PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30784883-2 2019 Herein, a series of N-benzylpiperidine analogs (17-31 and 32-46) were designed and synthesized as multi-functional inhibitors of acetylcholinesterase (AChE) and beta-secretase-1 (BACE-1) with moderate to excellent inhibitory activities. 1-benzylpiperidine 20-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 129-149 31585263-3 2019 Some new inhibitors of AChE combining pyridine, acylhydrazone and N-benzylpiperidine fragments were developed in this work. 1-benzylpiperidine 66-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 31901380-3 2020 Thus, we focused on developing of AChE inhibitors with benzylpiperidine/piperazine moieties that are based on the dantrolene skeleton. 1-benzylpiperidine 55-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 30784883-2 2019 Herein, a series of N-benzylpiperidine analogs (17-31 and 32-46) were designed and synthesized as multi-functional inhibitors of acetylcholinesterase (AChE) and beta-secretase-1 (BACE-1) with moderate to excellent inhibitory activities. 1-benzylpiperidine 20-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 151-155 29421570-2 2018 The molecular hybridization approach was based on the combination, in a single molecule, of the pharmacophoric N-benzyl-piperidine subunit of donepezil, the substituted hydroxy-piperidine fragment of the AChE inhibitor LASSBio-767, and an acylhydrazone linker, a privileged structure present in a number of synthetic aryl- and aryl-acylhydrazone derivatives with significant AChE and anti-inflammatory activities. 1-benzylpiperidine 111-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 204-208 29421570-2 2018 The molecular hybridization approach was based on the combination, in a single molecule, of the pharmacophoric N-benzyl-piperidine subunit of donepezil, the substituted hydroxy-piperidine fragment of the AChE inhibitor LASSBio-767, and an acylhydrazone linker, a privileged structure present in a number of synthetic aryl- and aryl-acylhydrazone derivatives with significant AChE and anti-inflammatory activities. 1-benzylpiperidine 111-130 acetylcholinesterase (Cartwright blood group) Homo sapiens 375-379 28610432-0 2017 QSAR model for prediction of the therapeutic potency of N-benzylpiperidine derivatives as AChE inhibitors. 1-benzylpiperidine 56-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-94 28841514-4 2017 Herein, we report the development of a novel series of thiosemicarbazones derived from 1-benzylpiperidine, a pharmacophore within the acetylcholinesterase inhibitor, Donepezil. 1-benzylpiperidine 87-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 134-154 28610432-1 2017 A new family of AChE inhibitors, N-benzylpiperidines, showed exceptional efficacy in vitro and in vivo, minimal side effects and high selectivity for acetylcholinesterase (AChE). 1-benzylpiperidine 33-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 28610432-1 2017 A new family of AChE inhibitors, N-benzylpiperidines, showed exceptional efficacy in vitro and in vivo, minimal side effects and high selectivity for acetylcholinesterase (AChE). 1-benzylpiperidine 33-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 150-170 28610432-1 2017 A new family of AChE inhibitors, N-benzylpiperidines, showed exceptional efficacy in vitro and in vivo, minimal side effects and high selectivity for acetylcholinesterase (AChE). 1-benzylpiperidine 33-52 acetylcholinesterase (Cartwright blood group) Homo sapiens 172-176 24211638-0 2013 Novel coumarin-3-carboxamides bearing N-benzylpiperidine moiety as potent acetylcholinesterase inhibitors. 1-benzylpiperidine 38-56 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 27914796-3 2017 Two series of unreported N-benzylpiperidines 5(a-h) and thiazolopyrimidines 9(a-q) molecules were synthesized and evaluated in vitro for their acetylcholinesterase (AChE) inhibitory activities. 1-benzylpiperidine 25-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-163 27914796-3 2017 Two series of unreported N-benzylpiperidines 5(a-h) and thiazolopyrimidines 9(a-q) molecules were synthesized and evaluated in vitro for their acetylcholinesterase (AChE) inhibitory activities. 1-benzylpiperidine 25-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 165-169 27402296-2 2016 RESULTS: By combining the lipoic acid structure with N-benzylpiperidine or N,N-dibenzyl(N-methyl)amine fragments, new multi-target directed ligands were obtained that act at three relevant targets in AD: sigma-1 receptor (sigma1R), beta-secretase-1 (BACE1) and acetylcholinesterase (AChE). 1-benzylpiperidine 53-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 261-281 27402296-2 2016 RESULTS: By combining the lipoic acid structure with N-benzylpiperidine or N,N-dibenzyl(N-methyl)amine fragments, new multi-target directed ligands were obtained that act at three relevant targets in AD: sigma-1 receptor (sigma1R), beta-secretase-1 (BACE1) and acetylcholinesterase (AChE). 1-benzylpiperidine 53-71 acetylcholinesterase (Cartwright blood group) Homo sapiens 283-287 24211638-1 2013 Some novel coumarin-3-carboxamide derivatives linked to N-benzylpiperidine scaffold were synthesized and evaluated as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors. 1-benzylpiperidine 56-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 118-138 24211638-1 2013 Some novel coumarin-3-carboxamide derivatives linked to N-benzylpiperidine scaffold were synthesized and evaluated as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors. 1-benzylpiperidine 56-74 acetylcholinesterase (Cartwright blood group) Homo sapiens 140-144 10067428-7 1999 We replaced the N-benzylpiperazine moiety with N-benzylpiperidine moiety and found a dramatic increase in anti-AChE activity. 1-benzylpiperidine 47-65 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-115 21074294-0 2011 Receptor-dependent (RD) 3D-QSAR approach of a series of benzylpiperidine inhibitors of human acetylcholinesterase (HuAChE). 1-benzylpiperidine 56-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-113 21074294-2 2011 In this work, we developed a receptor-dependent 3D-QSAR (RD-3D-QSAR) models based on a series of 60 benzylpiperidine inhibitors of human acetylcholinesterase to support the design of new AChEIs. 1-benzylpiperidine 100-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 137-157 11256231-5 2000 The benzylpiperidine derivatives donepezil and TAK-147 showed high selectivity for AChE over BuChE. 1-benzylpiperidine 4-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-87 10733609-2 2000 3D quantitative structure-activity relationship (3D QSAR) models have been derived for a series of N-benzylpiperidine derivatives which are potent acetylcholinesterase (AChE) inhibitors interesting for Alzheimer"s disease. 1-benzylpiperidine 99-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-167 10733609-2 2000 3D quantitative structure-activity relationship (3D QSAR) models have been derived for a series of N-benzylpiperidine derivatives which are potent acetylcholinesterase (AChE) inhibitors interesting for Alzheimer"s disease. 1-benzylpiperidine 99-117 acetylcholinesterase (Cartwright blood group) Homo sapiens 169-173 15892689-1 2005 The Electronic-Topological (ETM) and Neural Network methods were applied to the study of the "structure-acetylcholinesterase (AChE) inhibitor activity" relationships for a series of physostigmine and N-benzylpiperidine derivatives. 1-benzylpiperidine 200-218 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-124 15892689-1 2005 The Electronic-Topological (ETM) and Neural Network methods were applied to the study of the "structure-acetylcholinesterase (AChE) inhibitor activity" relationships for a series of physostigmine and N-benzylpiperidine derivatives. 1-benzylpiperidine 200-218 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 8558505-0 1996 A comparative molecular field analysis study of N-benzylpiperidines as acetylcholinesterase inhibitors. 1-benzylpiperidine 48-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 8894101-3 1996 A combination of molecular modeling and QSAR studies have been used throughout the evolution of the AChE inhibitor program leading to the benzylpiperidine series, and, ultimately, E2020. 1-benzylpiperidine 138-154 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-104 34327619-1 2021 Multi-target directed ligand-based 2D-QSAR models were developed using different N-benzyl piperidine derivatives showing inhibitory activity toward acetylcholinesterase (AChE) and beta-Site amyloid precursor protein cleaving enzyme (BACE1). 1-benzylpiperidine 81-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 148-168 34327619-1 2021 Multi-target directed ligand-based 2D-QSAR models were developed using different N-benzyl piperidine derivatives showing inhibitory activity toward acetylcholinesterase (AChE) and beta-Site amyloid precursor protein cleaving enzyme (BACE1). 1-benzylpiperidine 81-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 35462163-4 2022 In silico studies confirmed the interaction of benzylpiperidine and the benzylpiperazine isostere with the catalytic anionic site (CAS) of AChE, while the aryloxycarbonyl portion appeared to be important for the interaction with the peripheral site (PAS). 1-benzylpiperidine 47-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 139-143 1738152-6 1992 However, the crystal conformations and the postulated active conformation of the benzylpiperidine portion of the AChE inhibitor are estimated to be about equally stable. 1-benzylpiperidine 81-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 1738151-0 1992 QSAR analyses of the substituted indanone and benzylpiperidine rings of a series of indanone-benzylpiperidine inhibitors of acetylcholinesterase. 1-benzylpiperidine 46-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-144 1738151-1 1992 QSAR analyses have been performed on the substituted indanone and benzylpiperidine ring substructures of a set of acetylcholinesterase, AChE, inhibitors of which 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride is a potent in vitro and ex vivo inhibitor. 1-benzylpiperidine 66-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 114-134 1738151-1 1992 QSAR analyses have been performed on the substituted indanone and benzylpiperidine ring substructures of a set of acetylcholinesterase, AChE, inhibitors of which 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride is a potent in vitro and ex vivo inhibitor. 1-benzylpiperidine 66-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 136-140