PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30404141-3	2018	Due to the stabilisation of an i-motif structure by the choline cation, a unique fluorescence emission-that was not seen in an aqueous buffer-was observed in choline dhp and remained stable for more than 30 days.	Choline	56-63	dihydropyrimidinase	Homo sapiens	166-169	
30404141-3	2018	Due to the stabilisation of an i-motif structure by the choline cation, a unique fluorescence emission-that was not seen in an aqueous buffer-was observed in choline dhp and remained stable for more than 30 days.	Choline	158-165	dihydropyrimidinase	Homo sapiens	166-169	
30404141-5	2018	A turn-on sensing platform in choline dhp was built for the detection of the BRCA1 gene, which is related to familial breast and ovarian cancers.	Choline	30-37	dihydropyrimidinase	Homo sapiens	38-41	
30404141-6	2018	This platform showed better sensitivity and selectivity in distinguishing a target sequence from a mutant sequence in choline dhp than in the aqueous buffer.	Choline	118-125	dihydropyrimidinase	Homo sapiens	126-129	
25919083-3	2015	Mismatched base pairs were significantly destabilized in choline dhp relative to those in aqueous buffer.	Choline	57-64	dihydropyrimidinase	Homo sapiens	65-68	
25919083-6	2015	Moreover, the molecular beacon was protected from a contaminating nuclease in choline dhp, and DNAs in aqueous solutions were not sufficiently stable for practical use.	Choline	78-85	dihydropyrimidinase	Homo sapiens	86-89	
23758528-5	2013	We have added choline dihydrogen phosphate (choline dhp) into this study on the basis of positive results from previously reported protein folding studies using this ionic liquid.	Choline	14-21	dihydropyrimidinase	Homo sapiens	52-55	
25738708-1	2015	Thermodynamic analyses and molecular dynamics calculations demonstrated that i-motifs in a hydrated ionic liquid of choline dihydrogen phosphate (choline dhp) were more stable than G-quadruplexes due to choline ion binding to loop regions in the i-motifs.	Choline	116-123	dihydropyrimidinase	Homo sapiens	154-157	
25738708-1	2015	Thermodynamic analyses and molecular dynamics calculations demonstrated that i-motifs in a hydrated ionic liquid of choline dihydrogen phosphate (choline dhp) were more stable than G-quadruplexes due to choline ion binding to loop regions in the i-motifs.	Choline	146-153	dihydropyrimidinase	Homo sapiens	154-157	
25738708-2	2015	Interestingly, the i-motifs formed even at physiological pH in the choline dhp-containing solution.	Choline	67-74	dihydropyrimidinase	Homo sapiens	75-78	
25013178-4	2014	Hydrated ILs, such as choline dihydrogen phosphate (choline dhp) and deep eutectic solvent (DES) prepared from choline chloride and urea, are "green" solvents that ensure long-term stability of biomolecules.	Choline	22-29	dihydropyrimidinase	Homo sapiens	60-63	
25013178-6	2014	We here review current knowledge about the structures and stabilities of nucleic acids in choline dhp and DES.	Choline	90-97	dihydropyrimidinase	Homo sapiens	98-101	
25013178-7	2014	Interestingly, in choline dhp, A-T base pairs are more stable than G-C base pairs, the reverse of the situation in buffered NaCl solution.	Choline	18-25	dihydropyrimidinase	Homo sapiens	26-29	
25013178-9	2014	In choline dhp, the stability of Hoogsteen base pairs is comparable to that of Watson-Crick base pairs.	Choline	3-10	dihydropyrimidinase	Homo sapiens	11-14	
20680198-1	2010	Mixtures of the plastic crystal material choline dihydrogen phosphate [Choline][DHP] and phosphoric acid, from 4.5 mol% to 18 mol% H(3)PO(4), were investigated and shown to have significantly higher proton conductivity compared to the pure [Choline][DHP].	Choline	71-78	dihydropyrimidinase	Homo sapiens	80-83	
20680198-3	2010	The ionic conductivity was observed to increase by more than an order of magnitude in phase I (i.e. the highest temperature solid phase in [Choline][DHP]) reaching up to 10(-2) S cm(-1).	Choline	140-147	dihydropyrimidinase	Homo sapiens	149-152