PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31089436-6	2019	Butyrate and propionate inhibited Sa.LPP-induced expression of inducible NO synthase (iNOS).	Butyrates	0-8	nitric oxide synthase 2, inducible	Mus musculus	63-84	
33875384-10	2021	This was accompanied by an amplification of iNOS-inducing cytokines, interferon gamma and tumor necrosis factor alpha in the ASC-splenocyte co-culture, triggering ASCs to produce high NO levels under the influence of BA.	Butyrates	217-219	nitric oxide synthase 2, inducible	Mus musculus	44-48	
31089436-8	2019	Furthermore, butyrate and propionate, but not acetate, inhibited Sa.LPP-induced activation of NF-kappaB, expression of IFN-beta, and phosphorylation of STAT1, which are essential for inducing transcription of iNOS in macrophages.	Butyrates	13-21	nitric oxide synthase 2, inducible	Mus musculus	209-213	
31089436-6	2019	Butyrate and propionate inhibited Sa.LPP-induced expression of inducible NO synthase (iNOS).	Butyrates	0-8	nitric oxide synthase 2, inducible	Mus musculus	86-90	
27261536-10	2016	The reduction of oxidative stress related to NADPH oxidase and iNOS expression levels associated to butyrate supplementation attenuates endothelium dysfunction and macrophage migration and activation in the lesion site.	Butyrates	100-108	nitric oxide synthase 2, inducible	Mus musculus	63-67	
30448827-6	2018	RESULTS: Butyrate reduced the expression of canonic pro-inflammatory mediators (Nos2, COX-2, IL-6), pro-inflammatory adipokines (lipocalin-2 and nesfatin-1) and adhesion molecule (VCAM-1 and ICAM-1) in IL-1beta-stimulated chondrocytes, inhibiting several inflammatory signalling pathways (NFkappaB, MAPKinase, AMPK-alpha, PI3K/Akt).	Butyrates	9-17	nitric oxide synthase 2, inducible	Mus musculus	80-84	
26675718-7	2016	Western blot analysis, confirmed the role of peroxisome receptors in butyrate effects, evidencing the increase of PPAR-alpha and -gamma expression, associated to the reduction of inflammatory markers (COX-2, iNOS, TNF-alpha and cFOS).	Butyrates	69-77	nitric oxide synthase 2, inducible	Mus musculus	208-212	
22517765-7	2012	Knocking down gpr109a or slc5a8, the genes that encode for receptor and transporter of butyrate, respectively, resulted in altered expression of genes related to multiple inflammatory signaling pathways, including inducible nitric oxide synthase (iNOS), in mouse colonic epithelial cells in vivo.	Butyrates	87-95	nitric oxide synthase 2, inducible	Mus musculus	214-245	
22669487-4	2012	The results show that three types of SCFAs (acetate, propionate, and butyrate) reduced the production of proinflammatory factors, including TNF-alpha, IL-1beta, IL-6, and NO, and inhibited the vitality of iNOS.	Butyrates	69-77	nitric oxide synthase 2, inducible	Mus musculus	205-209	
22517765-7	2012	Knocking down gpr109a or slc5a8, the genes that encode for receptor and transporter of butyrate, respectively, resulted in altered expression of genes related to multiple inflammatory signaling pathways, including inducible nitric oxide synthase (iNOS), in mouse colonic epithelial cells in vivo.	Butyrates	87-95	nitric oxide synthase 2, inducible	Mus musculus	247-251	
11052179-4	2000	Butyrate also inhibited the expression of inducible type NO synthase (iNOS) in LPS-stimulated RAW cells.	Butyrates	0-8	nitric oxide synthase 2, inducible	Mus musculus	70-74	
15025822-5	2004	Butyrate enhanced the expression of inducible type NO synthase (iNOS) in the stimulated END-D cells.	Butyrates	0-8	nitric oxide synthase 2, inducible	Mus musculus	64-68	
11052179-7	2000	It was, therefore, suggested that butyrate down-regulated LPS-induced NO production in RAW cells through preventing the expression of iNOS, and that it was due to the inhibitory action of butyrate on the activation of NF-kappaB.	Butyrates	34-42	nitric oxide synthase 2, inducible	Mus musculus	134-138