PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33743158-7 2021 Molecular docking simulations showed that fluorine atom and trifluoromethyl group on PC10 and PC11, respectively, interacted with the substrate cavity of the MAO-B active site. Fluorine 42-50 monoamine oxidase B Homo sapiens 158-163 15027872-2 2004 Synthesis and effect of fluorine substitution at the cyclopropane ring on inhibition of microbial tyramine oxidase. Fluorine 24-32 monoamine oxidase B Homo sapiens 98-114 15027872-8 2004 The presence of a free amino group, directly bonded to the cyclopropane ring, and a fluorine atom in a relationship cis to the amino group were structural features that increased tyramine oxidase inhibition. Fluorine 84-92 monoamine oxidase B Homo sapiens 179-195 8847600-0 1995 SAR studies of fluorine-substituted benzylamines and substituted 2-phenylethylamines as substrates and inactivators of monoamine oxidase B. Fluorine 15-23 monoamine oxidase B Homo sapiens 119-138 32705963-0 2021 Revealing the role of fluorine pharmacophore in chalcone scaffold for shifting the MAO-B selectivity: investigation of a detailed molecular dynamics and quantum chemical study. Fluorine 22-30 monoamine oxidase B Homo sapiens 83-88 33284012-3 2020 The aim of this study was to develop promising fluorine-18 labeled reversible MAO-B PET radioligands and their biological evaluation in vitro by autoradiography. Fluorine 47-55 monoamine oxidase B Homo sapiens 78-83 33284012-11 2020 Radiolabeling of five new fluorine-18 MAO-B reversible inhibitors was successfully accomplished. Fluorine 26-34 monoamine oxidase B Homo sapiens 38-43 32705963-2 2021 Recent study documented that shifting of fluorine atom from para to ortho position on the phenyl B ring of heteroaryl chalcones shown a remarkable shift in the selectivity and potency between MAO-A and MAO-B isoforms. Fluorine 41-49 monoamine oxidase B Homo sapiens 202-207 32705963-3 2021 Despite the large plethora of the design of new selective MAO-B inhibitors, the current paper illustrates the role and orientation of fluorine atom with remarkable MAO-B selectivity of three compounds (O23, O24 and O25), which differ from all other substituents encountered in the chalcone scaffolds is recently reported by our group. Fluorine 134-142 monoamine oxidase B Homo sapiens 58-63 32705963-3 2021 Despite the large plethora of the design of new selective MAO-B inhibitors, the current paper illustrates the role and orientation of fluorine atom with remarkable MAO-B selectivity of three compounds (O23, O24 and O25), which differ from all other substituents encountered in the chalcone scaffolds is recently reported by our group. Fluorine 134-142 monoamine oxidase B Homo sapiens 164-169 28577983-2 2017 Based on our previous report, the methoxy-substituted with fluorine containing chalcones are promising reversible MAO-B inhibitors, while in the present study, a series of methoxylated chalcones (C1-C9) bearing substitution on the para position of ring B was synthesized and evaluated for their human monoamine oxidase inhibitory activity. Fluorine 59-67 monoamine oxidase B Homo sapiens 114-119 30568755-5 2018 The effects of fluorine orientation revealed that SB11 (m-fluorine) showed 28.2 times higher inhibitory activity than SB12 (o-fluorine) against MAO-B. Fluorine 58-66 monoamine oxidase B Homo sapiens 144-149 21923198-5 2011 In addition, the corresponding nonradioactive fluorine-19 compound (13) inhibited recombinant human MAO-B with an IC(50) of 170.5 +- 29 nM but did not inhibit recombinant human MAO-A (IC(50) > 2000 nM), demonstrating its specificity. Fluorine 46-54 monoamine oxidase B Homo sapiens 100-105 22382421-3 2012 It was observed that compound 9b displayed significant MAO-B inhibition activity and selectivity, fluorine substitution plays a key role in the selectivity of MAO-B inhibition, and the styrol-formamido group at position-3" may enhance the activity and selectivity of 8-phenyl-xanthine analogues. Fluorine 98-106 monoamine oxidase B Homo sapiens 159-164