PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27935584-8	2017	Moreover, we showed that either knockdown of mTOR or inhibition of mTORC1 with rapamycin increases the expression of HMGCS2 in intestinal cells in vitro and in vivo, suggesting a possible cross-talk between mTOR and HMGCS2/betaHB signaling in intestinal cells.	3-Hydroxybutyric Acid	223-229	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2	Mus musculus	117-123	
28528772-7	2017	A rise in 3-hydroxy-3-methylglutary-CoA synthase 2 (HMGCS2), a key enzyme for catalyzing beta-hydroxybutyric acid production, was observed in early AD mice.	3-Hydroxybutyric Acid	89-113	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2	Mus musculus	52-58	
27935584-8	2017	Moreover, we showed that either knockdown of mTOR or inhibition of mTORC1 with rapamycin increases the expression of HMGCS2 in intestinal cells in vitro and in vivo, suggesting a possible cross-talk between mTOR and HMGCS2/betaHB signaling in intestinal cells.	3-Hydroxybutyric Acid	223-229	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2	Mus musculus	216-222	
20851857-6	2011	Coincident with the observed changes in fetal growth, we noted an elevation in maternal hepatic triglyceride content, expression of the ketogenic 3-hydroxy-3-methylglutaryl-CoA synthase 2 (Hmgcs2) and circulating plasma beta-hydroxybutyrate (BOHB).	3-Hydroxybutyric Acid	220-240	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2	Mus musculus	189-195	
20959534-5	2011	Consistently, the activity of HMGCS2 in kidneys and 24-h urinary excretion of the ketone body beta-hydroxybutyrate (beta-HB) were significantly increased in db/db mice.	3-Hydroxybutyric Acid	94-114	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2	Mus musculus	30-36	
21109197-3	2010	HMGCS2 is the rate-limiting step in beta-hydroxybutyrate synthesis and is hyperacetylated at lysines 310, 447, and 473 in the absence of SIRT3.	3-Hydroxybutyric Acid	36-56	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2	Mus musculus	0-6