PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11325345-1 2001 A transgenic mouse expressing the human beta-amyloid precursor protein with the "Swedish" mutation, Tg2576, was used to investigate the mechanism of beta-amyloid (Abeta) deposition. tg2576 100-106 amyloid beta precursor protein Homo sapiens 40-70 16828889-3 2006 Aged F-344 rats and young mice over-expressing the Swedish mutation in the human amyloid precursor protein (APPsw; Tg2576+) had elevated levels of soluble Abeta, and were more vulnerable to scopolamine challenge in the Morris water maze (MWM), relative to young rats and Tg2576- mice; but, among individual animals, higher levels of soluble Abeta were not correlated with vulnerability to scopolamine. tg2576 115-121 amyloid beta precursor protein Homo sapiens 81-106 16828889-3 2006 Aged F-344 rats and young mice over-expressing the Swedish mutation in the human amyloid precursor protein (APPsw; Tg2576+) had elevated levels of soluble Abeta, and were more vulnerable to scopolamine challenge in the Morris water maze (MWM), relative to young rats and Tg2576- mice; but, among individual animals, higher levels of soluble Abeta were not correlated with vulnerability to scopolamine. tg2576 115-121 amyloid beta precursor protein Homo sapiens 155-160 21556141-8 2011 Furthermore, blocking K(+) efflux protected Tg2576 neurons from Abeta-induced neurotoxicity. tg2576 44-50 amyloid beta precursor protein Homo sapiens 64-69 15653168-6 2005 Peripheral administration of these vaccines augmented humoral responses to Abeta and reduced CNS Abeta deposition in Tg2576 AD mice. tg2576 117-123 amyloid beta precursor protein Homo sapiens 97-102 29997495-8 2018 We extended this line of research to in vivo studies using transgenic human amyloid precursor protein (hAPP)-overexpressing mice (Tg2576) that were treated with PYR41, a cell-permeable, irreversible inhibitor of the ubiquitin-activating enzyme E1. tg2576 130-136 amyloid beta precursor protein Homo sapiens 103-107 11377835-1 2001 A transgenic mouse expressing the human beta-amyloid precursor protein with the "Swedish" mutation, Tg2576, was used to investigate the mechanism of amyloid-beta peptide (Abeta) deposition. tg2576 100-106 amyloid beta precursor protein Homo sapiens 40-70