PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22838948-4 2012 The following synergetic interactions appeared to increase the toxicity of 6-mercaptopurine: TPMT*12 x RFC1 G80A; TPMT CTTAT haplotype x RFC1 G80A; TPMT CTTAT haplotype x RFC1 G80A x TYMS 2R3R. Mercaptopurine 75-91 thymidylate synthetase Homo sapiens 183-187 25007187-1 2014 BACKGROUND: The aim of this study is to analyze polymorphisms in genes involved in 6-mercaptopurine detoxification (TPMT); methotrexate (MTX) metabolism including ABCB1 (or MDR1), ABCC2, SLC19A1 (or RFC1), and SLCO1B1; and the MTX effect mainly MTHFR and TYMS, and to assess whether these polymorphisms are predictors of treatment toxicity and/or MTX clearance. Mercaptopurine 83-99 thymidylate synthetase Homo sapiens 255-259