PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23313808-3 2013 METHODS: Two MPO oxidation products, 3-chlorotyrosine and 3-nitrotyrosine, were quantified by tandem mass spectrometry (MS/MS) in in vitro model system studies and in plasma and HDL derived from healthy controls and RA subjects. 3-chlorotyrosine 37-53 myeloperoxidase Homo sapiens 13-16 25528002-1 2015 BACKGROUND: It is demonstrated that levels of protein-bound chlorotyrosine, nitrotyrosine and myeloperoxidase (MPO), a protein that catalyzes generation of chlorinating and nitrating oxidants, serve as independent predictors of cardiovascular disease. 3-chlorotyrosine 60-74 myeloperoxidase Homo sapiens 111-114 29505607-7 2018 HDL of CAD subjects had significantly higher 3-nitrotyrosine than non-CAD subjects, but the MPO-specific 3-chlorotyrosine was unchanged; CEC in the CAD low-HDL group did not correlate with either HDL 3-chlorotyrosine or 3-nitrotyrosine levels. 3-chlorotyrosine 105-121 myeloperoxidase Homo sapiens 92-95 23313808-7 2013 There was marked increase in MPO-specific 3-chlorotyrosine and 3-nitrotyrosine content in HDL in RA subjects consistent with specific targeting of HDL, with increased nitration in RA subjects with CVD. 3-chlorotyrosine 42-58 myeloperoxidase Homo sapiens 29-32 22462773-4 2012 Strikingly, the presence of physiologic concentrations of SCN completely prevented MPO-induced 3-chlorotyrosine formation in HDL. 3-chlorotyrosine 95-111 myeloperoxidase Homo sapiens 83-86 23493288-7 2013 We observed that the SR-BI inhibitory activity of albumin isolated from chronic kidney disease patients correlated with the content of the myeloperoxidase-specific oxidation product 3-chlorotyrosine and was associated with alterations in the composition of high-density lipoprotein. 3-chlorotyrosine 182-198 myeloperoxidase Homo sapiens 139-154 22967600-4 2012 Protein damages due to MPO activity have never been assessed during hemodialysis although two of its reaction products, 3-chlorotyrosine and homocitrulline, are of interest. 3-chlorotyrosine 120-136 myeloperoxidase Homo sapiens 23-26 22814531-10 2012 3-Chlorotyrosine, a specific biomarker of hypochlorous acid, was present in proteins from SF and related to the concentration of MPO (r=0.69; P=0.001). 3-chlorotyrosine 0-16 myeloperoxidase Homo sapiens 129-132 22967600-9 2012 Both increases in MPO activity and protein-bound 3-chlorotyrosine were observed, highlighting the involvement of MPO in oxidative stress during hemodialysis and further demonstrating the link between hemodialysis and cardiovascular diseases. 3-chlorotyrosine 49-65 myeloperoxidase Homo sapiens 113-116 22178192-3 2012 Mass spectrometric analysis demonstrated that levels of 3-chlorotyrosine and 3-nitrotyrosine - two characteristic products of MPO - are elevated in HDL isolated from patients with established cardiovascular disease. 3-chlorotyrosine 56-72 myeloperoxidase Homo sapiens 126-129 21235354-5 2011 The carbamyllysine content of lesion-derived HDL was more than 20-fold higher in comparison with 3-chlorotyrosine levels, a specific oxidation product of MPO. 3-chlorotyrosine 97-113 myeloperoxidase Homo sapiens 154-157 21501700-4 2011 Levels of two characteristic products of MPO-chlorotyrosine and nitrotyrosine-are markedly elevated in HDL from human atherosclerotic lesions. 3-chlorotyrosine 45-59 myeloperoxidase Homo sapiens 41-44 21235354-7 2011 The carbamyllysine content of HDL, but not of LDL, correlated with levels of 3-chlorotyrosine, suggesting that MPO mediated carbamylation in the vessel wall. 3-chlorotyrosine 77-93 myeloperoxidase Homo sapiens 111-114 21319831-4 2011 The preferred biomarker for HOCl, and by extension its synthesizing enzyme myeloperoxidase, is 3-chlorotyrosine. 3-chlorotyrosine 95-111 myeloperoxidase Homo sapiens 75-90 20043647-5 2010 We used mass spectrometry to demonstrate that HDL isolated from patients with established cardiovascular disease contains elevated levels of 3-chlorotyrosine and 3-nitrotyrosine, two characteristic products of MPO. 3-chlorotyrosine 141-157 myeloperoxidase Homo sapiens 210-213 21166629-10 2010 The sputum levels of 3Cl-Tyr correlated well with sputum MPO activity (r = 0.88; p < 0.0001). 3-chlorotyrosine 21-28 myeloperoxidase Homo sapiens 57-60 21166629-11 2010 The presence of 3Cl-Tyr in the sputum of stable COPD patients suggests an active process related to MPO that may play a role in the pathophysiology of this disease. 3-chlorotyrosine 16-23 myeloperoxidase Homo sapiens 100-103 20064972-4 2010 HDL isolated from human atherosclerotic lesions and blood of subjects with established coronary artery disease contains elevated levels of 3-chlorotyrosine and 3-nitrotyrosine, two characteristic products of myeloperoxidase (MPO), a heme protein secreted by macrophages. 3-chlorotyrosine 139-155 myeloperoxidase Homo sapiens 208-223 20064972-4 2010 HDL isolated from human atherosclerotic lesions and blood of subjects with established coronary artery disease contains elevated levels of 3-chlorotyrosine and 3-nitrotyrosine, two characteristic products of myeloperoxidase (MPO), a heme protein secreted by macrophages. 3-chlorotyrosine 139-155 myeloperoxidase Homo sapiens 225-228 19273198-4 2009 In particular, among peroxidases, myeloperoxidase is recognized as a key enzyme, capable of impairing intracellular NO reservoirs as well as producing oxidized amino acids such as 3-chlorotyrosine or 3-nitrotyrosine. 3-chlorotyrosine 180-196 myeloperoxidase Homo sapiens 34-49 20332596-6 2010 In addition, 3-chlorotyrosine (a specific marker of MPO activity) was searched for using liquid mass chromatography both in TEN and burn blister fluids. 3-chlorotyrosine 13-29 myeloperoxidase Homo sapiens 52-55 19030913-7 2009 Moreover, 3-chlorotyrosine accumulation in treated cells alone indicated the presence of MPO-derived hypochlorous acid. 3-chlorotyrosine 10-26 myeloperoxidase Homo sapiens 89-92 16774039-4 2006 Recent MS studies indicate that HDL isolated from patients with cardiovascular disease contains elevated levels of 3-chlorotyrosine and 3-nitrotyrosine, which are two characteristic products of myeloperoxidase (MPO), a heme enzyme secreted by macrophages. 3-chlorotyrosine 115-131 myeloperoxidase Homo sapiens 194-209 18405660-2 2008 A proposed bio-marker for MPO-derived HOCl in vivo is 3-chlorotyrosine, elevated levels of which have been measured in several human inflammatory pathologies. 3-chlorotyrosine 54-70 myeloperoxidase Homo sapiens 26-29 18314009-6 2008 Plasma levels of 3-Cl-Tyr, a product of MPO, were analyzed by HPLC coupled with Coularray electrochemical detection. 3-chlorotyrosine 17-25 myeloperoxidase Homo sapiens 40-43 18314009-9 2008 Plasma MPO was correlated with 3-Cl-Tyr (r=0.389, p<0.01) and WBC counts (r=0.405, p<0.01) respectively. 3-chlorotyrosine 31-39 myeloperoxidase Homo sapiens 7-10 16774039-4 2006 Recent MS studies indicate that HDL isolated from patients with cardiovascular disease contains elevated levels of 3-chlorotyrosine and 3-nitrotyrosine, which are two characteristic products of myeloperoxidase (MPO), a heme enzyme secreted by macrophages. 3-chlorotyrosine 115-131 myeloperoxidase Homo sapiens 211-214 15607739-4 2005 Recently 3-chlorotyrosine, a bio-marker for MPO activity (and HOCl production), was shown to be elevated threefold in hippocampal proteins from AD patients. 3-chlorotyrosine 9-25 myeloperoxidase Homo sapiens 44-47 16497665-2 2006 Myeloperoxidase (MPO) is the only known source of 3-chlorotyrosine in vivo, indicating that MPO oxidizes HDL in humans. 3-chlorotyrosine 50-66 myeloperoxidase Homo sapiens 0-15 16497665-2 2006 Myeloperoxidase (MPO) is the only known source of 3-chlorotyrosine in vivo, indicating that MPO oxidizes HDL in humans. 3-chlorotyrosine 50-66 myeloperoxidase Homo sapiens 17-20 16497665-2 2006 Myeloperoxidase (MPO) is the only known source of 3-chlorotyrosine in vivo, indicating that MPO oxidizes HDL in humans. 3-chlorotyrosine 50-66 myeloperoxidase Homo sapiens 92-95 16871943-2 2006 The posttranslational modifications, 3-bromo-tyrosine (Br-Tyr) and 3-chloro-tyrosine (Cl-Tyr), serve as specific molecular markers for production of brominating and chlorinating oxidants, respectively, by the eosinophil peroxidase and myeloperoxidase systems of leukocytes. 3-chlorotyrosine 67-84 myeloperoxidase Homo sapiens 235-250 16871943-2 2006 The posttranslational modifications, 3-bromo-tyrosine (Br-Tyr) and 3-chloro-tyrosine (Cl-Tyr), serve as specific molecular markers for production of brominating and chlorinating oxidants, respectively, by the eosinophil peroxidase and myeloperoxidase systems of leukocytes. 3-chlorotyrosine 86-92 myeloperoxidase Homo sapiens 235-250 15574409-2 2005 Myeloperoxidase (MPO) is the only known source of 3-chlorotyrosine in humans, indicating that MPO oxidizes HDL in vivo. 3-chlorotyrosine 50-66 myeloperoxidase Homo sapiens 0-15 15574409-2 2005 Myeloperoxidase (MPO) is the only known source of 3-chlorotyrosine in humans, indicating that MPO oxidizes HDL in vivo. 3-chlorotyrosine 50-66 myeloperoxidase Homo sapiens 17-20 15574409-2 2005 Myeloperoxidase (MPO) is the only known source of 3-chlorotyrosine in humans, indicating that MPO oxidizes HDL in vivo. 3-chlorotyrosine 50-66 myeloperoxidase Homo sapiens 94-97 15292228-10 2004 These observations suggest that MPO promotes the formation of 3-chlorotyrosine and 3-nitrotyrosine in circulating HDL but that other pathways also produce 3-nitrotyrosine in atherosclerotic tissue. 3-chlorotyrosine 62-78 myeloperoxidase Homo sapiens 32-35 15466253-7 2004 There was a strong correlation between myeloperoxidase and 3-chlorotyrosine. 3-chlorotyrosine 59-75 myeloperoxidase Homo sapiens 39-54 15326314-11 2004 The detection of 3-chlorotyrosine in HDL isolated from vascular lesions raises the possibility that MPO, by virtue of its ability to form HOCl, may promote atherogenesis by counteracting the established antiatherogenic effects of HDL and the ATP-binding cassette transporter A1 pathway. 3-chlorotyrosine 17-33 myeloperoxidase Homo sapiens 100-103 9378370-0 1997 Mass spectrometric quantification of 3-chlorotyrosine in human tissues with attomole sensitivity: a sensitive and specific marker for myeloperoxidase-catalyzed chlorination at sites of inflammation. 3-chlorotyrosine 37-53 myeloperoxidase Homo sapiens 134-149 15196282-1 2004 BACKGROUND: Eosinophil peroxidase and myeloperoxidase halogenate tyrosine residues in plasma proteins and generate 3-bromotyrosine (BY) and 3-chlorotyrosine (CY), respectively. 3-chlorotyrosine 140-156 myeloperoxidase Homo sapiens 38-53 15196282-1 2004 BACKGROUND: Eosinophil peroxidase and myeloperoxidase halogenate tyrosine residues in plasma proteins and generate 3-bromotyrosine (BY) and 3-chlorotyrosine (CY), respectively. 3-chlorotyrosine 158-160 myeloperoxidase Homo sapiens 38-53 12651629-7 2003 3-Chlorotyrosine, a marker of neutrophil/myeloperoxidase-mediated protein damage was significantly increased from 1 hour after burn. 3-chlorotyrosine 0-16 myeloperoxidase Homo sapiens 41-56 12595594-0 2003 3-Chlorotyrosine as a marker of protein damage by myeloperoxidase in tracheal aspirates from preterm infants: association with adverse respiratory outcome. 3-chlorotyrosine 0-16 myeloperoxidase Homo sapiens 50-65 11705694-0 2001 Myeloperoxidase-catalyzed 3-chlorotyrosine formation in dialysis patients. 3-chlorotyrosine 26-42 myeloperoxidase Homo sapiens 0-15 11705694-3 2001 The phagocyte-derived myeloperoxidase-hydrogen peroxide-chloride system generates hypochlorous acid, which reacts with tyrosine residues of proteins to form 3-chlorotyrosine. 3-chlorotyrosine 157-173 myeloperoxidase Homo sapiens 22-37 11705694-4 2001 To explore the role of activated phagocytes in oxidative stress in chronic renal failure, we used 3-chlorotyrosine as a specific marker of myeloperoxidase activity. 3-chlorotyrosine 98-114 myeloperoxidase Homo sapiens 139-154 11020661-6 2000 Levels of 3-chlorotyrosine and 3,5-dichlorotyrosine are increased in proteins after exposure to low concentrations of hypochlorous acid and we conclude that their analysis by gas chromatography and mass spectrometry is currently the best method available for probing the involvement of oxidation by myeloperoxidase in the pathology of particular diseases. 3-chlorotyrosine 10-26 myeloperoxidase Homo sapiens 299-314 9151778-0 1997 3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima. 3-chlorotyrosine 0-16 myeloperoxidase Homo sapiens 39-54 9151778-7 1997 These results indicate that 3-chlorotyrosine is a specific marker for LDL oxidation by myeloperoxidase. 3-chlorotyrosine 28-44 myeloperoxidase Homo sapiens 87-102 9151778-11 1997 The detection of 3-chlorotyrosine in human atherosclerotic lesions indicates that halogenation reactions catalyzed by the myeloperoxidase system of phagocytes constitute one pathway for protein oxidation in vivo. 3-chlorotyrosine 17-33 myeloperoxidase Homo sapiens 122-137 9378370-3 1997 Previous in vitro studies demonstrated that 3-chlorotyrosine is a specific product of myeloperoxidase-catalyzed oxidative damage and that the chlorinated amino acid may thus serve as an index of phagocyte-mediated tissue injury in vivo. 3-chlorotyrosine 44-60 myeloperoxidase Homo sapiens 86-101 9378370-7 1997 The specificity, sensitivity, and reproducibility of 3-chlorotyrosine determination should make this method useful for exploring the role of myeloperoxidase in catalyzing oxidative reactions in vivo. 3-chlorotyrosine 53-69 myeloperoxidase Homo sapiens 141-156 33705529-7 2022 Interestingly, treatment with the MPO inhibitor, AZD5904, reduced 3-chlorotyrosine-modified MYBPC3 levels, restored MYBPC3 phosphorylation, and alleviated the calcium signalling and relaxation defects. 3-chlorotyrosine 66-82 myeloperoxidase Homo sapiens 34-37 8566218-4 1996 When albumin was exposed to reagent hypochlorous acid, or that produced by myeloperoxidase and stimulated neutrophils, tyrosyl residues in the protein were converted to chlorotyrosine. 3-chlorotyrosine 169-183 myeloperoxidase Homo sapiens 75-90 33705529-6 2022 The presence of cardiomyocyte MPO was associated with higher chlorination and peroxidation activity, increased levels of 3-chlorotyrosine-modified cardiac myosin binding protein-C (MYBPC3), attenuated phosphorylation of MYBPC3 at Ser-282, perturbed calcium signalling, and impaired cardiomyocyte relaxation. 3-chlorotyrosine 121-137 myeloperoxidase Homo sapiens 30-33 8823292-11 1996 In both models, synthesis of 3-chlorotyrosine was inhibited by heme poisons and the peroxide scavenger catalase, implicating the myeloperoxidase-hydrogen peroxide system in the reaction. 3-chlorotyrosine 29-45 myeloperoxidase Homo sapiens 129-144