PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22389213-10 2012 Taken together, these results suggest that cathepsin D may be a positive mediator of 6-gingerol induced apoptosis in HepG2 cells, acting upstream of cytochrome c release, and the apoptosis may be associated with oxidative stress. gingerol 85-95 cytochrome c, somatic Homo sapiens 149-161 22939973-8 2012 On the other hand the expression levels of TNFalpha, Bax and cytochrome c were enhanced in [6]-gingerol treated cells. gingerol 95-103 cytochrome c, somatic Homo sapiens 61-73 28315687-5 2017 The inhibitory effect of [10]-gingerol on the growth of MDA-MB-231 cells was associated with a reduction in the number of rounds of cell division and evidence of S phase-cell cycle arrest, as well as induction of apoptosis due to mitochondrial outer membrane permeabilization and the release of proapoptotic mitochondrial cytochrome c and SMAC/DIABLO into the cytoplasm. gingerol 25-38 cytochrome c, somatic Homo sapiens 322-334 33925065-8 2021 6-Gingerol also induced G0/G1 cell cycle arrest and mitochondrial apoptosis by mediating the BAX/BCL-2 ratio and release of cytochrome c. gingerol 0-10 cytochrome c, somatic Homo sapiens 124-136