PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21356152-1 2011 The eicosanoids 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs), which are generated from the metabolism of arachidonic acid by cytochrome P450 (CYP) enzymes, possess a wide array of biological actions, including the regulation of blood flow to organs. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 16-47 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 159-174 21356152-1 2011 The eicosanoids 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs), which are generated from the metabolism of arachidonic acid by cytochrome P450 (CYP) enzymes, possess a wide array of biological actions, including the regulation of blood flow to organs. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 16-47 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 176-179 21356152-1 2011 The eicosanoids 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs), which are generated from the metabolism of arachidonic acid by cytochrome P450 (CYP) enzymes, possess a wide array of biological actions, including the regulation of blood flow to organs. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 49-56 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 159-174 21356152-1 2011 The eicosanoids 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs), which are generated from the metabolism of arachidonic acid by cytochrome P450 (CYP) enzymes, possess a wide array of biological actions, including the regulation of blood flow to organs. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 49-56 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 176-179 20869469-1 2011 Cytochrome P450 (CYP)-dependent metabolites of arachidonic acid (AA), such as epoxyeicosatrienoic acids and 20-hydroxyeicosatetraenoic acid, serve as second messengers of various hormones and growth factors and play pivotal roles in the regulation of vascular, renal and cardiac function. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 108-139 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 20869469-1 2011 Cytochrome P450 (CYP)-dependent metabolites of arachidonic acid (AA), such as epoxyeicosatrienoic acids and 20-hydroxyeicosatetraenoic acid, serve as second messengers of various hormones and growth factors and play pivotal roles in the regulation of vascular, renal and cardiac function. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 108-139 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 17-20 15262846-1 2004 BACKGROUND: 20-hydroxyeicosatetraenoic acid (20-HETE) is a cytochrome P450 (omega-hydroxylase) metabolite of arachidonic acid with vasoconstrictor activity that may be involved in the pathogenesis of hypertension. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 12-43 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 59-93 19615687-1 2009 BACKGROUND: Cytochrome P450 (CYP) is expressed in the human endothelium and metabolizes arachidonic acid into vasoactive epoxyeicosatrienoic and 20-hydroxyeicosatetraenoic acids. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 145-177 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 12-27 19615687-1 2009 BACKGROUND: Cytochrome P450 (CYP) is expressed in the human endothelium and metabolizes arachidonic acid into vasoactive epoxyeicosatrienoic and 20-hydroxyeicosatetraenoic acids. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 145-177 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 29-32 17164129-4 2007 A number of these enzymes, including members of the CYP 4 family, predominantly catalyze conversion of AA to 20-hydroxyeicosatetraenoic acid (20-HETE) while the CYP epoxygenases generate mainly epoxyeicosatrienoic acids (EETs). 20-hydroxy-5,8,11,14-eicosatetraenoic acid 109-140 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 52-55 17164129-4 2007 A number of these enzymes, including members of the CYP 4 family, predominantly catalyze conversion of AA to 20-hydroxyeicosatetraenoic acid (20-HETE) while the CYP epoxygenases generate mainly epoxyeicosatrienoic acids (EETs). 20-hydroxy-5,8,11,14-eicosatetraenoic acid 142-149 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 52-55 17164129-4 2007 A number of these enzymes, including members of the CYP 4 family, predominantly catalyze conversion of AA to 20-hydroxyeicosatetraenoic acid (20-HETE) while the CYP epoxygenases generate mainly epoxyeicosatrienoic acids (EETs). 20-hydroxy-5,8,11,14-eicosatetraenoic acid 142-149 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 161-164 17164132-6 2007 For example, CYP mediated hydroxylation of AA produces 20-hydroxyeicosatetraenoic acid (20-HETE) which has detrimental effects in the heart during ischemia, pro-inflammatory effects during reperfusion and potent vasoconstrictor effects in the coronary circulation. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 55-86 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 13-16 17164132-6 2007 For example, CYP mediated hydroxylation of AA produces 20-hydroxyeicosatetraenoic acid (20-HETE) which has detrimental effects in the heart during ischemia, pro-inflammatory effects during reperfusion and potent vasoconstrictor effects in the coronary circulation. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 88-95 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 13-16 16251477-3 2006 We previously found that mechanical strain generated by subjecting lymphocytes to hypotonic challenge triggered AA production and that two CYP450 products of AA, 5,6-epoxyeicosatrienoic acid (5,6-EET) and 20-hydroxyeicosatetraenoic acid (20-HETE), as well as a product of LOX, 5-(S)-hydroperoxyeicosatetrenoic acid (5-HPETE), induced Ca(2+) entry into primary B cells. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 205-236 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 139-145 16251477-3 2006 We previously found that mechanical strain generated by subjecting lymphocytes to hypotonic challenge triggered AA production and that two CYP450 products of AA, 5,6-epoxyeicosatrienoic acid (5,6-EET) and 20-hydroxyeicosatetraenoic acid (20-HETE), as well as a product of LOX, 5-(S)-hydroperoxyeicosatetrenoic acid (5-HPETE), induced Ca(2+) entry into primary B cells. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 238-245 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 139-145 15993870-4 2005 Several lines of data support the possibility that certain CYP metabolites resulting from the hydroxylation of AA such as 20-hydroxyeicosatetraenoic acid (20-HETE) are potent vasoconstrictors and may produce detrimental effects in the heart during ischemia and pro-inflammatory effects during reperfusion. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 122-153 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 59-62 15993870-4 2005 Several lines of data support the possibility that certain CYP metabolites resulting from the hydroxylation of AA such as 20-hydroxyeicosatetraenoic acid (20-HETE) are potent vasoconstrictors and may produce detrimental effects in the heart during ischemia and pro-inflammatory effects during reperfusion. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 155-162 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 59-62 15503650-4 2004 Cytochrome P450 metabolism of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE) or epoxyeicosatrienoic acids (EETs) provides a mechanism for the constriction and relaxation of cerebral arteries, respectively. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 50-81 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 15503650-4 2004 Cytochrome P450 metabolism of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE) or epoxyeicosatrienoic acids (EETs) provides a mechanism for the constriction and relaxation of cerebral arteries, respectively. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 83-90 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 15630035-0 2005 Cytochrome P-450 under pressure: more evidence for a link between 20-hydroxyeicosatetraenoic acid and hypertension. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 66-97 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-16 15262846-1 2004 BACKGROUND: 20-hydroxyeicosatetraenoic acid (20-HETE) is a cytochrome P450 (omega-hydroxylase) metabolite of arachidonic acid with vasoconstrictor activity that may be involved in the pathogenesis of hypertension. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 45-52 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 59-93 15202615-4 2004 RECENT FINDINGS: Studies have demonstrated that the expression of cytochrome P-450 enzymes and the synthesis of 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids in the kidney and peripheral vasculature are altered in many genetic and experimental models of hypertension. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 112-143 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 66-82 11195057-1 2001 Recent studies indicate that arachidonic acid is primarily metabolized by cytochrome P450 enzymes of the 4A and 2C families in the kidney to 20-hydroxyeicosatetraenoic acid (HETE), epoxyeicosatrienoic acids (EETs) and dihydroxyeicosatrienoic acids. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 141-172 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 74-89 14626496-2 2003 CYP-AA metabolites, 19- and 20-hydroxyeicosatetraenoic acids (HETEs), epoxyeicosatrienoic acids (EETs) and diHETEs have different biological properties based on sites of production and can be stored in tissue lipids and released in response to hormonal stimuli. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 62-67 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-3 12570747-1 2003 Arachidonic acid can be metabolized by cytochrome p450 (CYP450) enzymes to 5,6-, 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acids (EETs), their corresponding dihydroxyeicosa-trienoic acids (DHETs), and 20-hydroxyeicosatetraenoic acid (20-HETE). 20-hydroxy-5,8,11,14-eicosatetraenoic acid 203-234 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 39-54 12570747-1 2003 Arachidonic acid can be metabolized by cytochrome p450 (CYP450) enzymes to 5,6-, 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acids (EETs), their corresponding dihydroxyeicosa-trienoic acids (DHETs), and 20-hydroxyeicosatetraenoic acid (20-HETE). 20-hydroxy-5,8,11,14-eicosatetraenoic acid 203-234 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 56-62 12570747-1 2003 Arachidonic acid can be metabolized by cytochrome p450 (CYP450) enzymes to 5,6-, 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acids (EETs), their corresponding dihydroxyeicosa-trienoic acids (DHETs), and 20-hydroxyeicosatetraenoic acid (20-HETE). 20-hydroxy-5,8,11,14-eicosatetraenoic acid 236-243 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 39-54 12570747-1 2003 Arachidonic acid can be metabolized by cytochrome p450 (CYP450) enzymes to 5,6-, 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acids (EETs), their corresponding dihydroxyeicosa-trienoic acids (DHETs), and 20-hydroxyeicosatetraenoic acid (20-HETE). 20-hydroxy-5,8,11,14-eicosatetraenoic acid 236-243 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 56-62 11668070-1 2001 This study was conducted to test the hypothesis that the cytochrome P-450 (CYP450) metabolite 20-hydroxyeicosatetraenoic acid (20-HETE) contributes to the afferent arteriolar response to P2 receptor activation. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 94-125 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 57-73 11668070-1 2001 This study was conducted to test the hypothesis that the cytochrome P-450 (CYP450) metabolite 20-hydroxyeicosatetraenoic acid (20-HETE) contributes to the afferent arteriolar response to P2 receptor activation. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 94-125 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 75-81 11668070-1 2001 This study was conducted to test the hypothesis that the cytochrome P-450 (CYP450) metabolite 20-hydroxyeicosatetraenoic acid (20-HETE) contributes to the afferent arteriolar response to P2 receptor activation. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 127-134 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 57-73 11668070-1 2001 This study was conducted to test the hypothesis that the cytochrome P-450 (CYP450) metabolite 20-hydroxyeicosatetraenoic acid (20-HETE) contributes to the afferent arteriolar response to P2 receptor activation. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 127-134 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 75-81 11668070-9 2001 Taken together, these results are consistent with the hypothesis that the CYP450 metabolite 20-HETE participates in the afferent arteriolar response to activation of P2X receptors. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 92-99 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 74-80 11679404-5 2001 This review summarizes the vascular effects of epoxyeicosatrienoic acids and 20-hydroxyeicosatetraenoic acid, both of which are CYP-derived metabolites of arachidonic acid, endogenously generated within endothelial and vascular smooth muscle cells. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 77-108 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 128-131 11773611-1 2002 Recent studies have indicated that arachidonic acid is primarily metabolized by cytochrome P-450 (CYP) enzymes in the brain, lung, kidney, and peripheral vasculature to 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) and that these compounds play critical roles in the regulation of renal, pulmonary, and cardiac function and vascular tone. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 169-200 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 80-96 11773611-1 2002 Recent studies have indicated that arachidonic acid is primarily metabolized by cytochrome P-450 (CYP) enzymes in the brain, lung, kidney, and peripheral vasculature to 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) and that these compounds play critical roles in the regulation of renal, pulmonary, and cardiac function and vascular tone. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 169-200 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 98-101 11773611-1 2002 Recent studies have indicated that arachidonic acid is primarily metabolized by cytochrome P-450 (CYP) enzymes in the brain, lung, kidney, and peripheral vasculature to 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) and that these compounds play critical roles in the regulation of renal, pulmonary, and cardiac function and vascular tone. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 202-209 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 80-96 11773611-1 2002 Recent studies have indicated that arachidonic acid is primarily metabolized by cytochrome P-450 (CYP) enzymes in the brain, lung, kidney, and peripheral vasculature to 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) and that these compounds play critical roles in the regulation of renal, pulmonary, and cardiac function and vascular tone. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 202-209 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 98-101 11195057-1 2001 Recent studies indicate that arachidonic acid is primarily metabolized by cytochrome P450 enzymes of the 4A and 2C families in the kidney to 20-hydroxyeicosatetraenoic acid (HETE), epoxyeicosatrienoic acids (EETs) and dihydroxyeicosatrienoic acids. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 174-178 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 74-89 9651188-1 1998 We previously reported that 20-hydroxyeicosatetraenoic acid (20-HETE) is an endogenous cytochrome P450 (cP450) 4A metabolite of arachidonic acid (AA) in human lung tissue, and is a potent cyclooxygenase-dependent vasodilator of isolated pulmonary arteries. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 28-59 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 87-102 9651188-1 1998 We previously reported that 20-hydroxyeicosatetraenoic acid (20-HETE) is an endogenous cytochrome P450 (cP450) 4A metabolite of arachidonic acid (AA) in human lung tissue, and is a potent cyclooxygenase-dependent vasodilator of isolated pulmonary arteries. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 28-59 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 104-109 9651188-1 1998 We previously reported that 20-hydroxyeicosatetraenoic acid (20-HETE) is an endogenous cytochrome P450 (cP450) 4A metabolite of arachidonic acid (AA) in human lung tissue, and is a potent cyclooxygenase-dependent vasodilator of isolated pulmonary arteries. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 61-68 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 87-102 9651188-1 1998 We previously reported that 20-hydroxyeicosatetraenoic acid (20-HETE) is an endogenous cytochrome P450 (cP450) 4A metabolite of arachidonic acid (AA) in human lung tissue, and is a potent cyclooxygenase-dependent vasodilator of isolated pulmonary arteries. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 61-68 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 104-109 30400671-2 2018 Arachidonic acid (AA) is metabolized by cytochrome P450 (CYP450) enzymes to epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), vasoactive and natriuretic metabolites that contribute to blood pressure (BP) regulation. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 113-144 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 40-55 9176244-1 1997 We investigated the effect of 20-hydroxyeicosatetraenoic acid (20-HETE), an arachidonic acid metabolite of the cytochrome P-450 (cP450) 4A pathway, on human pulmonary arterial tone. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 30-61 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 111-127 9176244-1 1997 We investigated the effect of 20-hydroxyeicosatetraenoic acid (20-HETE), an arachidonic acid metabolite of the cytochrome P-450 (cP450) 4A pathway, on human pulmonary arterial tone. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 30-61 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 129-134 9176244-1 1997 We investigated the effect of 20-hydroxyeicosatetraenoic acid (20-HETE), an arachidonic acid metabolite of the cytochrome P-450 (cP450) 4A pathway, on human pulmonary arterial tone. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 63-70 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 111-127 9176244-1 1997 We investigated the effect of 20-hydroxyeicosatetraenoic acid (20-HETE), an arachidonic acid metabolite of the cytochrome P-450 (cP450) 4A pathway, on human pulmonary arterial tone. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 63-70 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 129-134 1327375-2 1992 The cytochrome P-450 metabolite of arachidonic acid, 20-hydroxyeicosatetraenoic acid (20-HETE), was found to be a potent, dose-dependent inhibitor of platelet aggregation and inhibitor of thromboxane biosynthesis induced by arachidonic acid (IC50 5.2 +/- 1.5 microM), A23187 (IC50 16.2 +/- 5.4 microM), and U46619 (IC50 7.8 +/- 2.4 microM). 20-hydroxy-5,8,11,14-eicosatetraenoic acid 53-84 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 4-20 1327375-2 1992 The cytochrome P-450 metabolite of arachidonic acid, 20-hydroxyeicosatetraenoic acid (20-HETE), was found to be a potent, dose-dependent inhibitor of platelet aggregation and inhibitor of thromboxane biosynthesis induced by arachidonic acid (IC50 5.2 +/- 1.5 microM), A23187 (IC50 16.2 +/- 5.4 microM), and U46619 (IC50 7.8 +/- 2.4 microM). 20-hydroxy-5,8,11,14-eicosatetraenoic acid 86-93 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 4-20 33095237-7 2020 CYP enzymes produce two types of eicosanoid products: EDHF vasodilator epoxyeicosatrienoic acids (EETs) and the vasoconstrictor 20-HETE. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 128-135 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-3 1412450-1 1992 Cytochrome P450 represents the third metabolic pathway of arachidonic acid giving rise to several biologically active compounds, such as 19-HETE, 20-HETE and EETs and their corresponding DHETs. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 146-153 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 30048707-1 2018 20-HETE, the omega-hydroxylation product of arachidonic acid catalyzed by enzymes of the cytochrome P450 (CYP) 4A and 4F gene families, is a bioactive lipid mediator with potent effects on the vasculature including stimulation of smooth muscle cell contractility, migration and proliferation as well as activation of endothelial cell dysfunction and inflammation. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 0-7 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 89-120 30259074-3 2018 Therefore, this study was designed to develop CYP4F selective inhibitors using a novel inhibitory assay of 20-HETE formation. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 107-114 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 46-51 30400671-2 2018 Arachidonic acid (AA) is metabolized by cytochrome P450 (CYP450) enzymes to epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), vasoactive and natriuretic metabolites that contribute to blood pressure (BP) regulation. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 113-144 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 57-63 30400671-2 2018 Arachidonic acid (AA) is metabolized by cytochrome P450 (CYP450) enzymes to epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), vasoactive and natriuretic metabolites that contribute to blood pressure (BP) regulation. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 146-153 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 40-55 30400671-2 2018 Arachidonic acid (AA) is metabolized by cytochrome P450 (CYP450) enzymes to epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), vasoactive and natriuretic metabolites that contribute to blood pressure (BP) regulation. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 146-153 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 57-63 27087514-1 2016 AIM: To better understand the relationship between the interactions among rs17110453, rs751141, and rs9333025 variants and plasma levels of cytochrome P450 (CYP) metabolites, i.e.,20-hydroxyeicosatetraenoic acid (20-HETE), epoxyeicosatrienoic acids (EETs), and dihydroxyeicosatrienoic acids (DiHETEs) in ischemia stroke (IS). 20-hydroxy-5,8,11,14-eicosatetraenoic acid 180-211 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 140-155 28767146-2 2017 We previously showed that chronic alcohol consumption increased blood pressure (BP), oxidative stress, and 20-hydroxyeicosatetraenoic acid (20-HETE), a vasoconstrictor and pro-inflammatory eicosanoid synthesized by cytochrome P450 (CYP450) enzymes from arachidonic acid. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 107-138 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 215-230 28767146-2 2017 We previously showed that chronic alcohol consumption increased blood pressure (BP), oxidative stress, and 20-hydroxyeicosatetraenoic acid (20-HETE), a vasoconstrictor and pro-inflammatory eicosanoid synthesized by cytochrome P450 (CYP450) enzymes from arachidonic acid. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 107-138 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 232-238 28767146-2 2017 We previously showed that chronic alcohol consumption increased blood pressure (BP), oxidative stress, and 20-hydroxyeicosatetraenoic acid (20-HETE), a vasoconstrictor and pro-inflammatory eicosanoid synthesized by cytochrome P450 (CYP450) enzymes from arachidonic acid. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 140-147 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 215-230 28767146-2 2017 We previously showed that chronic alcohol consumption increased blood pressure (BP), oxidative stress, and 20-hydroxyeicosatetraenoic acid (20-HETE), a vasoconstrictor and pro-inflammatory eicosanoid synthesized by cytochrome P450 (CYP450) enzymes from arachidonic acid. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 140-147 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 232-238 28132967-9 2017 Blood pressure control is mediated at least in part by cytochrome P450 (CYP) enzymes such as CYP4A11 and CYP4F2 that produce 20-hydroxyeicosatetraenoic acid (20-HETE), involved in salt balance in the kidney, and all are known to be altered during Cd exposure. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 125-156 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 55-70 28132967-9 2017 Blood pressure control is mediated at least in part by cytochrome P450 (CYP) enzymes such as CYP4A11 and CYP4F2 that produce 20-hydroxyeicosatetraenoic acid (20-HETE), involved in salt balance in the kidney, and all are known to be altered during Cd exposure. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 125-156 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 72-75 28132967-9 2017 Blood pressure control is mediated at least in part by cytochrome P450 (CYP) enzymes such as CYP4A11 and CYP4F2 that produce 20-hydroxyeicosatetraenoic acid (20-HETE), involved in salt balance in the kidney, and all are known to be altered during Cd exposure. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 158-165 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 55-70 28132967-9 2017 Blood pressure control is mediated at least in part by cytochrome P450 (CYP) enzymes such as CYP4A11 and CYP4F2 that produce 20-hydroxyeicosatetraenoic acid (20-HETE), involved in salt balance in the kidney, and all are known to be altered during Cd exposure. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 158-165 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 72-75 27087514-1 2016 AIM: To better understand the relationship between the interactions among rs17110453, rs751141, and rs9333025 variants and plasma levels of cytochrome P450 (CYP) metabolites, i.e.,20-hydroxyeicosatetraenoic acid (20-HETE), epoxyeicosatrienoic acids (EETs), and dihydroxyeicosatrienoic acids (DiHETEs) in ischemia stroke (IS). 20-hydroxy-5,8,11,14-eicosatetraenoic acid 180-211 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 157-160 22173545-2 2012 Cytochrome P450 (CYP)-derived metabolites of arachidonic acid such as epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), active on vascular tone, endothelial function and renal sodium reapportion, have been identified as candidate mediators in the development of hypertension in several animal models, with remarkable sex-specific effect. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 107-138 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 23466098-6 2013 RESULTS: A significant inverse association was observed between 20-HETE levels (a biomarker of CYP omega-hydroxylase metabolism) and brachial artery flow-mediated dilation (r = -0.255, p = 0.010). 20-hydroxy-5,8,11,14-eicosatetraenoic acid 64-71 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 95-98 23688133-0 2013 CYP4 enzymes as potential drug targets: focus on enzyme multiplicity, inducers and inhibitors, and therapeutic modulation of 20-hydroxyeicosatetraenoic acid (20-HETE) synthase and fatty acid omega-hydroxylase activities. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 125-156 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 158-175 25151892-1 2014 Previous studies have indicated that cytochrome P450 (CYP) metabolites of arachidonic acid (AA), i.e., 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs), play an important role in the regulation of renal tubular and vascular function. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 103-134 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 37-52 25151892-1 2014 Previous studies have indicated that cytochrome P450 (CYP) metabolites of arachidonic acid (AA), i.e., 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs), play an important role in the regulation of renal tubular and vascular function. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 103-134 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 54-57 25151892-1 2014 Previous studies have indicated that cytochrome P450 (CYP) metabolites of arachidonic acid (AA), i.e., 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs), play an important role in the regulation of renal tubular and vascular function. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 136-143 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 37-52 25151892-1 2014 Previous studies have indicated that cytochrome P450 (CYP) metabolites of arachidonic acid (AA), i.e., 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs), play an important role in the regulation of renal tubular and vascular function. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 136-143 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 54-57 24216999-2 2013 Cytochrome P450 (CYP) activity and synthesis of both epoxyeicosatrienoic acids (EETs) and 20-hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE), together with vascular endothelial growth factor (VEGF) and heme oxygenase system (HO) have emerged as important modulators of tumor growth and metastasis. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 134-141 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 24216999-2 2013 Cytochrome P450 (CYP) activity and synthesis of both epoxyeicosatrienoic acids (EETs) and 20-hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE), together with vascular endothelial growth factor (VEGF) and heme oxygenase system (HO) have emerged as important modulators of tumor growth and metastasis. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 134-141 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 17-20 22173545-2 2012 Cytochrome P450 (CYP)-derived metabolites of arachidonic acid such as epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), active on vascular tone, endothelial function and renal sodium reapportion, have been identified as candidate mediators in the development of hypertension in several animal models, with remarkable sex-specific effect. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 107-138 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 17-20 22173545-2 2012 Cytochrome P450 (CYP)-derived metabolites of arachidonic acid such as epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), active on vascular tone, endothelial function and renal sodium reapportion, have been identified as candidate mediators in the development of hypertension in several animal models, with remarkable sex-specific effect. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 140-147 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-15 22173545-2 2012 Cytochrome P450 (CYP)-derived metabolites of arachidonic acid such as epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), active on vascular tone, endothelial function and renal sodium reapportion, have been identified as candidate mediators in the development of hypertension in several animal models, with remarkable sex-specific effect. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 140-147 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 17-20 23013331-6 2012 20-Hydroxyeicosatetraenoic acid (20-HETE) is a vasoconstrictor omega-hydroxylation product of arachidonic acid that is produced by cytochrome P450 (CYP) enzymes, mainly by CYP4A and CYP4F isoforms. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 0-31 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 131-146 23013331-6 2012 20-Hydroxyeicosatetraenoic acid (20-HETE) is a vasoconstrictor omega-hydroxylation product of arachidonic acid that is produced by cytochrome P450 (CYP) enzymes, mainly by CYP4A and CYP4F isoforms. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 0-31 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 148-151 23013331-6 2012 20-Hydroxyeicosatetraenoic acid (20-HETE) is a vasoconstrictor omega-hydroxylation product of arachidonic acid that is produced by cytochrome P450 (CYP) enzymes, mainly by CYP4A and CYP4F isoforms. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 33-40 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 131-146 23013331-6 2012 20-Hydroxyeicosatetraenoic acid (20-HETE) is a vasoconstrictor omega-hydroxylation product of arachidonic acid that is produced by cytochrome P450 (CYP) enzymes, mainly by CYP4A and CYP4F isoforms. 20-hydroxy-5,8,11,14-eicosatetraenoic acid 33-40 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 148-151