PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15735738-0	2005	[6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin.	gingerol	4-12	mitogen-activated protein kinase 14	Mus musculus	69-72	
15630166-0	2004	Inhibitory effects of [6]-gingerol on PMA-induced COX-2 expression and activation of NF-kappaB and p38 MAPK in mouse skin.	gingerol	22-34	mitogen-activated protein kinase 14	Mus musculus	99-102	
15630166-7	2004	In addition, [6]-gingerol inhibited the phoshorylation of p38 mitogen-activated protein kinase which may account for its inactivation of NF-kappaB and suppression of COX-2 expression.	gingerol	13-25	mitogen-activated protein kinase 14	Mus musculus	58-61	
33462378-8	2021	Furthermore, 6-gingerol treatment significantly decreased mitogen-activated protein kinase p38 (p38) phosphorylation in response to pressure overload in vivo and extracellular stimuli in vitro, which was upregulated in the absence of 6-gingerol treatment.	gingerol	13-23	mitogen-activated protein kinase 14	Mus musculus	91-94	
33462378-8	2021	Furthermore, 6-gingerol treatment significantly decreased mitogen-activated protein kinase p38 (p38) phosphorylation in response to pressure overload in vivo and extracellular stimuli in vitro, which was upregulated in the absence of 6-gingerol treatment.	gingerol	13-23	mitogen-activated protein kinase 14	Mus musculus	96-99	
33462378-9	2021	Moreover, transfection with mitogen-activated protein kinase kinase 6 expressing adenoviruses (Ad-MKK6), which specifically activated p38, abolished the protective effects of 6-gingerol in both in vitro and in vivo models.	gingerol	175-185	mitogen-activated protein kinase 14	Mus musculus	134-137	
33462378-10	2021	In conclusion, 6-gingerol improves cardiac function and alleviates cardiac remodeling induced by pressure overload in a p38-dependent manner.	gingerol	15-25	mitogen-activated protein kinase 14	Mus musculus	120-123	
32438504-9	2020	Further, [6]-gingerol improved ISO-induced morphological pathologies, reduced the expression of TNF-alpha, IL-6, c-fos, c-jun, Bax, Caspase-3, TLR4, NF-kappaB, p38, p-p38, ERK1/2, p-ERK1/2, JNK, and p-JNK, and increased Bcl-2 protein expression.	gingerol	9-21	mitogen-activated protein kinase 14	Mus musculus	160-163	
32438504-9	2020	Further, [6]-gingerol improved ISO-induced morphological pathologies, reduced the expression of TNF-alpha, IL-6, c-fos, c-jun, Bax, Caspase-3, TLR4, NF-kappaB, p38, p-p38, ERK1/2, p-ERK1/2, JNK, and p-JNK, and increased Bcl-2 protein expression.	gingerol	9-21	mitogen-activated protein kinase 14	Mus musculus	167-170	
15735738-9	2005	Moreover, [6]-gingerol prevented TPA-induced phosphorylation and catalytic activity of p38 mitogen-activated protein (MAP) kinase that regulates COX-2 expression in mouse skin.	gingerol	14-22	mitogen-activated protein kinase 14	Mus musculus	87-90	
15735738-11	2005	Taken together, our data suggest that [6]-gingerol inhibits TPA-induced COX-2 expression in mouse skin in vivo by blocking the p38 MAP kinase-NF-kappaB signaling pathway.	gingerol	38-50	mitogen-activated protein kinase 14	Mus musculus	127-130