PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15968459-1 2005 Control of mammalian gene promoters by the bacterial LacI repressor provides reversible regulation and dose-response levels of derepressed expression by the lactose analog isopropyl thiogalactose (IPTG). Isopropyl Thiogalactoside 197-201 tissue factor pathway inhibitor Mus musculus 53-57 24755679-6 2014 Moreover, transgene expression can be consistently down-regulated by crossing the transgenic mice with mice expressing an inhibitor protein LacI(R), and in one transgenic line, transgene expression could be de-repressed rapidly by the innocuous inducer, IPTG. Isopropyl Thiogalactoside 254-258 tissue factor pathway inhibitor Mus musculus 140-144 21445314-5 2011 However, reporter expression was not uniform and the lacO elements introduced into the Vav-gene promoter only conferred limited repression and reversion of lacI-mediated gene silencing after administration of IPTG. Isopropyl Thiogalactoside 209-213 tissue factor pathway inhibitor Mus musculus 156-160 15968459-2 2005 Here, we show that insertion of LacI-binding sites in the ubiquitous beta-actin promoter confers a strong and dose-dependent IPTG-regulatable expression of transiently transfected reporter genes in mouse embryonic stem (ES) cells expressing LacI. Isopropyl Thiogalactoside 125-129 tissue factor pathway inhibitor Mus musculus 32-36 15968459-2 2005 Here, we show that insertion of LacI-binding sites in the ubiquitous beta-actin promoter confers a strong and dose-dependent IPTG-regulatable expression of transiently transfected reporter genes in mouse embryonic stem (ES) cells expressing LacI. Isopropyl Thiogalactoside 125-129 tissue factor pathway inhibitor Mus musculus 241-245