PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35151471-0	2022	beta-Hydroxybutyrate inhibits apoptosis in bovine neutrophils through activating ERK1/2 and AKT signaling pathways.	3-Hydroxybutyric Acid	0-20	AKT serine/threonine kinase 1	Bos taurus	92-95	
34538494-13	2021	In addition, BHB treatment increased phosphorylation of IRS1 and decreased phosphorylation of AKT and GSK3beta, and upregulated abundance of gluconeogenic genes (phosphoenolpyruvate carboxykinase and glucose-6-phosphatase).	3-Hydroxybutyric Acid	13-16	AKT serine/threonine kinase 1	Bos taurus	94-97	
35151471-10	2022	In addition, both SCH772984 (an inhibitor of the ERK1/2 signaling pathway) and MK-2206 (an inhibitor of the AKT signaling pathway) alleviated the BHB-induced anti-apoptotic function of the Bcl-2 family and the inhibition of MMP.	3-Hydroxybutyric Acid	146-149	AKT serine/threonine kinase 1	Bos taurus	108-111	
35151471-11	2022	Overall, our data demonstrated that high concentrations of BHB inhibit apoptosis in bovine neutrophils by activating the ERK1/2 and AKT signaling pathways.	3-Hydroxybutyric Acid	59-62	AKT serine/threonine kinase 1	Bos taurus	132-135	
32719460-0	2020	beta-hydroxybutyrate and hydroxycarboxylic acid receptor 2 agonists activate the AKT, ERK and AMPK pathways, which are involved in bovine neutrophil chemotaxis.	3-Hydroxybutyric Acid	0-20	AKT serine/threonine kinase 1	Bos taurus	81-84	
32719460-5	2020	We also observed that BHB and HCA2 agonists induced calcium release and phosphorylation of AKT, ERK 1/2 and AMPKalpha.	3-Hydroxybutyric Acid	22-25	AKT serine/threonine kinase 1	Bos taurus	91-94