PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10432069-0 1999 Plasmodium falciparum: selection of serine 108 of dihydrofolate reductase during treatment of uncomplicated malaria with co-trimoxazole in Ugandan children. Trimethoprim, Sulfamethoxazole Drug Combination 121-135 dihydrofolate reductase Homo sapiens 50-73 12018659-7 2002 The two patients whose isolates showed non-synonymous DHFR mutations were not exposed to DHFR inhibitors before they developed PCP and were treated successfully with co-trimoxazole. Trimethoprim, Sulfamethoxazole Drug Combination 166-180 dihydrofolate reductase Homo sapiens 54-58 16014854-0 2005 Response of Plasmodium falciparum to cotrimoxazole therapy: relationship with plasma drug concentrations and dihydrofolate reductase and dihydropteroate synthase genotypes. Trimethoprim, Sulfamethoxazole Drug Combination 37-50 dihydrofolate reductase Homo sapiens 109-132 16014854-1 2005 We assessed the efficacy of trimethoprim/sulfamethoxazole (TRM/SMX) in vivo in relation to the frequency of dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) alleles in 45 Sudanese malaria patients. Trimethoprim, Sulfamethoxazole Drug Combination 28-57 dihydrofolate reductase Homo sapiens 108-131 16014854-1 2005 We assessed the efficacy of trimethoprim/sulfamethoxazole (TRM/SMX) in vivo in relation to the frequency of dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) alleles in 45 Sudanese malaria patients. Trimethoprim, Sulfamethoxazole Drug Combination 28-57 dihydrofolate reductase Homo sapiens 133-137 16014854-1 2005 We assessed the efficacy of trimethoprim/sulfamethoxazole (TRM/SMX) in vivo in relation to the frequency of dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) alleles in 45 Sudanese malaria patients. Trimethoprim, Sulfamethoxazole Drug Combination 59-66 dihydrofolate reductase Homo sapiens 108-131 16014854-1 2005 We assessed the efficacy of trimethoprim/sulfamethoxazole (TRM/SMX) in vivo in relation to the frequency of dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) alleles in 45 Sudanese malaria patients. Trimethoprim, Sulfamethoxazole Drug Combination 59-66 dihydrofolate reductase Homo sapiens 133-137 16014854-8 2005 However, the presence of the triple mutant dhfr (Ile-51/Arg-59/Asn-108) with the dhps Gly-437 genotype in all recurring infections, suggests the importance of codon 59 and 437 alleles in susceptibility to TRM/SMX. Trimethoprim, Sulfamethoxazole Drug Combination 205-212 dihydrofolate reductase Homo sapiens 43-47 10432069-2 1999 Selection towards a specific genotype at some codons of the DHFR and DHPS genes was observed in samples collected after exposure to co-trimoxazole drug pressure. Trimethoprim, Sulfamethoxazole Drug Combination 132-146 dihydrofolate reductase Homo sapiens 60-64 33002448-10 2020 The high prevalence of quadruple dhps/dhfr mutants indicates strong antifolate drug pressure from SP or other drugs (e.g., co-trimoxazole). Trimethoprim, Sulfamethoxazole Drug Combination 123-137 dihydrofolate reductase Homo sapiens 38-42 27647575-12 2016 Most likely, the sustained high prevalence of resistant parasites is due to the use of DHFR/DHPS inhibitors like trimethoprim-sulfamethoxazole (TS) for the treatment of and prophylaxis against bacterial infections among HIV infected individuals as well as the continued use of IPTp-SP within the East and Central African regions for malaria prevention among pregnant women. Trimethoprim, Sulfamethoxazole Drug Combination 113-142 dihydrofolate reductase Homo sapiens 87-91 27647575-12 2016 Most likely, the sustained high prevalence of resistant parasites is due to the use of DHFR/DHPS inhibitors like trimethoprim-sulfamethoxazole (TS) for the treatment of and prophylaxis against bacterial infections among HIV infected individuals as well as the continued use of IPTp-SP within the East and Central African regions for malaria prevention among pregnant women. Trimethoprim, Sulfamethoxazole Drug Combination 144-146 dihydrofolate reductase Homo sapiens 87-91