PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23153588-0 2013 Cyclosporine A and PSC833 inhibit ABCA1 function via direct binding. valspodar 19-25 phospholipid-transporting ATPase ABCA1 Mesocricetus auratus 34-39 23153588-9 2013 Furthermore, a non-immunosuppressive cyclosporine, PSC833, inhibited ABCA1-mediated cholesterol efflux with IC(50) of 1.9muM, and efficiently competed with [(3)H] cyclosporine A binding to ABCA1. valspodar 51-57 phospholipid-transporting ATPase ABCA1 Mesocricetus auratus 69-74 23153588-9 2013 Furthermore, a non-immunosuppressive cyclosporine, PSC833, inhibited ABCA1-mediated cholesterol efflux with IC(50) of 1.9muM, and efficiently competed with [(3)H] cyclosporine A binding to ABCA1. valspodar 51-57 phospholipid-transporting ATPase ABCA1 Mesocricetus auratus 189-194 23153588-10 2013 These results indicate that cyclosporine A and PSC833 inhibit ABCA1 via direct binding, and that the ABCA1 inhibitor PSC833 is an excellent candidate for further investigations of the detailed mechanisms underlying formation of HDL. valspodar 47-53 phospholipid-transporting ATPase ABCA1 Mesocricetus auratus 62-67