PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35566044-8	2022	A real-time PCR study showed that 6-Gingerol induces the simultaneous transcription of Bax with TP53 genes in large excess to BCL-2.	gingerol	34-44	tumor protein p53	Homo sapiens	96-100	
33925065-0	2021	Potential Antitumor Effects of 6-Gingerol in p53-Dependent Mitochondrial Apoptosis and Inhibition of Tumor Sphere Formation in Breast Cancer Cells.	gingerol	31-41	tumor protein p53	Homo sapiens	45-48	
33925065-7	2021	6-Gingerol induced cellular and mitochondrial ROS that elevated DDR through ataxia-telangiectasia mutated and p53 activation.	gingerol	0-10	tumor protein p53	Homo sapiens	110-113	
33925065-10	2021	EGFR/Src/STAT3 signaling was also determined to be responsible for p53 activation and that 6-gingerol induced p53-dependent intrinsic apoptosis in breast cancer cells.	gingerol	91-101	tumor protein p53	Homo sapiens	110-113	
32483405-0	2020	Bioinformatics and experimental studies of anti-leukemic activity from 6-gingerol demonstrate its role in p53 mediated apoptosis pathway.	gingerol	71-81	tumor protein p53	Homo sapiens	106-109	
32483405-9	2020	Moreover, it was found that 6-gingerol could increase the levels of p53 mRNA in all leukemic cell lines.	gingerol	28-38	tumor protein p53	Homo sapiens	68-71	
22719783-8	2012	In addition, 6-gingerol treatment elevated intracellular reactive oxygen species (ROS) and phosphorylation level of p53.	gingerol	13-23	tumor protein p53	Homo sapiens	116-119	
22719783-9	2012	These findings indicate that exposure of 6-gingerol may induce intracellular ROS and upregulate p53, p27(Kip1), and p21(Cip1) levels leading to consequent decrease of CDK1, cyclin A, and cyclin B1 as result of cell cycle arrest in LoVo cells.	gingerol	41-51	tumor protein p53	Homo sapiens	96-99	
17066513-0	2006	[6]-Gingerol induces cell cycle arrest and cell death of mutant p53-expressing pancreatic cancer cells.	gingerol	4-12	tumor protein p53	Homo sapiens	64-67	
17066513-3	2006	The purpose of this study was to investigate the action of [6]-gingerol on two human pancreatic cancer cell lines, HPAC expressing wild- type (wt) p53 and BxPC-3 expressing mutated p53.	gingerol	59-71	tumor protein p53	Homo sapiens	181-184	
17066513-7	2006	p53 expression was decreased by [6]-gingerol treatment in both cell lines suggesting that the induction of Cyclin-dependent kinase inhibitor, p21cip1, was p53-independent.	gingerol	36-44	tumor protein p53	Homo sapiens	0-3	
17066513-8	2006	[6]-Gingerol induced mostly apoptotic death in the mutant p53-expressing cells, while no signs of early apoptosis were detected in wild type p53-expressing cells and this was related to the increased phosphorylation of AKT.	gingerol	4-12	tumor protein p53	Homo sapiens	58-61	
17066513-9	2006	These results suggest that [6]-gingerol can circumvent the resistance of mutant p53- expressing cells towards chemotherapy by inducing apoptotic cell death while it exerts cytostatic effect on wild type p53- expressing cells by inducing temporal growth arrest.	gingerol	27-39	tumor protein p53	Homo sapiens	80-83	
17066513-9	2006	These results suggest that [6]-gingerol can circumvent the resistance of mutant p53- expressing cells towards chemotherapy by inducing apoptotic cell death while it exerts cytostatic effect on wild type p53- expressing cells by inducing temporal growth arrest.	gingerol	27-39	tumor protein p53	Homo sapiens	203-206