PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30404141-3 2018 Due to the stabilisation of an i-motif structure by the choline cation, a unique fluorescence emission-that was not seen in an aqueous buffer-was observed in choline dhp and remained stable for more than 30 days. Choline 56-63 dihydropyrimidinase Homo sapiens 166-169 30404141-3 2018 Due to the stabilisation of an i-motif structure by the choline cation, a unique fluorescence emission-that was not seen in an aqueous buffer-was observed in choline dhp and remained stable for more than 30 days. Choline 158-165 dihydropyrimidinase Homo sapiens 166-169 30404141-5 2018 A turn-on sensing platform in choline dhp was built for the detection of the BRCA1 gene, which is related to familial breast and ovarian cancers. Choline 30-37 dihydropyrimidinase Homo sapiens 38-41 30404141-6 2018 This platform showed better sensitivity and selectivity in distinguishing a target sequence from a mutant sequence in choline dhp than in the aqueous buffer. Choline 118-125 dihydropyrimidinase Homo sapiens 126-129 25919083-3 2015 Mismatched base pairs were significantly destabilized in choline dhp relative to those in aqueous buffer. Choline 57-64 dihydropyrimidinase Homo sapiens 65-68 25919083-6 2015 Moreover, the molecular beacon was protected from a contaminating nuclease in choline dhp, and DNAs in aqueous solutions were not sufficiently stable for practical use. Choline 78-85 dihydropyrimidinase Homo sapiens 86-89 23758528-5 2013 We have added choline dihydrogen phosphate (choline dhp) into this study on the basis of positive results from previously reported protein folding studies using this ionic liquid. Choline 14-21 dihydropyrimidinase Homo sapiens 52-55 25738708-1 2015 Thermodynamic analyses and molecular dynamics calculations demonstrated that i-motifs in a hydrated ionic liquid of choline dihydrogen phosphate (choline dhp) were more stable than G-quadruplexes due to choline ion binding to loop regions in the i-motifs. Choline 116-123 dihydropyrimidinase Homo sapiens 154-157 25738708-1 2015 Thermodynamic analyses and molecular dynamics calculations demonstrated that i-motifs in a hydrated ionic liquid of choline dihydrogen phosphate (choline dhp) were more stable than G-quadruplexes due to choline ion binding to loop regions in the i-motifs. Choline 146-153 dihydropyrimidinase Homo sapiens 154-157 25738708-2 2015 Interestingly, the i-motifs formed even at physiological pH in the choline dhp-containing solution. Choline 67-74 dihydropyrimidinase Homo sapiens 75-78 25013178-4 2014 Hydrated ILs, such as choline dihydrogen phosphate (choline dhp) and deep eutectic solvent (DES) prepared from choline chloride and urea, are "green" solvents that ensure long-term stability of biomolecules. Choline 22-29 dihydropyrimidinase Homo sapiens 60-63 25013178-6 2014 We here review current knowledge about the structures and stabilities of nucleic acids in choline dhp and DES. Choline 90-97 dihydropyrimidinase Homo sapiens 98-101 25013178-7 2014 Interestingly, in choline dhp, A-T base pairs are more stable than G-C base pairs, the reverse of the situation in buffered NaCl solution. Choline 18-25 dihydropyrimidinase Homo sapiens 26-29 25013178-9 2014 In choline dhp, the stability of Hoogsteen base pairs is comparable to that of Watson-Crick base pairs. Choline 3-10 dihydropyrimidinase Homo sapiens 11-14 20680198-1 2010 Mixtures of the plastic crystal material choline dihydrogen phosphate [Choline][DHP] and phosphoric acid, from 4.5 mol% to 18 mol% H(3)PO(4), were investigated and shown to have significantly higher proton conductivity compared to the pure [Choline][DHP]. Choline 71-78 dihydropyrimidinase Homo sapiens 80-83 20680198-3 2010 The ionic conductivity was observed to increase by more than an order of magnitude in phase I (i.e. the highest temperature solid phase in [Choline][DHP]) reaching up to 10(-2) S cm(-1). Choline 140-147 dihydropyrimidinase Homo sapiens 149-152