PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35630613-2 2022 Inhibition of AChE slows down the hydrolysis of acetycholine and increases choline levels, improving the cognitive function. Choline 75-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-18 34395382-4 2021 Furthermore, based on this catalytic reaction, taken together with the two enzymatic catalytic systems of acetylcholinesterase (AChE) and choline oxidase (CHO), a highly sensitive multi-catalytic sensing system could be successfully developed for organophosphorus (OPs) pesticides such as dimethoate, DDVP, and parathion-methyl. Choline 138-145 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 35507043-6 2022 They exhibited choline-mimetic potential, such as compound 23, 31 and 44 inhibited AChE enzyme (IC50 value of 240, 174, and 134 microM, respectively) and BChE enzyme (IC50 value of 203, 134 and 97 microM, respectively). Choline 15-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 6191833-1 1983 The possibility that cholinergic neurons of the basal forebrain project to the spinal cord was investigated utilizing the retrograde transport of bisbenzimide and [3H]choline as well as acetylcholinesterase histochemistry. Choline 21-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 186-206 35208411-1 2022 According to the current model of nerve propagation, the function of acetylcholinesterase (AChE) is to terminate synaptic transmission of nerve signals by hydrolyzing the neurotransmitter acetylcholine (ACh) in the synaptic cleft to acetic acid (acetate) and choline. Choline 259-266 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-89 35208411-1 2022 According to the current model of nerve propagation, the function of acetylcholinesterase (AChE) is to terminate synaptic transmission of nerve signals by hydrolyzing the neurotransmitter acetylcholine (ACh) in the synaptic cleft to acetic acid (acetate) and choline. Choline 259-266 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 3977858-6 1985 The acetylcholinesterase activity is measured by monitoring the increase in light emission produced by the accumulation of choline or by determining the amount of choline generated after a short interval. Choline 123-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 2761299-2 1989 The assay is based upon the reactions: (1) hydrolysis of acetylcholine to choline and acetate, catalyzed by acetylcholinesterase. Choline 63-70 acetylcholinesterase (Cartwright blood group) Homo sapiens 108-128 3220975-3 1988 Concurrent histochemical and immunological staining demonstrated that all choline-acetyltransferase-positive NB neurons in the human brain also contain acetylcholinesterase enzyme activity. Choline 74-81 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 3942870-3 1986 The decrease in AChE activity was correlated with a decrease in choline acetyltransferase activity thought to reflect lesion of cholinergic neurones in the substantia innominata which innervate the cerebral cortex. Choline 64-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 20493110-2 1986 Acetylcholine and choline are first separated by HPLC then react in a mini-column with acetylcholinesterase and choline oxidase immobilized on Sepharose. Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 6780228-2 1980 Acetylcholine is hydrolysed by acetylcholinesterase; the choline liberated is oxidized by choline oxidase to betaine; the H2O2 generated triggers the luminescence of luminol in presence of peroxidase. Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 31-51 177158-8 1975 It is concluded that acetylcholinesterase (EC 3.1.1.7) of red cells rapidly hydrolyzes acetylcholine mustard aziridinium ion to acetate and choline mustard aziridinium and the latter compound can act as a potent inhibitor of choline transport. Choline 93-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 33186817-3 2021 This is because that MnO2 NS have oxidized characteristic, and they can react with choline (TCh), which is the product of acetylthiocholine (ATCh) catalyzed by acetylcholinesterase (AChE). Choline 83-90 acetylcholinesterase (Cartwright blood group) Homo sapiens 182-186 33427318-7 2021 AChE converts acetylcholine into choline and acetic acid, thus causing the return of a cholinergic neuron to its resting state. Choline 20-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 33529929-4 2021 On the other hand, AChE can catalyze the hydrolysis of Myr into choline and myristic acid. Choline 64-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 33936095-3 2021 The cholinergic system includes the neurotransmitter\ molecule, acetylcholine (ACh), cholinergic receptors (AChRs), choline acetyltransferase (ChAT) enzyme, and acetylcholinesterase (AChE) enzyme. Choline 4-11 acetylcholinesterase (Cartwright blood group) Homo sapiens 183-187 32096991-2 2020 AChE is important for neurotransmission at neuromuscular junctions and cholinergic brain synapses by hydrolyzing acetylcholine into acetate and choline. Choline 71-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 32827859-3 2021 In the double-enzymes reactions, acetylcholine chloride (ACh) can be catalyzed to produce choline by AChE, which is successively hydrolyzed to betaine and hydrogen peroxide (H2O2) by CHO. Choline 39-46 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 33038610-1 2020 Acetylcholinesterase (AChE) hydrolyses acetylcholine to choline and acetate, playing an important role in terminating the neurotransmission in brain and muscle. Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 31550630-4 2019 In the absence of OPs, acetylcholinesterase (AChE) hydrolyzed acetylcholine chloride (ATCh) into choline (TCh) and acetate. Choline 29-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 32053129-5 2020 Under the catalysis of acetylcholinesterase (AChE) and choline oxidase (CHO), H2O2 was produced by using acetylcholine chloride (ACh) as a substrate, which was sensitive to the proposed CL system. Choline 29-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 45-49 31902355-11 2020 AChE hydrolyses of ACh to acetate and choline as an important neurotransmitter substance. Choline 38-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 30291908-2 2019 Several lines of evidence show that lung cancer cells express all of the proteins required for the uptake of choline (choline transporter 1, choline transporter-like proteins) synthesis of ACh (choline acetyltransferase, carnitine acetyltransferase), transport of ACh (vesicular acetylcholine transport, OCTs, OCTNs) and degradation of ACh (acetylcholinesterase, butyrylcholinesterase). Choline 109-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 189-192 31100281-5 2019 Docking studies revealed that the quinoline group within the AChE active site was positioned in the choline binding site, while the C(4)-amino group substituents, depending on their lipophilicity, could establish hydrogen bonds or pi-interactions with residues of the peripheral anionic site. Choline 100-107 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-65 32255162-2 2019 Herein, we designed a colorimetric strategy for the facile and accurate detection of AChE based on tandem catalysis with a multi-enzyme system, which is constituted by cobalt oxyhydroxide nanoflakes (CoOOH NFs) and choline oxidase (CHO). Choline 215-222 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 32255162-3 2019 In this sensor, AChE catalytically hydrolyzed acetylcholine (ACh) to produce choline, which was further efficiently oxidized by CHO to yield H2O2. Choline 52-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 31615442-6 2019 Expression of acetylcholinesterase (AChE) and choline acetyltransferase (ChAT) was measured by quantitative real-time PCR and western blot. Choline 20-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 31532667-5 2019 Upon the addition of AChE and choline oxidase, acetylcholine was catalyzed to produce choline that was further oxidized to produce H2O2. Choline 53-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-25 30823604-1 2019 Acetylcholinesterase (AChE) catalyzes the hydrolysis of neurotransmitter acetylcholine to acetate and choline in a synaptic cleft. Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 30291908-2 2019 Several lines of evidence show that lung cancer cells express all of the proteins required for the uptake of choline (choline transporter 1, choline transporter-like proteins) synthesis of ACh (choline acetyltransferase, carnitine acetyltransferase), transport of ACh (vesicular acetylcholine transport, OCTs, OCTNs) and degradation of ACh (acetylcholinesterase, butyrylcholinesterase). Choline 109-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 264-267 30291908-2 2019 Several lines of evidence show that lung cancer cells express all of the proteins required for the uptake of choline (choline transporter 1, choline transporter-like proteins) synthesis of ACh (choline acetyltransferase, carnitine acetyltransferase), transport of ACh (vesicular acetylcholine transport, OCTs, OCTNs) and degradation of ACh (acetylcholinesterase, butyrylcholinesterase). Choline 109-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 264-267 30291908-2 2019 Several lines of evidence show that lung cancer cells express all of the proteins required for the uptake of choline (choline transporter 1, choline transporter-like proteins) synthesis of ACh (choline acetyltransferase, carnitine acetyltransferase), transport of ACh (vesicular acetylcholine transport, OCTs, OCTNs) and degradation of ACh (acetylcholinesterase, butyrylcholinesterase). Choline 109-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 341-361 29934672-5 2018 Compounds with para-substituted chalcone fragments in which the substituents were choline-like had potent activity against AChE and poor activity against BChE, while ortho-substituted analogs exhibited an opposite effect. Choline 82-89 acetylcholinesterase (Cartwright blood group) Homo sapiens 123-127 29934672-9 2018 Overall, the results show that coumarin-chalcone hybrids with choline-like side-chains have promising activity and selectivity against AChE and be promising therapeutic leads for Alzheimer"s disease. Choline 62-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 135-139 28106328-1 2017 Acetylcholinesterase (AChE), an enzyme of the serine hydrolase superfamily, is a mediator of signal transmission at cholinergic synapses by catalyzing acetylcholine cleavage into acetate and choline. Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 30008113-2 2018 The rapid hydrolysis of the principal neurotransmitter into choline and acetate by acetylcholinesterase (AChE) at synapses causes the loss of cognitive response that becomes the real cause of AD. Choline 60-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 30008113-2 2018 The rapid hydrolysis of the principal neurotransmitter into choline and acetate by acetylcholinesterase (AChE) at synapses causes the loss of cognitive response that becomes the real cause of AD. Choline 60-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 105-109 29550345-1 2018 Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are key cholinesterase enzymes responsible for the hydrolysis of acetylcholine into choline and acetic acid, an essential process for the restoration of the cholinergic neuron. Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 29623856-9 2018 Choline uptake inhibition by hemicholinium did increase the AChE activity but not in the erythroid differentiated K562 cell line. Choline 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-64 29567174-2 2018 This sensing strategy involves the reaction of acetylcholine chloride (ACh) with acetylcholinesterase (AChE) to form choline that is in turn catalytically oxidized by choline oxidase (ChOx) to produce hydrogen peroxide (H2O2), thus L-Cys-Ag(I) CP possesses the electro-catalytic property to H2O2 reduction. Choline 53-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 29567174-2 2018 This sensing strategy involves the reaction of acetylcholine chloride (ACh) with acetylcholinesterase (AChE) to form choline that is in turn catalytically oxidized by choline oxidase (ChOx) to produce hydrogen peroxide (H2O2), thus L-Cys-Ag(I) CP possesses the electro-catalytic property to H2O2 reduction. Choline 53-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 27602288-3 2016 As per the cholinergic hypothesis, the deficiency of choline is responsible for AD; therefore, the inhibition of AChE is a lucrative therapeutic strategy for the treatment of AD. Choline 11-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 27967267-1 2017 INTRODUCTION: Acetylcholinesterase (AChE) is the major enzyme that hydrolyzes acetylcholine, a key neurotransmitter for synaptic transmission, into acetic acid and choline. Choline 20-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 36-40 26921554-0 2016 Choline-induced selective fluorescence quenching of acetylcholinesterase conjugated Au@BSA clusters. Choline 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 26921554-3 2016 The enzyme, AChE hydrolyzes acetylcholine (ACh) to choline (Ch) which in turn interacts with AuQC@BSA-AChE and quenches its fluorescence, enabling sensing. Choline 34-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 12-16 26921554-3 2016 The enzyme, AChE hydrolyzes acetylcholine (ACh) to choline (Ch) which in turn interacts with AuQC@BSA-AChE and quenches its fluorescence, enabling sensing. Choline 34-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 102-106 26813123-4 2016 ACh present at the synaptic cleft is promptly hydrolyzed by the enzyme acetylcholinesterase (AChE), forming acetate and choline, which is recycled into the presynaptic nerve terminal by the high-affinity choline transporter (CHT1). Choline 77-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 27249533-7 2016 The hydrolysis of acetylcholine by acetylcholinesterase into choline was monitored in real-time for a range of acetylcholine concentrations, fused-silica capillary geometries, and operating flow rates. Choline 24-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 35-55 26813123-4 2016 ACh present at the synaptic cleft is promptly hydrolyzed by the enzyme acetylcholinesterase (AChE), forming acetate and choline, which is recycled into the presynaptic nerve terminal by the high-affinity choline transporter (CHT1). Choline 120-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 26813123-4 2016 ACh present at the synaptic cleft is promptly hydrolyzed by the enzyme acetylcholinesterase (AChE), forming acetate and choline, which is recycled into the presynaptic nerve terminal by the high-affinity choline transporter (CHT1). Choline 120-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-97 25038538-2 2014 Based on this phenomenon, acetylcholinesterase (AChE) and choline oxidase (ChOx) are used to catalyze ACh and choline to form the active product H2O2 and the as-produced H2O2 is detected optically. Choline 32-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 25519498-2 2015 Confirmation that the sensor responds to changes in extracellular choline was achieved using local perfusion of choline which resulted in an increase in current, and the acetylcholinesterase inhibitor neostigmine which produced a decrease. Choline 66-73 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-190 25869328-1 2015 Acetylcholinesterase (AChE), the enzyme that rapidly splits acetylcholine into acetate and choline, presents non-cholinergic functions through which may participate in the control of cell proliferation and apoptosis. Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 24973536-3 2014 The blue-to-red color transition of poly(10,12-pentacosadynoic acid) vesicles can be induced by myristoylcholine which is enzymatically hydrolyzed by acetylcholinesterase to myristic acid and choline to prevent the color transition. Choline 105-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-170 24836212-2 2014 The biosensor is based on electrochemical measurement of H2O2 generated from oxidation of choline by immobilized ChO, which in turn is produced from hydrolysis of acetylcholine by immobilized AChE. Choline 90-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 192-196 25132563-2 2014 This strategy involves the reaction of ACh with acetylcholinesterase (AChE) to produce choline, which is further oxidized by choline oxidase (ChOx) to obtain betaine and H2O2. Choline 54-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 24160846-3 2013 This sensing strategy involves the reaction of acetylcholine chloride (ACh) with acetylcholinesterase (AChE) to form choline that is in turn catalytically oxidized by choline oxidase (ChOx) to produce betaine and H2O2 which can quench the photoluminescence (PL) of SiQDs. Choline 53-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 25924313-2 2014 The biological regulator of this neurotransmitter is acetylcholinesterase (AChE), an enzyme that catalyzes the hydrolysis of ACh to choline and acetic acid. Choline 59-66 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 24321698-12 2014 In fact, the complex formed between ChEs and the best N-aryl compound reproduced the binding mode experimentally reported, where the ligand was coupled into the choline-binding site and stabilized through pi-pi interactions with Trp82 or Trp86 for BChE and AChE, respectively, suggesting that this compound could be an efficient inhibitor and supporting our model. Choline 161-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 257-261 24059296-2 2014 AChE is a serine protease, which hydrolyses the neurotransmitter, acetylcholine into acetate and choline thereby terminating neurotransmission. Choline 72-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 24160846-3 2013 This sensing strategy involves the reaction of acetylcholine chloride (ACh) with acetylcholinesterase (AChE) to form choline that is in turn catalytically oxidized by choline oxidase (ChOx) to produce betaine and H2O2 which can quench the photoluminescence (PL) of SiQDs. Choline 53-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 23398232-3 2013 Acetylcholinesterase (AChE) converts ACh to choline, which in turn is oxidized by choline oxidase (ChOx) to produce betaine and H2O2 that generates the reactive oxygen species (ROS). Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 22960624-8 2013 The phosphoramidated-hAChE choline-binding site mutant Y337A showed three-times enhanced reactivation capacity with non-triazole imidazole containing aldoximes (RS113B, RS113A and RS115A) and acetamide derivative (RS194B) than with 2PAM. Choline 27-34 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-26 23408070-14 2013 Moreover, polymorphisms in genes of the cholinergic markers acetylcholinesterase, butyrylcholinesterase, choline acetyltransferase and paraoxonase were found to be associated with better clinical response to acetylcholinesterase inhibitors. Choline 40-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 60-80 23408070-14 2013 Moreover, polymorphisms in genes of the cholinergic markers acetylcholinesterase, butyrylcholinesterase, choline acetyltransferase and paraoxonase were found to be associated with better clinical response to acetylcholinesterase inhibitors. Choline 40-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 208-228 21952774-3 2011 The efficiency of immobilized AChE was monitored by biochemical assay, which was carried out by mixing enzyme-immobilized MC microspheres with model substrate acetylcholine (ACh), and subsequent quantitative determination of substrate ACh and product choline using graphene oxide-based MALDI-TOF-MS with no background inference. Choline 165-172 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-34 21937528-1 2012 Acetylcholinesterase (AChE) is responsible for the rapid hydrolytic degradation of the neurotransmitter acetylcholine into inactive products choline and acetic acid. Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 20641273-3 2004 Acetylcholinesterase (AChE) is the enzyme that terminates cholinergic actions through the rapid hydrolysis of acetylcholine to choline and acetate. Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 27390758-10 2013 This protocol measures the total choline in the cell supernatent under two conditions: 1) After treatment with acetylcholinesterase (AChE), which converts the ACh to choline (also called the total choline sample) and 2) after measuring the amount of free choline in the sample. Choline 33-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 27390758-10 2013 This protocol measures the total choline in the cell supernatent under two conditions: 1) After treatment with acetylcholinesterase (AChE), which converts the ACh to choline (also called the total choline sample) and 2) after measuring the amount of free choline in the sample. Choline 117-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 27390758-10 2013 This protocol measures the total choline in the cell supernatent under two conditions: 1) After treatment with acetylcholinesterase (AChE), which converts the ACh to choline (also called the total choline sample) and 2) after measuring the amount of free choline in the sample. Choline 117-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 27390758-10 2013 This protocol measures the total choline in the cell supernatent under two conditions: 1) After treatment with acetylcholinesterase (AChE), which converts the ACh to choline (also called the total choline sample) and 2) after measuring the amount of free choline in the sample. Choline 117-124 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 20641824-3 2004 Acetylcholinesterase (AChE) is the enzyme that terminates cholinergic actions through the rapid hydrolysis of acetylcholine to choline and acetate. Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 21067438-0 2011 Bifunctional phenolic-choline conjugates as anti-oxidants and acetylcholinesterase inhibitors. Choline 22-29 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-82 21067438-4 2011 Specifically, a series of naturally occurring phenolic acids with recognized anti-oxidant properties (derivatives of caffeic acid, rosmarinic acid, and trolox) have been conjugated with choline to account for the recognition by acetylcholinesterase (AChE). Choline 186-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 228-248 21067438-4 2011 Specifically, a series of naturally occurring phenolic acids with recognized anti-oxidant properties (derivatives of caffeic acid, rosmarinic acid, and trolox) have been conjugated with choline to account for the recognition by acetylcholinesterase (AChE). Choline 186-193 acetylcholinesterase (Cartwright blood group) Homo sapiens 250-254 20178777-1 2010 Acetylcholinesterase (AChE), a highly polymorphic enzyme with various splicing variants and molecular isoforms, plays an essential role in the cholinergic neurotransmission by hydrolyzing acetylcholine into choline and acetate. Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 20945563-3 2004 Acetylcholinesterase (AChE) is the enzyme that terminates cholinergic actions through the rapid hydrolysis of acetylcholine to choline and acetate. Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 20347302-2 2010 The most potent AChEIs disclosed contain an aromatic alkyl-aryl linker between an NSAID and a lipophilic choline mimic and they inhibit acetylcholinesterase (AChE) in the submicromolar range. Choline 105-112 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 19877295-3 2010 Enzymatic hydrolysis of acetylcholine in the synaptic cleft is fast and quickly metabolizes to choline and acetate by acetylcholinesterase. Choline 30-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 20188972-3 2010 The principle of the assay is based on enzymatic hydrolysis of acetylcholine into acetic acid and choline by acetylcholinesterase. Choline 69-76 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-129 20188890-3 2010 The inhibition assay was based on the electrochemical detection of the product of AChE, choline, via a choline oxidase biosensors obtained using prussian-blue modified screen printed electrodes. Choline 88-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 82-86 18007027-0 2007 Use of a "caged" analogue to study the traffic of choline within acetylcholinesterase by kinetic crystallography. Choline 50-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 65-85 18346819-1 2008 Previous experiments demonstrated that second-based transient increases in choline concentrations measured by electrodes coated with choline oxidase (ChOx) and the amperometric detection of hydrogen peroxide validly indicate the depolarization-dependent release of acetylcholine (ACh) and its hydrolysis by endogenous acetylcholinesterase (AChE). Choline 75-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 318-338 18346819-1 2008 Previous experiments demonstrated that second-based transient increases in choline concentrations measured by electrodes coated with choline oxidase (ChOx) and the amperometric detection of hydrogen peroxide validly indicate the depolarization-dependent release of acetylcholine (ACh) and its hydrolysis by endogenous acetylcholinesterase (AChE). Choline 75-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 340-344 15551380-9 2004 These results demonstrated that acetylcholine and choline modulate nitric oxide metabolites on erythrocytes and this effect is mediated by interactions with erythrocyte membrane muscarinic receptors and membrane enzyme acetylcholinesterase. Choline 38-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 219-239 17994573-4 2007 Therefore, benzene-1,4-di-N-substituted carbamates (para compounds), with the angle of 180 degrees between two C(benzene)-O bonds, mimic the preferable anti C-O/C-N conformers of acetylcholine for the choline ethylene backbone in the acetylcholinesterase catalysis. Choline 185-192 acetylcholinesterase (Cartwright blood group) Homo sapiens 234-254 15729675-7 2005 The hydrolysis of acetylcholine (2) by AChE to choline is followed by the [Os(bpy)(2)PyCO(2)H](3+) mediated oxidation of choline to betaine and the concomitant growth of the Au NPs. Choline 24-31 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 15729675-7 2005 The hydrolysis of acetylcholine (2) by AChE to choline is followed by the [Os(bpy)(2)PyCO(2)H](3+) mediated oxidation of choline to betaine and the concomitant growth of the Au NPs. Choline 47-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-43 12105904-1 2002 A combined molecular dynamics simulation and multiple ligand docking approach is applied to study the binding specificity of acetylcholinesterase (AChE) with its natural substrate acetylcholine (ACh), a family of substrate analogues, and choline. Choline 131-138 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-151 12270172-0 2002 Molecular modeling and enzymatic studies of the interaction of a choline analogue and acetylcholinesterase. Choline 65-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 86-106 12270172-3 2002 Enzymatic experiments have also supported the same theoretical conclusion indicating that AChE was able to hydrolyze 1 to choline. Choline 122-129 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 15009674-7 2004 The effect of Abeta1-42 on AChE was blocked by inhibitors of alpha7 nicotinic acetylcholine receptors (alpha7 nAChRs) as well as by inhibitors of L- or N-type voltage-dependent calcium channels (VDCCs), whereas agonists of alpha7 nAChRs (choline, nicotine) increased the level of AChE. Choline 84-91 acetylcholinesterase (Cartwright blood group) Homo sapiens 27-31 12403587-4 2002 The AChE/ChO-modified electrode was then employed as an end-column detector to determine acetylcholine and choline with and without the internal standard butyrylcholine. Choline 95-102 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-8 9301662-0 1997 Synthesis and study of thiocarbonate derivatives of choline as potential inhibitors of acetylcholinesterase. Choline 52-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 87-107 9301662-1 1997 Fourteen alkyl and aryl thiocarbonate derivatives of choline were synthesized and studied as potential inhibitors of acetylcholinesterase (AChE). Choline 53-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 117-137 9301662-1 1997 Fourteen alkyl and aryl thiocarbonate derivatives of choline were synthesized and studied as potential inhibitors of acetylcholinesterase (AChE). Choline 53-60 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 8718877-11 1996 In the latter case, choline was generated enzymatically, within the active site, concomitantly with carbamylation of the acetylcholinesterase. Choline 20-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-141 8899632-11 1996 When AChE was inhibited, three treatments expected to block active choline (Ch) uptake into the presynaptic terminals decreased MEPC size: 1) elevating extracellular K+ to diminish the Na+ electrochemical gradient required for Ch uptake; 2) replacing extracellular Na+ with methylamine+; and 3) adding hemicholinium-3 (HC-3), an inhibitor of the Ch transporter. Choline 67-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 5-9 7661856-0 1995 [Conformational differences in the sorption of choline ligands at the active site of acetylcholinesterase]. Choline 47-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-105 8297012-1 1993 Choline (Ch) and acetylcholine (Ach) microenzyme sensors were developed based on the immobilization of choline oxidase (ChO) and acetylcholinesterase (AchE) at the tip of a 25-micron Pt wire sealed in glass. Choline 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 7965073-6 1994 However, we have made two observations that are surprising in light of our knowledge concerning the vertebrate neuromuscular junction where released ACh is rapidly hydrolyzed by acetylcholinesterase (AChE) to choline, which is then taken up by a high-affinity uptake system. Choline 184-191 acetylcholinesterase (Cartwright blood group) Homo sapiens 200-204 7853361-0 1994 Choline derivatives and sodium fluoride protect acetylcholinesterase against irreversible inhibition and aging by DFP and paraoxon. Choline 0-7 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 8136015-5 1993 AChE was marginally protected from thermal inactivation by the "nonspecific salts" ammonium sulfate and sodium chloride and to a greater extent by the "active site-specific salts" choline chloride, sodium acetate, and acetylcholine iodide. Choline 180-196 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 8297012-1 1993 Choline (Ch) and acetylcholine (Ach) microenzyme sensors were developed based on the immobilization of choline oxidase (ChO) and acetylcholinesterase (AchE) at the tip of a 25-micron Pt wire sealed in glass. Choline 0-2 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 2310017-2 1990 Acetylcholine and choline eluting from the LC column are introduced into a reactor containing immobilized acetylcholinesterase, which hydrolyzes acetylcholine to choline. Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 2146369-2 1990 Because of these findings, the cholinergic function in HD was studied by measuring cerebrospinal fluid (CSF) choline levels and AChE activity during a randomized, double-blind, cross-over, placebo-controlled clinical trial of isoniazid. Choline 31-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 128-132 1497415-1 1992 Acetylcholinesterase (AChe) hydrolyses acetylcholine to choline and acetate, thereby inactivating the neurotransmitter. Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-26 1504265-7 1992 The conformation of AChE-bound choline must be gauche to support our suggestion that hemicholiniums are conformationally constrained analogues of choline. Choline 31-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 1504265-7 1992 The conformation of AChE-bound choline must be gauche to support our suggestion that hemicholiniums are conformationally constrained analogues of choline. Choline 146-153 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 1504265-12 1992 18, 292-300] that the active site of AChE has ample space for rotation about the C-C bond in choline. Choline 93-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 37-41 1777989-3 1991 Acetylcholine or butyrylcholine, in the presence of samples containing acetylcholinesterase or butyrylcholinesterase are specifically hydrolyzed, the formation of choline being detected vs time by the sensor with no need for a selective inhibitor. Choline 6-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 2310017-2 1990 Acetylcholine and choline eluting from the LC column are introduced into a reactor containing immobilized acetylcholinesterase, which hydrolyzes acetylcholine to choline. Choline 18-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126