PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8495097-3	1993	Following trimethoprim-sulfamethoxazole therapy, he was free from the above infections, and impaired polymorphonuclear leukocyte functions recovered and serum IgE decreased to approximately one-fifth of its initial level.	Trimethoprim, Sulfamethoxazole Drug Combination	10-39	immunoglobulin heavy constant epsilon	Homo sapiens	159-162	
3237218-1	1988	An immunoassay was developed for the detection of sulfamethoxazole reactive IgE antibodies in the sera of patients who experienced life threatening anaphylactic reactions following the ingestion of co-trimoxazole (trimethoprim and sulfamethoxazole).	Trimethoprim, Sulfamethoxazole Drug Combination	198-212	immunoglobulin heavy constant epsilon	Homo sapiens	76-79	
3237218-5	1988	The assays for the detection of IgE antibodies to sulfamethoxazole and trimethoprim should prove useful for the diagnosis of immediate hypersensitivity to co-trimoxazole and perhaps for monitoring drug therapy in AIDS patients where a high incidence of adverse reactions to co-trimoxazole has been reported.	Trimethoprim, Sulfamethoxazole Drug Combination	155-169	immunoglobulin heavy constant epsilon	Homo sapiens	32-35	
3237218-5	1988	The assays for the detection of IgE antibodies to sulfamethoxazole and trimethoprim should prove useful for the diagnosis of immediate hypersensitivity to co-trimoxazole and perhaps for monitoring drug therapy in AIDS patients where a high incidence of adverse reactions to co-trimoxazole has been reported.	Trimethoprim, Sulfamethoxazole Drug Combination	274-288	immunoglobulin heavy constant epsilon	Homo sapiens	32-35	
8724071-5	1996	CONCLUSIONS: We conclude that a rapid, oral trimethoprim-sulfamethoxazole desensitization protocol is safe and, in some instances, effective among HIV-infected children and infants with a history of non-life-threatening, IgE-mediated reactions to trimethoprim-sulfamethoxazole.	Trimethoprim, Sulfamethoxazole Drug Combination	44-73	immunoglobulin heavy constant epsilon	Homo sapiens	221-224	
8495097-4	1993	Subsequent irregular medications, however, resulted in impairment of polymorphonuclear leukocyte functions and an increased serum IgE concentration, which recovered after regular resumption of trimethoprim-sulfamethoxazole treatment.	Trimethoprim, Sulfamethoxazole Drug Combination	193-222	immunoglobulin heavy constant epsilon	Homo sapiens	130-133