PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18088187-9	2007	The pathway of Chk1 phosphorylation --> Cdc25A degradation --> inhibition of cyclin B1/Cdk1 activity --> G2 arrest is accordingly resistant to staurosporine and UCN-01 in p53+/+ cells.	7-hydroxystaurosporine	170-176	cyclin dependent kinase 1	Homo sapiens	93-97	
19223503-8	2009	The combination of rapamycin and UCN-01 synergistically inhibited the DLBCL cell proliferation by inducing G1 arrest as well as apoptosis by suppressing the phosphorylation of p70S6K/p85S6K and CDC2 expression.	7-hydroxystaurosporine	33-39	cyclin dependent kinase 1	Homo sapiens	194-198	
15169628-6	2004	Measurements of cyclin A and B protein levels, Cdk2 and Cdc2 kinase activities, Cdc25C phosphorylation, and Chk1 kinase activity were consistent with UCN-01-induced abrogation of the S/G2-phase checkpoint in ara-C treated cells.	7-hydroxystaurosporine	150-156	cyclin dependent kinase 1	Homo sapiens	56-60	
11278490-8	2001	Caffeine or UCN-01 abolishes the extreme radioresistance with the strong G(2) arrest and at the same time reduces the phosphorylation of Cdc2 in A1-5 cells.	7-hydroxystaurosporine	12-18	cyclin dependent kinase 1	Homo sapiens	137-141	
15200121-4	2004	The p38 inhibitor SB203580 or the Chk1 inhibitor UCN-01 or their combination blocked TMZ-mediated inactivation of cdc25C and cdc2, suggesting that p38 and Chk1 pathways work cooperatively and are both necessary to inactivate cdc25C and cdc2.	7-hydroxystaurosporine	49-52	cyclin dependent kinase 1	Homo sapiens	114-118	
15200121-4	2004	The p38 inhibitor SB203580 or the Chk1 inhibitor UCN-01 or their combination blocked TMZ-mediated inactivation of cdc25C and cdc2, suggesting that p38 and Chk1 pathways work cooperatively and are both necessary to inactivate cdc25C and cdc2.	7-hydroxystaurosporine	49-52	cyclin dependent kinase 1	Homo sapiens	125-129	
12118331-5	2002	Despite failing to enhance apoptosis, UCN-01 treatment abrogated IR-induced G2/M arrest in both cell lines, an event associated with enhanced activation of cyclin-dependent kinase 1 (cdk1), promotion of G0/G1 arrest, and dephosphorylation of the retinoblastoma protein (pRb).	7-hydroxystaurosporine	38-44	cyclin dependent kinase 1	Homo sapiens	156-181	
12118331-5	2002	Despite failing to enhance apoptosis, UCN-01 treatment abrogated IR-induced G2/M arrest in both cell lines, an event associated with enhanced activation of cyclin-dependent kinase 1 (cdk1), promotion of G0/G1 arrest, and dephosphorylation of the retinoblastoma protein (pRb).	7-hydroxystaurosporine	38-44	cyclin dependent kinase 1	Homo sapiens	183-187	
11895447-6	2002	This lack of effect was not due to cytotoxicity, as cells exposed to ergosterol remained viable and, upon supplementing with UCN-01, an activator of Cdk1, they progressed through mitosis.	7-hydroxystaurosporine	125-131	cyclin dependent kinase 1	Homo sapiens	149-153	
7574801-7	1995	UCN-01, a protein kinase-C inhibitor, also inhibits both cdc2 and CDK2 kinase.	7-hydroxystaurosporine	0-6	cyclin dependent kinase 1	Homo sapiens	57-61	
8547221-0	1995	Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2.	7-hydroxystaurosporine	13-35	cyclin dependent kinase 1	Homo sapiens	89-121