Mus musculus	217-220