PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25007187-1	2014	BACKGROUND: The aim of this study is to analyze polymorphisms in genes involved in 6-mercaptopurine detoxification (TPMT); methotrexate (MTX) metabolism including ABCB1 (or MDR1), ABCC2, SLC19A1 (or RFC1), and SLCO1B1; and the MTX effect mainly MTHFR and TYMS, and to assess whether these polymorphisms are predictors of treatment toxicity and/or MTX clearance.	Mercaptopurine	83-99	thymidylate synthetase	Homo sapiens	255-259	
22838948-4	2012	The following synergetic interactions appeared to increase the toxicity of 6-mercaptopurine: TPMT*12 x RFC1 G80A; TPMT CTTAT haplotype x RFC1 G80A; TPMT CTTAT haplotype x RFC1 G80A x TYMS 2R3R.	Mercaptopurine	75-91	thymidylate synthetase	Homo sapiens	183-187