PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32692218-7 2020 In addition, 6-gingerol could suppress the phosphorylation level of IkappaBalpha and p65, which was up-regulated by DSS. gingerol 13-23 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 85-88 32692218-8 2020 Further analysis with immunohistochemistry indicated p-p65 staining was mainly in the nucleus with some in the cytoplasm after DSS treatment, and the treatment with 6-gingerol could significantly weaken the density of p-p65 both in the cytoplasm and nucleus. gingerol 165-175 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 55-58 32692218-8 2020 Further analysis with immunohistochemistry indicated p-p65 staining was mainly in the nucleus with some in the cytoplasm after DSS treatment, and the treatment with 6-gingerol could significantly weaken the density of p-p65 both in the cytoplasm and nucleus. gingerol 165-175 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 220-223 16732525-7 2006 This occurred at the transcriptional level, since the gingerol compounds decreased LPS-induced IkappaB-alpha degradation, prevented nuclear translocation of NF-kappaB p65 and reduced NF-kappaB activity in a concentration-dependent manner. gingerol 54-62 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 167-170 15735738-6 2005 Pretreatment with [6]-gingerol resulted in a decrease in both TPA-induced DNA binding and transcriptional activities of NF-kappaB through suppression of IkappaBalpha degradation and p65 nuclear translocation. gingerol 18-30 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 182-185 15735738-7 2005 Phosphorylation of both IkappaBalpha and p65 was substantially blocked by [6]-gingerol. gingerol 74-86 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 41-44 15735738-8 2005 In addition, [6]-gingerol inhibited TPA-stimulated interaction of phospho-p65-(Ser-536) with cAMP response element binding protein-binding protein, a transcriptional coactivator of NF-kappaB. gingerol 13-25 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 74-77