PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29058362-0	2018	The ketone body metabolite beta-hydroxybutyrate induces an antidepression-associated ramification of microglia via HDACs inhibition-triggered Akt-small RhoGTPase activation.	3-Hydroxybutyric Acid	27-47	thymoma viral proto-oncogene 1	Mus musculus	142-145	
29058362-5	2018	The protein kinase B (Akt)-small RhoGTPase axis was found to mediate the effect of BHB on microglial shape change, as (i) BHB activated the microglial small RhoGTPase (Rac1, Cdc42) and Akt; (ii) Akt and Rac1-Cdc42 inhibition abolished the pro-ramification effect of BHB; (iii) Akt inhibition prevented the activation of Rac1-Cdc42 induced by BHB treatment.	3-Hydroxybutyric Acid	122-125	thymoma viral proto-oncogene 1	Mus musculus	185-188	
29058362-5	2018	The protein kinase B (Akt)-small RhoGTPase axis was found to mediate the effect of BHB on microglial shape change, as (i) BHB activated the microglial small RhoGTPase (Rac1, Cdc42) and Akt; (ii) Akt and Rac1-Cdc42 inhibition abolished the pro-ramification effect of BHB; (iii) Akt inhibition prevented the activation of Rac1-Cdc42 induced by BHB treatment.	3-Hydroxybutyric Acid	122-125	thymoma viral proto-oncogene 1	Mus musculus	185-188	
29058362-5	2018	The protein kinase B (Akt)-small RhoGTPase axis was found to mediate the effect of BHB on microglial shape change, as (i) BHB activated the microglial small RhoGTPase (Rac1, Cdc42) and Akt; (ii) Akt and Rac1-Cdc42 inhibition abolished the pro-ramification effect of BHB; (iii) Akt inhibition prevented the activation of Rac1-Cdc42 induced by BHB treatment.	3-Hydroxybutyric Acid	122-125	thymoma viral proto-oncogene 1	Mus musculus	22-25	
29058362-5	2018	The protein kinase B (Akt)-small RhoGTPase axis was found to mediate the effect of BHB on microglial shape change, as (i) BHB activated the microglial small RhoGTPase (Rac1, Cdc42) and Akt; (ii) Akt and Rac1-Cdc42 inhibition abolished the pro-ramification effect of BHB; (iii) Akt inhibition prevented the activation of Rac1-Cdc42 induced by BHB treatment.	3-Hydroxybutyric Acid	122-125	thymoma viral proto-oncogene 1	Mus musculus	185-188	
29058362-5	2018	The protein kinase B (Akt)-small RhoGTPase axis was found to mediate the effect of BHB on microglial shape change, as (i) BHB activated the microglial small RhoGTPase (Rac1, Cdc42) and Akt; (ii) Akt and Rac1-Cdc42 inhibition abolished the pro-ramification effect of BHB; (iii) Akt inhibition prevented the activation of Rac1-Cdc42 induced by BHB treatment.	3-Hydroxybutyric Acid	122-125	thymoma viral proto-oncogene 1	Mus musculus	185-188	
29058362-5	2018	The protein kinase B (Akt)-small RhoGTPase axis was found to mediate the effect of BHB on microglial shape change, as (i) BHB activated the microglial small RhoGTPase (Rac1, Cdc42) and Akt; (ii) Akt and Rac1-Cdc42 inhibition abolished the pro-ramification effect of BHB; (iii) Akt inhibition prevented the activation of Rac1-Cdc42 induced by BHB treatment.	3-Hydroxybutyric Acid	122-125	thymoma viral proto-oncogene 1	Mus musculus	185-188	
29058362-7	2018	Functionally, Akt inhibition was found to abrogate the effects of BHB on microglial polarization and phagocytosis.	3-Hydroxybutyric Acid	66-69	thymoma viral proto-oncogene 1	Mus musculus	14-17	
29058362-8	2018	In neuroinflammatory models induced by lipopolysaccharide (LPS) or chronic unpredictable stress (CUS), BHB prevented the microglial process retraction and depressive-like behaviors, and these effects were abolished by Akt inhibition.	3-Hydroxybutyric Acid	103-106	thymoma viral proto-oncogene 1	Mus musculus	218-221	
29058362-5	2018	The protein kinase B (Akt)-small RhoGTPase axis was found to mediate the effect of BHB on microglial shape change, as (i) BHB activated the microglial small RhoGTPase (Rac1, Cdc42) and Akt; (ii) Akt and Rac1-Cdc42 inhibition abolished the pro-ramification effect of BHB; (iii) Akt inhibition prevented the activation of Rac1-Cdc42 induced by BHB treatment.	3-Hydroxybutyric Acid	83-86	thymoma viral proto-oncogene 1	Mus musculus	22-25	
29058362-5	2018	The protein kinase B (Akt)-small RhoGTPase axis was found to mediate the effect of BHB on microglial shape change, as (i) BHB activated the microglial small RhoGTPase (Rac1, Cdc42) and Akt; (ii) Akt and Rac1-Cdc42 inhibition abolished the pro-ramification effect of BHB; (iii) Akt inhibition prevented the activation of Rac1-Cdc42 induced by BHB treatment.	3-Hydroxybutyric Acid	83-86	thymoma viral proto-oncogene 1	Mus musculus	185-188	
29058362-5	2018	The protein kinase B (Akt)-small RhoGTPase axis was found to mediate the effect of BHB on microglial shape change, as (i) BHB activated the microglial small RhoGTPase (Rac1, Cdc42) and Akt; (ii) Akt and Rac1-Cdc42 inhibition abolished the pro-ramification effect of BHB; (iii) Akt inhibition prevented the activation of Rac1-Cdc42 induced by BHB treatment.	3-Hydroxybutyric Acid	83-86	thymoma viral proto-oncogene 1	Mus musculus	185-188	
29058362-5	2018	The protein kinase B (Akt)-small RhoGTPase axis was found to mediate the effect of BHB on microglial shape change, as (i) BHB activated the microglial small RhoGTPase (Rac1, Cdc42) and Akt; (ii) Akt and Rac1-Cdc42 inhibition abolished the pro-ramification effect of BHB; (iii) Akt inhibition prevented the activation of Rac1-Cdc42 induced by BHB treatment.	3-Hydroxybutyric Acid	83-86	thymoma viral proto-oncogene 1	Mus musculus	185-188	
29058362-5	2018	The protein kinase B (Akt)-small RhoGTPase axis was found to mediate the effect of BHB on microglial shape change, as (i) BHB activated the microglial small RhoGTPase (Rac1, Cdc42) and Akt; (ii) Akt and Rac1-Cdc42 inhibition abolished the pro-ramification effect of BHB; (iii) Akt inhibition prevented the activation of Rac1-Cdc42 induced by BHB treatment.	3-Hydroxybutyric Acid	122-125	thymoma viral proto-oncogene 1	Mus musculus	22-25	
29058362-5	2018	The protein kinase B (Akt)-small RhoGTPase axis was found to mediate the effect of BHB on microglial shape change, as (i) BHB activated the microglial small RhoGTPase (Rac1, Cdc42) and Akt; (ii) Akt and Rac1-Cdc42 inhibition abolished the pro-ramification effect of BHB; (iii) Akt inhibition prevented the activation of Rac1-Cdc42 induced by BHB treatment.	3-Hydroxybutyric Acid	122-125	thymoma viral proto-oncogene 1	Mus musculus	185-188	
29058362-5	2018	The protein kinase B (Akt)-small RhoGTPase axis was found to mediate the effect of BHB on microglial shape change, as (i) BHB activated the microglial small RhoGTPase (Rac1, Cdc42) and Akt; (ii) Akt and Rac1-Cdc42 inhibition abolished the pro-ramification effect of BHB; (iii) Akt inhibition prevented the activation of Rac1-Cdc42 induced by BHB treatment.	3-Hydroxybutyric Acid	122-125	thymoma viral proto-oncogene 1	Mus musculus	185-188	
29058362-5	2018	The protein kinase B (Akt)-small RhoGTPase axis was found to mediate the effect of BHB on microglial shape change, as (i) BHB activated the microglial small RhoGTPase (Rac1, Cdc42) and Akt; (ii) Akt and Rac1-Cdc42 inhibition abolished the pro-ramification effect of BHB; (iii) Akt inhibition prevented the activation of Rac1-Cdc42 induced by BHB treatment.	3-Hydroxybutyric Acid	122-125	thymoma viral proto-oncogene 1	Mus musculus	185-188	
29058362-5	2018	The protein kinase B (Akt)-small RhoGTPase axis was found to mediate the effect of BHB on microglial shape change, as (i) BHB activated the microglial small RhoGTPase (Rac1, Cdc42) and Akt; (ii) Akt and Rac1-Cdc42 inhibition abolished the pro-ramification effect of BHB; (iii) Akt inhibition prevented the activation of Rac1-Cdc42 induced by BHB treatment.	3-Hydroxybutyric Acid	122-125	thymoma viral proto-oncogene 1	Mus musculus	22-25	
29058362-5	2018	The protein kinase B (Akt)-small RhoGTPase axis was found to mediate the effect of BHB on microglial shape change, as (i) BHB activated the microglial small RhoGTPase (Rac1, Cdc42) and Akt; (ii) Akt and Rac1-Cdc42 inhibition abolished the pro-ramification effect of BHB; (iii) Akt inhibition prevented the activation of Rac1-Cdc42 induced by BHB treatment.	3-Hydroxybutyric Acid	122-125	thymoma viral proto-oncogene 1	Mus musculus	185-188	
21982775-1	2011	Recently it was demonstrated that the ketone body beta-hydroxybutyrate (BOH) inhibits insulin-mediated glucose transport in isolated oxidative muscle, which was associated with decreased phosphorylation of Akt/protein kinase B.	3-Hydroxybutyric Acid	50-70	thymoma viral proto-oncogene 1	Mus musculus	206-209