PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25686106-10	2015	In vivo, BHB or a ketogenic diet attenuates caspase-1 activation and IL-1beta secretion in mouse models of NLRP3-mediated diseases such as Muckle-Wells syndrome, familial cold autoinflammatory syndrome and urate crystal-induced peritonitis.	3-Hydroxybutyric Acid	9-12	NLR family, pyrin domain containing 3	Mus musculus	107-112	
34880753-8	2021	BHBA significantly improved water maze performance; increased the ACh content, SOD activity, and SIRT1 expression; and decreased AChE and LDH activity, ROS, MDA, IL-1beta, TNF-alpha contents, and NLRP3 expression.	3-Hydroxybutyric Acid	0-4	NLR family, pyrin domain containing 3	Mus musculus	196-201	
33609086-1	2021	AIM: This study aimed to assess the response of endogenous beta-hydroxybutyrate to psychological stress, and its association with nucleotide-binding domain, leucine-rich repeat, pyrin domain-containing 3 (NLRP3) inflammasome, and stress-induced behavior.	3-Hydroxybutyric Acid	59-79	NLR family, pyrin domain containing 3	Mus musculus	205-210	
33609086-10	2021	CONCLUSIONS: The increased blood beta-hydroxybutyrate levels due to psychological stress correlate with the active NLRP3 levels in the prefrontal cortex, suggesting that the increased beta-hydroxybutyrate levels due to stress may reflect a reaction to brain inflammation.	3-Hydroxybutyric Acid	33-53	NLR family, pyrin domain containing 3	Mus musculus	115-120	
33609086-10	2021	CONCLUSIONS: The increased blood beta-hydroxybutyrate levels due to psychological stress correlate with the active NLRP3 levels in the prefrontal cortex, suggesting that the increased beta-hydroxybutyrate levels due to stress may reflect a reaction to brain inflammation.	3-Hydroxybutyric Acid	184-204	NLR family, pyrin domain containing 3	Mus musculus	115-120	
33609086-6	2021	A correlation was found between the increased beta-hydroxybutyrate levels in the blood and the active NLRP3 levels in the prefrontal cortex.	3-Hydroxybutyric Acid	46-66	NLR family, pyrin domain containing 3	Mus musculus	102-107	
32694683-2	2020	A widely used ketogenic diet (KD), which is extremely high in fat with very low carbohydrates, drives the host into using beta-hydroxybutyrate for the production of ATP and lowers NLRP3-mediated inflammation.	3-Hydroxybutyric Acid	122-142	NLR family, pyrin domain containing 3	Mus musculus	180-185	
32493060-8	2020	Lastly, addition of beta-hydroxybutyrate to isolated hearts was associated with reduced NLRP3 (nucleotide-binding domain-like receptor protein 3)-inflammasome activation, which has been previously shown to play a role in contributing to HF-induced cardiac inflammation.	3-Hydroxybutyric Acid	20-40	NLR family, pyrin domain containing 3	Mus musculus	88-93	
32493060-8	2020	Lastly, addition of beta-hydroxybutyrate to isolated hearts was associated with reduced NLRP3 (nucleotide-binding domain-like receptor protein 3)-inflammasome activation, which has been previously shown to play a role in contributing to HF-induced cardiac inflammation.	3-Hydroxybutyric Acid	20-40	NLR family, pyrin domain containing 3	Mus musculus	95-144	
32958021-5	2020	Therefore, we tested if BHB inhibition of the NLRP3 inflammasome reduces overall AD pathology in the 5XFAD mouse model of AD.	3-Hydroxybutyric Acid	24-27	NLR family, pyrin domain containing 3	Mus musculus	46-51	
32958021-8	2020	Taken together, our findings demonstrate that BHB reduces AD pathology by inhibiting NLRP3 inflammasome activation.	3-Hydroxybutyric Acid	46-49	NLR family, pyrin domain containing 3	Mus musculus	85-90	
29241624-5	2018	NLRP3 inhibition using the beta-hydroxybutyrate precursor 1,3-butanediol protected such mice from nephrocalcinosis-related CKD.	3-Hydroxybutyric Acid	27-47	NLR family, pyrin domain containing 3	Mus musculus	0-5	
30657794-0	2019	The activation of retinal HCA2 receptors by systemic beta-hydroxybutyrate inhibits diabetic retinal damage through reduction of endoplasmic reticulum stress and the NLRP3 inflammasome.	3-Hydroxybutyric Acid	53-73	NLR family, pyrin domain containing 3	Mus musculus	165-170	
30657794-8	2019	In fact, the elevated levels of retinal NLRP3 inflammasome activation markers (NLRP3, ASC, caspase-1) and of the relative proinflammatory cytokines (IL-1beta, IL-18) were significantly reduced by 50 mg/kg and 100 mg/kg beta-hydroxybutyrate treatment.	3-Hydroxybutyric Acid	219-239	NLR family, pyrin domain containing 3	Mus musculus	40-45	
29662437-9	2018	Furthermore, BHB decreased reactive oxygen species (ROS) generation, inhibited ROS-NLRP3 pathway in OGD/R-treated cells, and suppressed ER stress-induced NLRP3 inflammasome activation.	3-Hydroxybutyric Acid	13-16	NLR family, pyrin domain containing 3	Mus musculus	83-88	
29662437-9	2018	Furthermore, BHB decreased reactive oxygen species (ROS) generation, inhibited ROS-NLRP3 pathway in OGD/R-treated cells, and suppressed ER stress-induced NLRP3 inflammasome activation.	3-Hydroxybutyric Acid	13-16	NLR family, pyrin domain containing 3	Mus musculus	154-159