PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17386920-0	2007	Assay of angiotensin I-converting enzyme-inhibiting activity based on the detection of 3-hydroxybutyric acid.	3-Hydroxybutyric Acid	87-108	angiotensin I converting enzyme	Homo sapiens	9-40	
17386920-4	2007	Under the actions of ACE and aminoacylase, 3HB-GGG is cleaved into amino acids (Gly and Gly-Gly) and 3-hydroxybutyric acid (3HB).	3-Hydroxybutyric Acid	101-122	angiotensin I converting enzyme	Homo sapiens	21-24	
17386920-4	2007	Under the actions of ACE and aminoacylase, 3HB-GGG is cleaved into amino acids (Gly and Gly-Gly) and 3-hydroxybutyric acid (3HB).	3-Hydroxybutyric Acid	43-46	angiotensin I converting enzyme	Homo sapiens	21-24	
17386920-5	2007	The assay conditions were optimized and applied to monitor the ACE inhibitory activity in terms of 3HB measured using an F-kit.	3-Hydroxybutyric Acid	99-102	angiotensin I converting enzyme	Homo sapiens	63-66	
17386920-6	2007	Under the optimum assay parameters-ACE (0.2 U/ml) and aminoacylase (172 kU/ml) incubated with 3HB-GGG (3.4 mg/ml) at 37 degrees C for 30 min-the Gly-Gly and Gly cleaved from 3HB-GGG by enzymes was able to be identified, affirming the feasibility of substituting 3HB-GGG for the conventional substrate HHL.	3-Hydroxybutyric Acid	94-97	angiotensin I converting enzyme	Homo sapiens	35-38	
31648544-4	2020	Furthermore, BHB inhibited the upregulation of HDAC1/2/3 expression and downregulation of histone acetylation (Ace-H3K9 and Ace-H4K12) levels in Abeta-treated cells.	3-Hydroxybutyric Acid	13-16	angiotensin I converting enzyme	Homo sapiens	111-114	
31648544-4	2020	Furthermore, BHB inhibited the upregulation of HDAC1/2/3 expression and downregulation of histone acetylation (Ace-H3K9 and Ace-H4K12) levels in Abeta-treated cells.	3-Hydroxybutyric Acid	13-16	angiotensin I converting enzyme	Homo sapiens	124-127	
18689950-0	2008	Assay of angiotensin I-converting enzyme-inhibiting activity based on the detection of 3-hydroxybutyrate with water-soluble tetrazolium salt.	3-Hydroxybutyric Acid	87-104	angiotensin I converting enzyme	Homo sapiens	9-40	
18689950-2	2008	In this study, an ACE-inhibiting assay was improved by the use of a water-soluble tetrazolium salt, 4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate sodium salt (WST-1), for the detection of 3-hydroxybutyrate, derived from 3HB-GGG.	3-Hydroxybutyric Acid	221-238	angiotensin I converting enzyme	Homo sapiens	18-21