PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35095533-2	2021	Dimethyl itaconate (DI) has been reported to be efficacious in colorectal cancer by decreasing IL-1beta release from intestinal epithelial cells.	dimethyl itaconate	0-18	interleukin 1 alpha	Homo sapiens	95-103	
35137954-5	2022	DMI, 4OI, DMF and monomethyl fumarate (MMF), another fumarate derivative, also directly inhibited biochemical markers of NLRP3 activation in LPS-primed macrophages, mixed glia, OHSCs and human macrophages in response to nigericin and imiquimod, including ASC speck formation, caspase-1 activation, gasdermin D cleavage and IL-1beta release.	dimethyl itaconate	0-3	interleukin 1 alpha	Homo sapiens	323-331	
34876290-9	2022	Dimethyl itaconate upregulated IL-1beta at 24 hours (FC 18.00 at D4, P <= .001).	dimethyl itaconate	0-18	interleukin 1 alpha	Homo sapiens	31-39	
35137954-2	2022	Derivatives of the metabolites itaconate and fumarate, dimethyl itaconate (DMI), 4-octyl itaconate (4OI) and dimethyl fumarate (DMF), limit both expression and release of IL-1beta following NLRP3 inflammasome activation.	dimethyl itaconate	55-73	interleukin 1 alpha	Homo sapiens	171-179	
35137954-2	2022	Derivatives of the metabolites itaconate and fumarate, dimethyl itaconate (DMI), 4-octyl itaconate (4OI) and dimethyl fumarate (DMF), limit both expression and release of IL-1beta following NLRP3 inflammasome activation.	dimethyl itaconate	75-78	interleukin 1 alpha	Homo sapiens	171-179	
35095533-2	2021	Dimethyl itaconate (DI) has been reported to be efficacious in colorectal cancer by decreasing IL-1beta release from intestinal epithelial cells.	dimethyl itaconate	20-22	interleukin 1 alpha	Homo sapiens	95-103	
32694786-7	2020	This correlates with their immunosuppressive phenotype: dimethyl itaconate and 4-octyl itaconate inhibited IkappaBzeta and pro-interleukin (IL)-1beta induction, as well as IL-6, IL-10 and interferon-beta secretion, in an NRF2-independent manner.	dimethyl itaconate	56-74	interleukin 1 alpha	Homo sapiens	123-149