PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35347963-9 2022 Additionally, 6-gingerol at a high dose significantly increased the protein and mRNA expression of APN, AdipoR1, PGC-1alpha, and PI3 K in eWAT, elevated the relative expression of p-AMPK~(Thr172) and p-Akt~(Ser 473), reduced the protein and mRNA expression of TNF-alpha, IL-1, and IL-6 in eWAT, and decreased the relative expression of p-JNK1 and p-JNK2. gingerol 14-24 tumor necrosis factor Rattus norvegicus 260-269 32928188-15 2020 Western blot and RT-qPCR showed that 6-gingerol inhibited the expression of proinflammatory factors (TNF-alpha, IL-6, iNOS) in CECs, and inhibition of IkappaBalpha degradation and phosphorylation of p65 involved in NF-kappaB pathway. gingerol 37-47 tumor necrosis factor Rattus norvegicus 101-110 28113081-4 2017 RESULTS: 6-Gingerol substantially enhanced phosphorylated AMPK-alpha1 more than fish oil and reduced the P65 via upregulation of Sirt-6 and downregulation of resistin, and resulted in attenuation of the inflammatory molecules P65, FFAs and TNF-alpha more than fish oil treated groups but in an insignificant statistical manner, those effects were accompanied by a substantial hypoglycemic effect. gingerol 9-19 tumor necrosis factor Rattus norvegicus 240-249 30257370-9 2018 Besides, 6-gingerol inhibited LPS-induced increases in levels of GFAP and TNF-alpha in the rat brain. gingerol 9-19 tumor necrosis factor Rattus norvegicus 74-83