PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28069796-14	2017	MTHFR protein and mRNA were reduced in embryonic liver, with lower concentrations of choline, betaine and phosphocholine.	Choline	85-92	methylenetetrahydrofolate reductase	Mus musculus	0-5	
32948746-0	2020	The influence of choline treatment on behavioral and neurochemical autistic-like phenotype in Mthfr-deficient mice.	Choline	17-24	methylenetetrahydrofolate reductase	Mus musculus	94-99	
32948746-5	2020	Here we tested the potential of choline supplementation to Mthfr-deficient mice at young-adulthood to reduce behavioral and neurochemical changes reminiscent of autism characteristics.	Choline	32-39	methylenetetrahydrofolate reductase	Mus musculus	59-64	
32948746-7	2020	Choline supplementation to adult offspring of Mthfr+/- mothers for 14 days counteracted characteristics related to repetitive behavior and anxiety both in males and in females and improved social behavior solely in male mice.	Choline	0-7	methylenetetrahydrofolate reductase	Mus musculus	46-51	
32948746-9	2020	The results demonstrate that choline supplementation even at adulthood, not tested previously, to offspring of Mthfr-deficient mothers, attenuates the autistic-like phenotype.	Choline	29-36	methylenetetrahydrofolate reductase	Mus musculus	111-116	
32521649-10	2020	Reduced MTHFR protein in the livers of FASD mothers and male pups resulted in choline/methyl metabolite disruptions in offspring liver (decreased betaine) and brain (decreased glycerophosphocholine and sphingomyelin in male pups, and decreased phosphatidylcholine in both sexes).	Choline	78-85	methylenetetrahydrofolate reductase	Mus musculus	8-13	
30288696-6	2019	We observed short-term memory impairment measured by the novel object paradigm, altered transcriptional levels of synaptic markers and epigenetic enzymes, as well as impaired choline metabolism due to the Mthfr+/- genotype in cortex or hippocampus.	Choline	175-182	methylenetetrahydrofolate reductase	Mus musculus	205-210	
25956258-2	2015	In earlier work, we showed that mice with a complete deficiency of methylenetetrahydrofolate reductase (MTHFR), a critical enzyme in folate and homocysteine metabolism, had cognitive impairment with disturbances in choline metabolism.	Choline	215-222	methylenetetrahydrofolate reductase	Mus musculus	104-109	
22259189-1	2012	Low dietary choline or deficiency of methylenetetrahydrofolate reductase (Mthfr) leads to hyperhomocysteinemia (Hhcy) and adverse reproductive outcomes.	Choline	12-19	methylenetetrahydrofolate reductase	Mus musculus	74-79	
15217352-9	2004	The dramatic effects of betaine on survival and growth, and the partial reversibility of the biochemical and developmental anomalies in the brains of MTHFR-deficient mice, emphasize an important role for choline and betaine depletion in the pathogenesis of homocystinuria due to MTHFR deficiency.	Choline	204-211	methylenetetrahydrofolate reductase	Mus musculus	150-155	
21697299-5	2011	Mthfr heterozygosity did not alter brain choline metabolite concentrations, but it did enhance their labeling in males (P < 0.05) and tended to do so in females (P < 0.10), a finding consistent with greater turnover of dietary choline in brains of +/- mice.	Choline	233-240	methylenetetrahydrofolate reductase	Mus musculus	0-5	
21697299-0	2011	Folate intake, MTHFR genotype, and sex modulate choline metabolism in mice.	Choline	48-55	methylenetetrahydrofolate reductase	Mus musculus	15-20	
21697299-3	2011	This study investigated the hypothesis that reductions in methyl group supply, either due to dietary folate deficiency or Mthfr gene deletion, would modify tissue choline metabolism in a sex-specific manner.	Choline	163-170	methylenetetrahydrofolate reductase	Mus musculus	122-127	
15217352-9	2004	The dramatic effects of betaine on survival and growth, and the partial reversibility of the biochemical and developmental anomalies in the brains of MTHFR-deficient mice, emphasize an important role for choline and betaine depletion in the pathogenesis of homocystinuria due to MTHFR deficiency.	Choline	204-211	methylenetetrahydrofolate reductase	Mus musculus	279-284	
12551843-4	2003	We administered the alternate choline-derived methyl donor, betaine, to wild-type mice and to littermates with mild or severe hyperhomocysteinemia due to hetero- or homozygosity for a disruption of the Mthfr gene.	Choline	30-37	methylenetetrahydrofolate reductase	Mus musculus	202-207	
12551843-5	2003	On control diets, plasma homocysteine and liver choline metabolite levels were strongly dependent on the Mthfr genotype.	Choline	48-55	methylenetetrahydrofolate reductase	Mus musculus	105-110	
12551843-10	2003	Hyperhomocysteinemic Mthfr-compromised mice appear to be much more sensitive to changes of choline/betaine intake than do wild-type animals.	Choline	91-98	methylenetetrahydrofolate reductase	Mus musculus	21-26	
12551843-11	2003	Hyperhomocysteinemia, in the range of that associated with folate deficiency or with homozygosity for the 677T MTHFR variant, may be associated with disturbed choline metabolism.	Choline	159-166	methylenetetrahydrofolate reductase	Mus musculus	111-116