PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25580562-0	2015	beta-Hydroxybutyric acid inhibits growth hormone-releasing hormone synthesis and secretion through the GPR109A/extracellular signal-regulated 1/2 signalling pathway in the hypothalamus.	3-Hydroxybutyric Acid	0-24	hydroxycarboxylic acid receptor 2	Rattus norvegicus	103-110	
32765945-0	2020	beta-Hydroxybutyrate Suppresses Lipid Accumulation in Aged Liver through GPR109A-mediated Signaling.	3-Hydroxybutyric Acid	0-20	hydroxycarboxylic acid receptor 2	Rattus norvegicus	73-80	
32765945-3	2020	BHB is a ligand of GPR109A, which inhibits lipolysis and exerts anti-inflammatory effects on cells.	3-Hydroxybutyric Acid	0-3	hydroxycarboxylic acid receptor 2	Rattus norvegicus	19-26	
32765945-6	2020	Here, we used aged rats that were administered with BHB and compared the modulatory effects of BHB through the GPR109A/AMPK pathway on the hepatic endoplasmic reticulum (ER) stress and lipid accumulation to CR rats.	3-Hydroxybutyric Acid	95-98	hydroxycarboxylic acid receptor 2	Rattus norvegicus	111-118	
32765945-7	2020	BHB caused suppression of hepatic ER stress and lipid accumulation through GPR109A/AMPK pathway in the aged rats.	3-Hydroxybutyric Acid	0-3	hydroxycarboxylic acid receptor 2	Rattus norvegicus	75-82	
25580562-4	2015	We hypothesised that BHBA regulates GHRH via GPR109A and its downstream signals.	3-Hydroxybutyric Acid	21-25	hydroxycarboxylic acid receptor 2	Rattus norvegicus	45-52	
25580562-13	2015	These results strongly suggest that BHBA directly regulates GHRH synthesis and secretion via the GPR109A/ERK1/2 MAPK pathway, and also that Gsh-1 is essential for this function.	3-Hydroxybutyric Acid	36-40	hydroxycarboxylic acid receptor 2	Rattus norvegicus	97-104	
25595674-0	2015	Anti-inflammatory effects of BHBA in both in vivo and in vitro Parkinson"s disease models are mediated by GPR109A-dependent mechanisms.	3-Hydroxybutyric Acid	29-33	hydroxycarboxylic acid receptor 2	Rattus norvegicus	106-113	
25595674-12	2015	Our in vitro mechanistic study revealed that the inhibitory effect of BHBA on microglia was mediated by G-protein-coupled receptor 109A (GPR109A) and involved the NF-kappaB signaling pathway, causing the inhibition of pro-inflammatory enzyme (iNOS and COX-2) and pro-inflammatory cytokine (TNF-alpha, IL-1beta, and IL-6) production.	3-Hydroxybutyric Acid	70-74	hydroxycarboxylic acid receptor 2	Rattus norvegicus	104-135	
25595674-12	2015	Our in vitro mechanistic study revealed that the inhibitory effect of BHBA on microglia was mediated by G-protein-coupled receptor 109A (GPR109A) and involved the NF-kappaB signaling pathway, causing the inhibition of pro-inflammatory enzyme (iNOS and COX-2) and pro-inflammatory cytokine (TNF-alpha, IL-1beta, and IL-6) production.	3-Hydroxybutyric Acid	70-74	hydroxycarboxylic acid receptor 2	Rattus norvegicus	137-144