PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26871939-7 2016 Zif-268 was increased in the striatum of rats treated with l-dopa and l-dopa plus preladenant compared with vehicle. Levodopa 59-65 early growth response 1 Rattus norvegicus 0-7 33050305-8 2020 L-DOPA treatment drastically increased the expression of dynorphin (direct pathway), 5-HT1B, and zif268 mRNA in the striatum ipsilateral to the lesion. Levodopa 0-6 early growth response 1 Rattus norvegicus 97-103 34229013-6 2021 Evaluation of immediate-early-gene zif-268 (index of neuronal activation) after l-dopa challenge, showed an increase in its expression in denervated CPu of rats pretreated with l-dopa or l-dopa plus preladenant compared with vehicle, whereas rats pretreated with eltoprazine, with or without preladenant, had lower zif-268-expression. Levodopa 80-86 early growth response 1 Rattus norvegicus 35-42 34229013-6 2021 Evaluation of immediate-early-gene zif-268 (index of neuronal activation) after l-dopa challenge, showed an increase in its expression in denervated CPu of rats pretreated with l-dopa or l-dopa plus preladenant compared with vehicle, whereas rats pretreated with eltoprazine, with or without preladenant, had lower zif-268-expression. Levodopa 80-86 early growth response 1 Rattus norvegicus 315-322 34229013-6 2021 Evaluation of immediate-early-gene zif-268 (index of neuronal activation) after l-dopa challenge, showed an increase in its expression in denervated CPu of rats pretreated with l-dopa or l-dopa plus preladenant compared with vehicle, whereas rats pretreated with eltoprazine, with or without preladenant, had lower zif-268-expression. Levodopa 177-183 early growth response 1 Rattus norvegicus 35-42 34229013-6 2021 Evaluation of immediate-early-gene zif-268 (index of neuronal activation) after l-dopa challenge, showed an increase in its expression in denervated CPu of rats pretreated with l-dopa or l-dopa plus preladenant compared with vehicle, whereas rats pretreated with eltoprazine, with or without preladenant, had lower zif-268-expression. Levodopa 187-193 early growth response 1 Rattus norvegicus 35-42 26871939-7 2016 Zif-268 was increased in the striatum of rats treated with l-dopa and l-dopa plus preladenant compared with vehicle. Levodopa 70-76 early growth response 1 Rattus norvegicus 0-7 26871939-8 2016 In contrast, rats treated with eltoprazine (with or without preladenant) had lower zif-268 activation after chronic treatment in both the dyskinetic and l-dopa-non-primed groups. Levodopa 153-159 early growth response 1 Rattus norvegicus 83-90 21507338-0 2011 Differential expression of FosB, c-Fos, and Zif268 in forebrain regions after acute or chronic L-DOPA treatment in a rat model of Parkinson"s disease. Levodopa 95-101 early growth response 1 Rattus norvegicus 44-50 25442003-1 2016 BACKGROUND: A systematic search of brain nuclei putatively involved in L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID) in Parkinson"s disease shed light, notably, upon the lateral habenula (LHb), which displayed an overexpression of the FosB, ARC, and Zif268 immediate-early genes only in rats experiencing abnormal involuntary movements (AIMs). Levodopa 71-99 early growth response 1 Rattus norvegicus 268-274 25442003-1 2016 BACKGROUND: A systematic search of brain nuclei putatively involved in L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID) in Parkinson"s disease shed light, notably, upon the lateral habenula (LHb), which displayed an overexpression of the FosB, ARC, and Zif268 immediate-early genes only in rats experiencing abnormal involuntary movements (AIMs). Levodopa 101-107 early growth response 1 Rattus norvegicus 268-274 21507338-1 2011 A study was carried out to examine the effects of acute and chronic L-DOPA treatment on the distribution of the immediate-early gene (IEG) proteins (FosB, c-Fos, and Zif268) in forebrain regions in a unilateral 6-hydroxydopamine (6-OHDA) rat model of Parkinson"s disease. Levodopa 68-74 early growth response 1 Rattus norvegicus 166-172 18583175-5 2008 Zif-268 mRNA levels were decreased in both striatonigral and striatopallidal neurons by ropinirole, in contrast to hyper-expression of zif-268 mRNA selectively induced by L-dopa in striatonigral neurons. Levodopa 171-177 early growth response 1 Rattus norvegicus 135-142 15813929-2 2005 The effects of acute and subchronic L-DOPA administration on zif-268 mRNA expression were compared in 6-hydroxydopamine-lesioned rats. Levodopa 36-42 early growth response 1 Rattus norvegicus 61-68 15813929-4 2005 Three days after interruption of subchronic treatment, zif-268 mRNA was evaluated after an L-DOPA challenge. Levodopa 91-97 early growth response 1 Rattus norvegicus 55-62 15813929-5 2005 Zif-268 mRNA levels increased in the lesioned dorsolateral striatum after either acute or subchronic L-DOPA administration. Levodopa 101-107 early growth response 1 Rattus norvegicus 0-7 15813929-7 2005 Single acute L-DOPA significantly increased zif-268 in all striatal neurons reflecting a hyperresponsiveness of dopamine-depleted striatum. Levodopa 13-19 early growth response 1 Rattus norvegicus 44-51 15813929-8 2005 After subchronic L-DOPA, zif-268 mRNA labelling was still increased in the striatonigral pathway, limited to dynorphin(+) neurons, whereas in all other neurons it was similar to the control value. Levodopa 17-23 early growth response 1 Rattus norvegicus 25-32