PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33050305-8	2020	L-DOPA treatment drastically increased the expression of dynorphin (direct pathway), 5-HT1B, and zif268 mRNA in the striatum ipsilateral to the lesion.	Levodopa	0-6	early growth response 1	Rattus norvegicus	97-103	
26871939-7	2016	Zif-268 was increased in the striatum of rats treated with l-dopa and l-dopa plus preladenant compared with vehicle.	Levodopa	59-65	early growth response 1	Rattus norvegicus	0-7	
26871939-7	2016	Zif-268 was increased in the striatum of rats treated with l-dopa and l-dopa plus preladenant compared with vehicle.	Levodopa	70-76	early growth response 1	Rattus norvegicus	0-7	
26871939-8	2016	In contrast, rats treated with eltoprazine (with or without preladenant) had lower zif-268 activation after chronic treatment in both the dyskinetic and l-dopa-non-primed groups.	Levodopa	153-159	early growth response 1	Rattus norvegicus	83-90	
25442003-1	2016	BACKGROUND: A systematic search of brain nuclei putatively involved in L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID) in Parkinson"s disease shed light, notably, upon the lateral habenula (LHb), which displayed an overexpression of the  FosB, ARC, and Zif268 immediate-early genes only in rats experiencing abnormal involuntary movements (AIMs).	Levodopa	71-99	early growth response 1	Rattus norvegicus	268-274	
25442003-1	2016	BACKGROUND: A systematic search of brain nuclei putatively involved in L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID) in Parkinson"s disease shed light, notably, upon the lateral habenula (LHb), which displayed an overexpression of the  FosB, ARC, and Zif268 immediate-early genes only in rats experiencing abnormal involuntary movements (AIMs).	Levodopa	101-107	early growth response 1	Rattus norvegicus	268-274	
18583175-5	2008	Zif-268 mRNA levels were decreased in both striatonigral and striatopallidal neurons by ropinirole, in contrast to hyper-expression of zif-268 mRNA selectively induced by L-dopa in striatonigral neurons.	Levodopa	171-177	early growth response 1	Rattus norvegicus	135-142	
15813929-2	2005	The effects of acute and subchronic L-DOPA administration on zif-268 mRNA expression were compared in 6-hydroxydopamine-lesioned rats.	Levodopa	36-42	early growth response 1	Rattus norvegicus	61-68	
15813929-4	2005	Three days after interruption of subchronic treatment, zif-268 mRNA was evaluated after an L-DOPA challenge.	Levodopa	91-97	early growth response 1	Rattus norvegicus	55-62	
15813929-5	2005	Zif-268 mRNA levels increased in the lesioned dorsolateral striatum after either acute or subchronic L-DOPA administration.	Levodopa	101-107	early growth response 1	Rattus norvegicus	0-7	
15813929-7	2005	Single acute L-DOPA significantly increased zif-268 in all striatal neurons reflecting a hyperresponsiveness of dopamine-depleted striatum.	Levodopa	13-19	early growth response 1	Rattus norvegicus	44-51	
15813929-8	2005	After subchronic L-DOPA, zif-268 mRNA labelling was still increased in the striatonigral pathway, limited to dynorphin(+) neurons, whereas in all other neurons it was similar to the control value.	Levodopa	17-23	early growth response 1	Rattus norvegicus	25-32	
34229013-6	2021	Evaluation of immediate-early-gene zif-268 (index of neuronal activation) after l-dopa challenge, showed an increase in its expression in denervated CPu of rats pretreated with l-dopa or l-dopa plus preladenant compared with vehicle, whereas rats pretreated with eltoprazine, with or without preladenant, had lower zif-268-expression.	Levodopa	80-86	early growth response 1	Rattus norvegicus	35-42	
34229013-6	2021	Evaluation of immediate-early-gene zif-268 (index of neuronal activation) after l-dopa challenge, showed an increase in its expression in denervated CPu of rats pretreated with l-dopa or l-dopa plus preladenant compared with vehicle, whereas rats pretreated with eltoprazine, with or without preladenant, had lower zif-268-expression.	Levodopa	80-86	early growth response 1	Rattus norvegicus	315-322	
34229013-6	2021	Evaluation of immediate-early-gene zif-268 (index of neuronal activation) after l-dopa challenge, showed an increase in its expression in denervated CPu of rats pretreated with l-dopa or l-dopa plus preladenant compared with vehicle, whereas rats pretreated with eltoprazine, with or without preladenant, had lower zif-268-expression.	Levodopa	177-183	early growth response 1	Rattus norvegicus	35-42	
34229013-6	2021	Evaluation of immediate-early-gene zif-268 (index of neuronal activation) after l-dopa challenge, showed an increase in its expression in denervated CPu of rats pretreated with l-dopa or l-dopa plus preladenant compared with vehicle, whereas rats pretreated with eltoprazine, with or without preladenant, had lower zif-268-expression.	Levodopa	187-193	early growth response 1	Rattus norvegicus	35-42	
21507338-0	2011	Differential expression of FosB, c-Fos, and Zif268 in forebrain regions after acute or chronic L-DOPA treatment in a rat model of Parkinson"s disease.	Levodopa	95-101	early growth response 1	Rattus norvegicus	44-50	
21507338-1	2011	A study was carried out to examine the effects of acute and chronic L-DOPA treatment on the distribution of the immediate-early gene (IEG) proteins (FosB, c-Fos, and Zif268) in forebrain regions in a unilateral 6-hydroxydopamine (6-OHDA) rat model of Parkinson"s disease.	Levodopa	68-74	early growth response 1	Rattus norvegicus	166-172