PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22357971-0	2012	The ketone body beta-hydroxybutyric acid influences agouti-related peptide expression via AMP-activated protein kinase in hypothalamic GT1-7 cells.	3-Hydroxybutyric Acid	16-40	agouti related neuropeptide	Mus musculus	52-74	
22357971-5	2012	After 4 h, BHBA treatment also increased Agrp mRNA expression.	3-Hydroxybutyric Acid	11-15	agouti related neuropeptide	Mus musculus	41-45	
22357971-6	2012	This increase was prevented by preincubation with the AMPK inhibitor Compound C. The inhibition of MCT1 activity by p-hydroxymercuribenzoate suppressed BHBA-stimulated AMPK phosphorylation but did not prevent BHBA-induced Agrp mRNA expression.	3-Hydroxybutyric Acid	152-156	agouti related neuropeptide	Mus musculus	222-226	
22357971-8	2012	Under conditions of 5.5 mM glucose, however, BHBA marginally increased intracellular calcium but significantly decreased AMPK phosphorylation and Agrp mRNA expression, demonstrating that under physiological conditions BHBA reduces central orexigenic signalling.	3-Hydroxybutyric Acid	45-49	agouti related neuropeptide	Mus musculus	146-150	
22357971-8	2012	Under conditions of 5.5 mM glucose, however, BHBA marginally increased intracellular calcium but significantly decreased AMPK phosphorylation and Agrp mRNA expression, demonstrating that under physiological conditions BHBA reduces central orexigenic signalling.	3-Hydroxybutyric Acid	218-222	agouti related neuropeptide	Mus musculus	146-150