PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30834235-9 2019 Furthermore, co-treatment with IO and UCN-01 significantly increased cell death in primary cells expressing mutant p53. 7-hydroxystaurosporine 38-44 tumor protein p53 Homo sapiens 115-118 21889927-6 2011 An M2 induced DDR in p53-defective MDA-MB-231 cells was abrogated by UCN-01, a ubiquitous inhibitor of kinases including Chk1, in a response associated with substantial mitotic catastrophe and strong synergy. 7-hydroxystaurosporine 69-75 tumor protein p53 Homo sapiens 21-24 23537372-11 2013 CONCLUSIONS: These findings suggest that UCN-01 induces hepatoma cell growth inhibition by regulating the p53/p21(waf1) and CHK2/CDC25 pathways. 7-hydroxystaurosporine 41-47 tumor protein p53 Homo sapiens 106-109 22905155-2 2012 This arrest can be abrogated in p53-defective cells by the Chk1 inhibitor 7-hydroxystaurosporine (UCN-01). 7-hydroxystaurosporine 74-96 tumor protein p53 Homo sapiens 32-35 22905155-2 2012 This arrest can be abrogated in p53-defective cells by the Chk1 inhibitor 7-hydroxystaurosporine (UCN-01). 7-hydroxystaurosporine 98-104 tumor protein p53 Homo sapiens 32-35 22101337-7 2011 We also show that the checkpoint kinase inhibitor UCN-01 abolishes the G2 arrest induced by the veliparib and topotecan combination and further increases cell death in both p53-wildtype and -mutant cells. 7-hydroxystaurosporine 50-56 tumor protein p53 Homo sapiens 173-176 18088187-9 2007 The pathway of Chk1 phosphorylation --> Cdc25A degradation --> inhibition of cyclin B1/Cdk1 activity --> G2 arrest is accordingly resistant to staurosporine and UCN-01 in p53+/+ cells. 7-hydroxystaurosporine 170-176 tumor protein p53 Homo sapiens 180-183 18642443-1 2008 We have previously shown that tetraploid cancer cells succumb through a p53-dependent apoptotic pathway when checkpoint kinase 1 (Chk1) is depleted by small interfering RNAs (siRNAs) or inhibited with 7-hydroxystaurosporine (UCN-01). 7-hydroxystaurosporine 201-223 tumor protein p53 Homo sapiens 72-75 17900801-5 2007 Combining the Chk1 inhibitor UCN-01 dramatically enhanced the response to AG490 in p53-mutated or deleted glioma cells. 7-hydroxystaurosporine 29-35 tumor protein p53 Homo sapiens 83-86 15642191-2 2005 This study was to observe the abrogation of radiation-induced G(2) phase arrest of p53 mutated human cancer cell lines by 7-hydroxystaurosporine (UCN-01), and explore the mechanism. 7-hydroxystaurosporine 122-144 tumor protein p53 Homo sapiens 83-86 15782134-2 2005 The Chk1 inhibitor, 7-hydroxystaurosporine (UCN-01), overcomes both S and G(2) arrest preferentially in cells mutated for p53, driving cells through a lethal mitosis and thereby enhancing cytotoxicity. 7-hydroxystaurosporine 20-42 tumor protein p53 Homo sapiens 122-125 15466201-5 2004 Sensitization to IR-induced apoptosis by caffeine or UCN-01 was abrogated neither by cycloheximide nor by pifithrin-alpha, an inhibitor of the transcriptional activity of p53. 7-hydroxystaurosporine 53-59 tumor protein p53 Homo sapiens 171-174 14743382-6 2004 When their DNA is damaged, p53-defective tumor cells preferentially arrest in S or G2 phase where they are susceptible to checkpoint inhibitors such as caffeine and UCN-01. 7-hydroxystaurosporine 165-171 tumor protein p53 Homo sapiens 27-30 15724841-1 2004 We previously reported (Cancer Chemother Pharmacol 45: 252-258, 2000) that UCN-01 (7-hydroxystaurosporine), a protein kinase inhibitor, which is under clinical trials as an anti-cancer agent in the USA and Japan, enhanced camptothecin-induced cytotoxicity in breast cancer cells that lack p53 function. 7-hydroxystaurosporine 75-81 tumor protein p53 Homo sapiens 289-292 15724841-1 2004 We previously reported (Cancer Chemother Pharmacol 45: 252-258, 2000) that UCN-01 (7-hydroxystaurosporine), a protein kinase inhibitor, which is under clinical trials as an anti-cancer agent in the USA and Japan, enhanced camptothecin-induced cytotoxicity in breast cancer cells that lack p53 function. 7-hydroxystaurosporine 83-105 tumor protein p53 Homo sapiens 289-292 15724841-9 2004 Detailed cell-cycle analyses revealed that UCN-01 abrogated S-phase accumulation induced by topotecan treatment in p53 defective MDA231 tumor cells and HMEC/E6 cells. 7-hydroxystaurosporine 43-49 tumor protein p53 Homo sapiens 115-118 15724841-12 2004 These data indicate that UCN-01 selectively enhances topotecan cytotoxicity in p53 defective cells through the induction of apoptotic signaling pathway(s), although the time course for the induction of cell death is not the same. 7-hydroxystaurosporine 25-31 tumor protein p53 Homo sapiens 79-82 12517773-2 2003 We have reported that UCN-01 (7-hydroxystaurosporine) abrogates DNA damage-induced S and G(2) arrest and enhances cytotoxicity selectively in p53 mutant cells, thus providing a potential, tumor-targeted therapy. 7-hydroxystaurosporine 22-28 tumor protein p53 Homo sapiens 142-145 12517773-2 2003 We have reported that UCN-01 (7-hydroxystaurosporine) abrogates DNA damage-induced S and G(2) arrest and enhances cytotoxicity selectively in p53 mutant cells, thus providing a potential, tumor-targeted therapy. 7-hydroxystaurosporine 30-52 tumor protein p53 Homo sapiens 142-145 9395460-1 1997 We previously demonstrated that the anticancer agent and protein kinase C (PKC) inhibitor 7-hydroxystaurosporine (UCN-01) induces apoptosis independently of p53 and protein synthesis in HL60 cells. 7-hydroxystaurosporine 90-112 tumor protein p53 Homo sapiens 157-160 11953432-6 2002 In the p53 mutant cells, low concentrations of UCN-01 caused S phase cells to progress to G(2) before undergoing mitosis and death, whereas high concentrations caused rapid premature mitosis and death of S phase cells. 7-hydroxystaurosporine 47-53 tumor protein p53 Homo sapiens 7-10 12071807-0 2002 7-Hydroxystaurosporine (UCN-01) preferentially sensitizes cells with a disrupted TP53 to gamma radiation in lung cancer cell lines. 7-hydroxystaurosporine 0-22 tumor protein p53 Homo sapiens 81-85 11029511-1 2000 Previous research has shown synergistic growth inhibition between UCN-01 and camptothecin (CPT) in tumor cells with mutant p53 versus tumor cells with wild-type p53. 7-hydroxystaurosporine 66-72 tumor protein p53 Homo sapiens 123-126 10699952-2 2000 Subsequent studies from other laboratories revealed that UCN-01 could selectively enhance cytotoxicity of DNA damaging agents in p53 defective cells and that this was mediated by abrogation of S and /or G(2) arrest by UCN-01. 7-hydroxystaurosporine 57-63 tumor protein p53 Homo sapiens 129-132 10699952-2 2000 Subsequent studies from other laboratories revealed that UCN-01 could selectively enhance cytotoxicity of DNA damaging agents in p53 defective cells and that this was mediated by abrogation of S and /or G(2) arrest by UCN-01. 7-hydroxystaurosporine 57-60 tumor protein p53 Homo sapiens 129-132 10699952-3 2000 In this study, we report that UCN-01 selectively enhances the cytotoxicity of MMC in human p53 mutant cell lines. 7-hydroxystaurosporine 30-36 tumor protein p53 Homo sapiens 91-94 10699952-7 2000 Detailed cell-cycle studies revealed that UCN-01 abrogated S and G(2) phase accumulation induced by MMC in p53 defective cells and to a lesser extent in p53 wild-type cell lines. 7-hydroxystaurosporine 42-48 tumor protein p53 Homo sapiens 107-110 10663644-1 2000 PURPOSE: To determine the ability of UCN-01 to abrogate the cell cycle arrest induced by camptothecin (CPT) in tumor cells that lack p53 function, and therefore enhance the cytotoxicity of CPT in these cells in relation to normal cells with wild-type p53. 7-hydroxystaurosporine 37-43 tumor protein p53 Homo sapiens 251-254 10663644-14 2000 Our findings suggest potential usefulness of combining UCN-01 in topoisomerase I inhibitor-based drug therapy for the treatment of breast cancer with a dysfunctional p53 gene. 7-hydroxystaurosporine 55-61 tumor protein p53 Homo sapiens 166-169 9395460-1 1997 We previously demonstrated that the anticancer agent and protein kinase C (PKC) inhibitor 7-hydroxystaurosporine (UCN-01) induces apoptosis independently of p53 and protein synthesis in HL60 cells. 7-hydroxystaurosporine 114-120 tumor protein p53 Homo sapiens 157-160 9815601-11 1997 p53 wild-type cells seem to be more sensitive to the cytotoxic effects of the combination of UCN-01 + CDDP than the p53 mutant cells. 7-hydroxystaurosporine 93-99 tumor protein p53 Homo sapiens 0-3 9307289-0 1997 Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function. 7-hydroxystaurosporine 85-107 tumor protein p53 Homo sapiens 168-171