PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11353758-1 2001 Ketamine is metabolized by cytochrome P450 (CYP) leading to production of pharmacologically active products and contributing to drug excretion. Ketamine 0-8 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 27-42 11353758-1 2001 Ketamine is metabolized by cytochrome P450 (CYP) leading to production of pharmacologically active products and contributing to drug excretion. Ketamine 0-8 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 44-47 11353758-2 2001 We identified the CYP enzymes involved in the N-demethylation of ketamine enantiomers using pooled human liver microsomes and microsomes from human B-lymphoblastoid cells that expressed CYP enzymes. Ketamine 65-73 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 18-21 11353758-2 2001 We identified the CYP enzymes involved in the N-demethylation of ketamine enantiomers using pooled human liver microsomes and microsomes from human B-lymphoblastoid cells that expressed CYP enzymes. Ketamine 65-73 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 186-189 1361312-5 1992 The purpose of this investigation was to determine the mechanism of DMED inhibition of human cytochrome P-450-mediated microsomal metabolism, using ketamine as a probe. Ketamine 148-156 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 93-109 29888644-0 2018 Regulation of cytochrome P450 gene expression by ketamine: a review. Ketamine 49-57 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 14-29 29888644-2 2018 Ketamine undergoes extensive oxidative metabolism by cytochrome P450 (CYP) enzymes. Ketamine 0-8 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 53-68 29888644-2 2018 Ketamine undergoes extensive oxidative metabolism by cytochrome P450 (CYP) enzymes. Ketamine 0-8 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 70-73 29888644-3 2018 Considerable efforts have been expended to elucidate the ketamine-induced regulation of CYP gene expression. Ketamine 57-65 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 88-91 29888644-5 2018 Understanding how ketamine regulates CYP gene expression is clinically meaningful. Ketamine 18-26 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 37-40 29888644-6 2018 Areas covered: In this article, the authors provide a brief review of clinical applications of ketamine and its metabolism by CYP enzymes. Ketamine 95-103 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 126-129 29888644-7 2018 We discuss the effects of ketamine on the regulation of CYP gene expression, exploring aspects of cytoskeletal remodeling, mitochondrial functions, and calcium homeostasis. Ketamine 26-34 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 56-59 29888644-8 2018 Expert opinion: Ketamine may inhibit CYP gene expression through inhibiting calcium signaling, decreasing ATP levels, producing excessive reactive oxygen species, and subsequently perturbing cytoskeletal dynamics. Ketamine 16-24 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 37-40 21508826-4 2011 The aim of this study was to investigate the effect of CYP enzyme induction by rifampicin on the pharmacokinetics of S-ketamine and its major metabolite, S-norketamine, in healthy volunteers. Ketamine 117-127 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 55-58 19496669-1 2009 OBJECTIVE: To investigate cytochrome P450 (CYP) enzymes involved in metabolism of racemic and S-ketamine in various species and to evaluate metabolic interactions of other analgesics with ketamine. Ketamine 94-104 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 26-41 19496669-1 2009 OBJECTIVE: To investigate cytochrome P450 (CYP) enzymes involved in metabolism of racemic and S-ketamine in various species and to evaluate metabolic interactions of other analgesics with ketamine. Ketamine 94-104 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 43-46 19496669-1 2009 OBJECTIVE: To investigate cytochrome P450 (CYP) enzymes involved in metabolism of racemic and S-ketamine in various species and to evaluate metabolic interactions of other analgesics with ketamine. Ketamine 96-104 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 26-41 19496669-1 2009 OBJECTIVE: To investigate cytochrome P450 (CYP) enzymes involved in metabolism of racemic and S-ketamine in various species and to evaluate metabolic interactions of other analgesics with ketamine. Ketamine 96-104 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 43-46 19496669-10 2009 CONCLUSIONS AND CLINICAL RELEVANCE: Enzymes of the CYP 3A4 family and orthologs of CYP 2C9 were involved in ketamine metabolism in horses, dogs, and humans. Ketamine 108-116 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 51-54 29621538-0 2018 Ketamine and ketamine metabolites as novel estrogen receptor ligands: Induction of cytochrome P450 and AMPA glutamate receptor gene expression. Ketamine 0-8 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 83-98 29621538-0 2018 Ketamine and ketamine metabolites as novel estrogen receptor ligands: Induction of cytochrome P450 and AMPA glutamate receptor gene expression. Ketamine 13-21 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 83-98 20609441-0 2010 Enantioselective capillary electrophoresis for identification and characterization of human cytochrome P450 enzymes which metabolize ketamine and norketamine in vitro. Ketamine 133-141 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 92-107 20609441-3 2010 Enantioselective capillary electrophoresis with multiple isomer sulfated beta-cyclodextrin as chiral selector was used to identify cytochrome P450 enzymes involved in hepatic ketamine and norketamine biotransformation in vitro. Ketamine 175-183 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 131-146 20609441-4 2010 The N-demethylation of ketamine to norketamine and subsequently the biotransformation of norketamine to other metabolites were studied via analysis of alkaline extracts of in vitro incubations of racemic ketamine and racemic norketamine with nine recombinantly expressed human cytochrome P450 enzymes and human liver microsomes. Ketamine 23-31 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 277-292