PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34628106-0 2021 beta-hydroxybutyrate suppresses NLRP3 inflammasome-mediated placental inflammation and lipopolysaccharide-induced fetal absorption. 3-Hydroxybutyric Acid 0-20 NLR family pyrin domain containing 3 Homo sapiens 32-37 34628106-3 2021 The ketone body beta-hydroxybutyrate (BHB) can suppress NLRP3 inflammasome activation and improve various inflammatory diseases. 3-Hydroxybutyric Acid 16-36 NLR family pyrin domain containing 3 Homo sapiens 56-61 34628106-3 2021 The ketone body beta-hydroxybutyrate (BHB) can suppress NLRP3 inflammasome activation and improve various inflammatory diseases. 3-Hydroxybutyric Acid 38-41 NLR family pyrin domain containing 3 Homo sapiens 56-61 34628106-4 2021 Therefore, we hypothesized that BHB could suppress activation of the NLRP3 inflammasome in the placenta, resulting in the improvement of pregnancy complications. 3-Hydroxybutyric Acid 32-35 NLR family pyrin domain containing 3 Homo sapiens 69-74 32358544-6 2020 Ex vivo experiments with macrophages verify the inhibitory effects of high BHB and low insulin levels on NLRP3 inflammasome activation. 3-Hydroxybutyric Acid 75-78 NLR family pyrin domain containing 3 Homo sapiens 105-110 35433045-2 2022 The ketone body beta-hydroxybutyrate (betaHB) suppresses the NLRP3 inflammasome and alters intracellular signalling pathways in vitro and in animal models; however, this effect has not yet been shown in vivo in humans. 3-Hydroxybutyric Acid 16-36 NLR family pyrin domain containing 3 Homo sapiens 61-66 35433045-2 2022 The ketone body beta-hydroxybutyrate (betaHB) suppresses the NLRP3 inflammasome and alters intracellular signalling pathways in vitro and in animal models; however, this effect has not yet been shown in vivo in humans. 3-Hydroxybutyric Acid 38-44 NLR family pyrin domain containing 3 Homo sapiens 61-66 35264201-7 2022 Mechanistically, the ketone body beta-hydroxybutyrate (BHB) deactivated the activation of NLRP3 inflammasome triggered by CoCrMo alloy particles. 3-Hydroxybutyric Acid 33-53 NLR family pyrin domain containing 3 Homo sapiens 90-95 35264201-7 2022 Mechanistically, the ketone body beta-hydroxybutyrate (BHB) deactivated the activation of NLRP3 inflammasome triggered by CoCrMo alloy particles. 3-Hydroxybutyric Acid 55-58 NLR family pyrin domain containing 3 Homo sapiens 90-95 32958021-4 2020 One of the ketone bodies produced as a result of ketogenesis, beta-hydroxybutyrate (BHB), is known to inhibit NLRP3 inflammasome activation. 3-Hydroxybutyric Acid 62-82 NLR family pyrin domain containing 3 Homo sapiens 110-115 32958021-4 2020 One of the ketone bodies produced as a result of ketogenesis, beta-hydroxybutyrate (BHB), is known to inhibit NLRP3 inflammasome activation. 3-Hydroxybutyric Acid 84-87 NLR family pyrin domain containing 3 Homo sapiens 110-115 32125791-0 2020 Prefrontal cortex infusion of beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, produces antidepressant-like effects in a rodent model of depression. 3-Hydroxybutyric Acid 30-50 NLR family pyrin domain containing 3 Homo sapiens 66-71 28836226-4 2017 Recently the ketone body, beta-hydroxy butyrate (BHB), was shown to efficiently inhibit the NLRP3 inflammasome in macrophages, and in vivo models of inflammatory disease. 3-Hydroxybutyric Acid 26-47 NLR family pyrin domain containing 3 Homo sapiens 92-97 32209983-2 2020 Mechanistic studies have shown that beta-hydroxybutyrate (OHB) attenuates activation of NLRP3, but human data are limited. 3-Hydroxybutyric Acid 36-56 NLR family pyrin domain containing 3 Homo sapiens 88-93 30912285-1 2019 SCOPE: Cell culture studies indicate that the ketone beta-hydroxybutyrate (beta-OHB) directly inhibits the NLRP3 inflammasome, a key regulator of inflammation. 3-Hydroxybutyric Acid 53-73 NLR family pyrin domain containing 3 Homo sapiens 107-112 30218403-2 2018 Beta-hydroxybutyrate (BHB) is a ketone body that has recently been reported to exert anti-inflammatory effects via inhibition of NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasome. 3-Hydroxybutyric Acid 0-20 NLR family pyrin domain containing 3 Homo sapiens 129-172 30218403-2 2018 Beta-hydroxybutyrate (BHB) is a ketone body that has recently been reported to exert anti-inflammatory effects via inhibition of NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasome. 3-Hydroxybutyric Acid 0-20 NLR family pyrin domain containing 3 Homo sapiens 174-179 30218403-2 2018 Beta-hydroxybutyrate (BHB) is a ketone body that has recently been reported to exert anti-inflammatory effects via inhibition of NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasome. 3-Hydroxybutyric Acid 22-25 NLR family pyrin domain containing 3 Homo sapiens 129-172 30218403-2 2018 Beta-hydroxybutyrate (BHB) is a ketone body that has recently been reported to exert anti-inflammatory effects via inhibition of NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasome. 3-Hydroxybutyric Acid 22-25 NLR family pyrin domain containing 3 Homo sapiens 174-179 30218403-4 2018 Our results indicated that administration of BHB suppressed C6 cells migration and NLRP3 inflammasome activation, reducing the levels of activated cysteinyl aspartate-specific proteinase 1 (caspase-1) and mature Interleukin 1beta (IL-1beta). 3-Hydroxybutyric Acid 45-48 NLR family pyrin domain containing 3 Homo sapiens 83-88 30218403-8 2018 Our results suggested that BHB inhibits the activation of NLRP3 inflammasome in C6 glioma cells and consequently suppressed the C6 cell migration. 3-Hydroxybutyric Acid 27-30 NLR family pyrin domain containing 3 Homo sapiens 58-63 30218403-9 2018 These findings also implicated that by inhibiting NLRP3 inflammasome, BHB reduced the inflammatory microenvironment which provided ancillary therapeutic benefits for the intervention of glioma. 3-Hydroxybutyric Acid 70-73 NLR family pyrin domain containing 3 Homo sapiens 50-55 29325899-4 2018 Specifically, beta-hydroxybutyrate has been shown to interact with multiple novel molecular targets such as histone deacetylases, hydroxycarboxylic acid receptors on immune cells, and the NLRP3 inflammasome. 3-Hydroxybutyric Acid 14-34 NLR family pyrin domain containing 3 Homo sapiens 188-193 28836226-4 2017 Recently the ketone body, beta-hydroxy butyrate (BHB), was shown to efficiently inhibit the NLRP3 inflammasome in macrophages, and in vivo models of inflammatory disease. 3-Hydroxybutyric Acid 49-52 NLR family pyrin domain containing 3 Homo sapiens 92-97 28129888-11 2017 Recent preclinical studies have reported that beta-hydroxybutyrate (betaOHB) may protect the brain from the adverse effects of both the nucleotide-binding oligomerization domain (NOD)-like receptor protein 3 (NLRP3) inflammasome and the deacetylation of histone. 3-Hydroxybutyric Acid 46-66 NLR family pyrin domain containing 3 Homo sapiens 209-214 27011059-6 2016 Both IL-1 blockade and two recently identified specific NLRP3 inflammasome blockers, MCC950 and beta-hydroxybutyrate, have shown promise in the treatment of inflammasome-mediated conditions. 3-Hydroxybutyric Acid 96-116 NLR family pyrin domain containing 3 Homo sapiens 56-61 28249154-0 2017 beta-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares. 3-Hydroxybutyric Acid 0-20 NLR family pyrin domain containing 3 Homo sapiens 44-49 28249154-5 2017 BHB inhibited NLRP3 inflammasome in S100A9 fibril-primed and urate crystal-activated macrophages, which serve to recruit inflammatory neutrophils in joints. 3-Hydroxybutyric Acid 0-3 NLR family pyrin domain containing 3 Homo sapiens 14-19 28249154-7 2017 Mechanistically, BHB inhibited the NLRP3 inflammasome in neutrophils by reducing priming and assembly steps. 3-Hydroxybutyric Acid 17-20 NLR family pyrin domain containing 3 Homo sapiens 35-40 25991463-2 2015 Two recent studies identified the sulfonylurea MCC950 and the ketone metabolite beta-hydroxybutyrate as specific inhibitors of the Nlrp3 inflammasome, with promising therapeutic potential for the treatment of auto-inflammatory diseases. 3-Hydroxybutyric Acid 80-100 NLR family pyrin domain containing 3 Homo sapiens 131-136 25686106-0 2015 The ketone metabolite beta-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. 3-Hydroxybutyric Acid 22-42 NLR family pyrin domain containing 3 Homo sapiens 50-55 25686106-4 2015 We report that BHB, but neither AcAc nor the structurally related short-chain fatty acids butyrate and acetate, suppresses activation of the NLRP3 inflammasome in response to urate crystals, ATP and lipotoxic fatty acids. 3-Hydroxybutyric Acid 15-18 NLR family pyrin domain containing 3 Homo sapiens 141-146 25686106-6 2015 Mechanistically, BHB inhibits the NLRP3 inflammasome by preventing K(+) efflux and reducing ASC oligomerization and speck formation. 3-Hydroxybutyric Acid 17-20 NLR family pyrin domain containing 3 Homo sapiens 34-39 25686106-7 2015 The inhibitory effects of BHB on NLRP3 are not dependent on chirality or starvation-regulated mechanisms like AMP-activated protein kinase (AMPK), reactive oxygen species (ROS), autophagy or glycolytic inhibition. 3-Hydroxybutyric Acid 26-29 NLR family pyrin domain containing 3 Homo sapiens 33-38 25686106-8 2015 BHB blocks the NLRP3 inflammasome without undergoing oxidation in the TCA cycle, and independently of uncoupling protein-2 (UCP2), sirtuin-2 (SIRT2), the G protein-coupled receptor GPR109A or hydrocaboxylic acid receptor 2 (HCAR2). 3-Hydroxybutyric Acid 0-3 NLR family pyrin domain containing 3 Homo sapiens 15-20 25686106-9 2015 BHB reduces NLRP3 inflammasome-mediated interleukin (IL)-1beta and IL-18 production in human monocytes. 3-Hydroxybutyric Acid 0-3 NLR family pyrin domain containing 3 Homo sapiens 12-17 25686106-11 2015 Our findings suggest that the anti-inflammatory effects of caloric restriction or ketogenic diets may be linked to BHB-mediated inhibition of the NLRP3 inflammasome. 3-Hydroxybutyric Acid 115-118 NLR family pyrin domain containing 3 Homo sapiens 146-151