PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33580697-5	2021	Sch B treatment decreased the expression of TYR, melanocyte-inducing transcription factor (MITF), tyrosinase-related protein (TRP) 1, and TRP2.	schizandrin B	0-5	melanogenesis associated transcription factor	Mus musculus	49-89	
33580697-5	2021	Sch B treatment decreased the expression of TYR, melanocyte-inducing transcription factor (MITF), tyrosinase-related protein (TRP) 1, and TRP2.	schizandrin B	0-5	melanogenesis associated transcription factor	Mus musculus	91-95	
33580697-7	2021	Furthermore, we found that Sch B decreased melanogenesis by downregulating MITF and melanogenic enzymes via MAPK and CREB pathways.	schizandrin B	27-32	melanogenesis associated transcription factor	Mus musculus	75-79	
28241436-7	2017	We also validated that Gomisin N reduced melanin production by repressing the expression of MITF, tyrosinase, TRP-1, and TRP-2 in mouse and human cells as well as in developing zebrafish embryos.	schizandrin B	23-32	melanogenesis associated transcription factor	Mus musculus	92-96	
28695326-9	2017	Gomisin N inhibited the expression of tyrosinase and microphthalmia-associated transcription factor (MITF) in B16F10 cells, while it did not affect cAMP response element binding protein (CREB) phosphorylation.	schizandrin B	0-9	melanogenesis associated transcription factor	Mus musculus	53-99	
28695326-9	2017	Gomisin N inhibited the expression of tyrosinase and microphthalmia-associated transcription factor (MITF) in B16F10 cells, while it did not affect cAMP response element binding protein (CREB) phosphorylation.	schizandrin B	0-9	melanogenesis associated transcription factor	Mus musculus	101-105