PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35194640-6	2022	In macrophages/goblet-like LS174T cells co-culture systems, butyrate-primed M2 macrophages significantly enhanced the expression of mucin-2 (MUC2) and SPDEF (goblet cell marker genes) than butyrate alone, while blockade of WNTs secretion or ERK1/2 activation significantly decreased the beneficial effect of butyrate-primed macrophages on goblet cell function.	Butyrates	60-68	mitogen-activated protein kinase 3	Homo sapiens	241-247	
11535873-3	2001	Moreover, butyrate and propionate specifically resulted in a decrease in ERK1 and 2 phosphorylation at 3 and 6 hours post-treatment, suggesting a correlation between the ability of these SCFAs to inhibit cellular proliferation and decrease ERK phosphorylation.	Butyrates	10-18	mitogen-activated protein kinase 3	Homo sapiens	73-83	
12094619-8	2001	Butyrate also induced the phosphorylation of extracellular signal-regulated kinases (ERK1/2, Western blotting) after 5-30 min, which indicates a regulation of GST expression by this signal pathway.	Butyrates	0-8	mitogen-activated protein kinase 3	Homo sapiens	85-91	
28045428-8	2017	Furthermore, butyrate treatment increased the phosphorylation of extracellular-regulated kinase 1/2 (p-ERK1/2), a survival signal, in NCM460 cells while it decreased p-ERK1/2 in HCT116 cells.	Butyrates	13-21	mitogen-activated protein kinase 3	Homo sapiens	168-174	
35154692-9	2022	Therefore, our results showed that acetate, propionate, and butyrate ameliorated the fetal small intestine inflammatory response induced by IL-1beta through inhibiting ERK1/2 pathway; NF-kappaB p65, JNK1/2, and ERK1/2 pathways; or NF-kappaB p65 and ERK1/2 pathways, respectively.	Butyrates	60-68	mitogen-activated protein kinase 3	Homo sapiens	168-174	
35154692-9	2022	Therefore, our results showed that acetate, propionate, and butyrate ameliorated the fetal small intestine inflammatory response induced by IL-1beta through inhibiting ERK1/2 pathway; NF-kappaB p65, JNK1/2, and ERK1/2 pathways; or NF-kappaB p65 and ERK1/2 pathways, respectively.	Butyrates	60-68	mitogen-activated protein kinase 3	Homo sapiens	211-217	
35154692-9	2022	Therefore, our results showed that acetate, propionate, and butyrate ameliorated the fetal small intestine inflammatory response induced by IL-1beta through inhibiting ERK1/2 pathway; NF-kappaB p65, JNK1/2, and ERK1/2 pathways; or NF-kappaB p65 and ERK1/2 pathways, respectively.	Butyrates	60-68	mitogen-activated protein kinase 3	Homo sapiens	249-255	
29702431-8	2018	Ip injection of butyrate induced significant phosphorylation of extracellular-signal-regulated kinase 1/2, cellular activation markers, in nodose ganglia and their projection site, medial nucleus tractus solitaries.	Butyrates	16-24	mitogen-activated protein kinase 3	Homo sapiens	64-105	
27293079-9	2017	Instead, BAY completely abolishes butyrate-induced differentiation and apoptosis in a Syk- and ERK1/2-dependent manner.	Butyrates	34-42	mitogen-activated protein kinase 3	Homo sapiens	95-101	
27293079-10	2017	While butyrate dephosphorylates ERK1/2 in HT-29 cells, BAY re-phosphorylates it, leading to its activation.	Butyrates	6-14	mitogen-activated protein kinase 3	Homo sapiens	32-38	
29233468-4	2017	By using wound healing and transwell-based invasion models, we demonstrated that pretreatment of butyrate significantly inhibited motility of HCT116, HT29, LOVO and HCT8 cells, this activity was further attributed to deactivation of Akt1 and ERK1/2.	Butyrates	97-105	mitogen-activated protein kinase 3	Homo sapiens	242-248	
28045428-8	2017	Furthermore, butyrate treatment increased the phosphorylation of extracellular-regulated kinase 1/2 (p-ERK1/2), a survival signal, in NCM460 cells while it decreased p-ERK1/2 in HCT116 cells.	Butyrates	13-21	mitogen-activated protein kinase 3	Homo sapiens	103-109	
24533426-1	2013	The role of crosstalk between the Smad and the MAPK signaling pathways in activin-, transforming growth factor-beta (TGF-beta)-, hydroxyurea (HU) - and butyrate-dependent erythroid differentiation of K562 leukemic cells was studied.	Butyrates	152-160	mitogen-activated protein kinase 3	Homo sapiens	47-51	
22247602-12	2012	In conclusions, butyrate enhances interleukin-1beta production by activating caspase-1, via reactive oxygen species, the phosphorylation of MAPK, and G protein mediated pathways in lipopolysaccharide stimulated THP-1 cells.	Butyrates	16-24	mitogen-activated protein kinase 3	Homo sapiens	140-144	
23300800-8	2012	Moreover, butyrate enhanced the PMA-induced expression of c-fos and ERK1/2 phosphorylation, but not p38 and JNK.	Butyrates	10-18	mitogen-activated protein kinase 3	Homo sapiens	68-74	
17055059-7	2007	Co-incubation of butyrate with a VDR, p38 MAPK, ERK 1/2 and TGF-beta1 receptor kinase inhibitor all reduced butyrate-mediated LL-37 mRNA up-regulation.	Butyrates	17-25	mitogen-activated protein kinase 3	Homo sapiens	48-55	
17055059-7	2007	Co-incubation of butyrate with a VDR, p38 MAPK, ERK 1/2 and TGF-beta1 receptor kinase inhibitor all reduced butyrate-mediated LL-37 mRNA up-regulation.	Butyrates	108-116	mitogen-activated protein kinase 3	Homo sapiens	48-55	
21475856-6	2009	Although butyrate did not alter ErbB protein expression and activation, it did block the prolonged activation of Akt and Erk1/2, which are known to be important ErbB downstream molecules mediating heregulin-stimulated proliferation.	Butyrates	9-17	mitogen-activated protein kinase 3	Homo sapiens	121-127