PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31159151-7 2019 Sulfate and methyl conjugates were approximately ten-fold stronger inhibitors (IC50 = 0.2-0.6 muM) of 6-mercaptopurine oxidation than allopurinol (IC50 = 7.0 muM), and induced more potent inhibition compared to quercetin (IC50 = 1.4 muM). Mercaptopurine 102-118 latexin Homo sapiens 94-97 8645339-10 1996 In the intravenous 6MP group, 6-methylmercaptopurine, its riboside, and 6-methylmercapto-8-hydroxypurine were detectable in plasma in concentrations of 0.3-2.6 muM (6MP steady state levels: 11.6 muM). Mercaptopurine 19-22 latexin Homo sapiens 160-163 8645339-10 1996 In the intravenous 6MP group, 6-methylmercaptopurine, its riboside, and 6-methylmercapto-8-hydroxypurine were detectable in plasma in concentrations of 0.3-2.6 muM (6MP steady state levels: 11.6 muM). Mercaptopurine 19-22 latexin Homo sapiens 195-198 31646218-6 2019 This unique signature was applied in voltammetric detection of 6-MP in blood serum, human urine, and pharmaceutical formulation (tablet) by a considerable high sensitivity of 0.074, 0.058, and 0.036 muA/muM and a detection limit of 87, 97, and 37 nM, respectively. Mercaptopurine 63-67 latexin Homo sapiens 203-206 31159151-7 2019 Sulfate and methyl conjugates were approximately ten-fold stronger inhibitors (IC50 = 0.2-0.6 muM) of 6-mercaptopurine oxidation than allopurinol (IC50 = 7.0 muM), and induced more potent inhibition compared to quercetin (IC50 = 1.4 muM). Mercaptopurine 102-118 latexin Homo sapiens 158-161 31159151-7 2019 Sulfate and methyl conjugates were approximately ten-fold stronger inhibitors (IC50 = 0.2-0.6 muM) of 6-mercaptopurine oxidation than allopurinol (IC50 = 7.0 muM), and induced more potent inhibition compared to quercetin (IC50 = 1.4 muM). Mercaptopurine 102-118 latexin Homo sapiens 158-161 30774864-3 2019 We have previously reported in vitro that the oxidative metabolites of 6TP, specifically 6-thiouric acid (6TU, K i 7 muM), are potent inhibitors of UDP-glucose dehydrogenase (UDPGDH), an enzyme that is responsible for the formation of UDP-glucuronic acid (UDPGA), an essential substrate that is used in detoxification processes in the liver. Mercaptopurine 71-74 latexin Homo sapiens 117-120 29283382-8 2017 The inhibitory constant of mercaptopurine (16 muM) was comparable to that of the well-known inhibitor kojic acid (13 muM). Mercaptopurine 27-41 latexin Homo sapiens 46-49 29283382-8 2017 The inhibitory constant of mercaptopurine (16 muM) was comparable to that of the well-known inhibitor kojic acid (13 muM). Mercaptopurine 27-41 latexin Homo sapiens 117-120