PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20521273-6 2010 Upon incubation of PMA-treated HepG2 cells and PMA-untreated Hep3B cells with 6-shogaol and 6-gingerol, matrix metalloproteinase (MMP)-9 activity decreased, whereas the expression of tissue inhibitor metalloproteinase protein (TIMP)-1 increased in both cell types. gingerol 92-102 TIMP metallopeptidase inhibitor 1 Homo sapiens 183-234 20521273-8 2010 CONCLUSIONS: These results suggest that 6-shogaol and 6-gingerol might both exert anti-invasive activity against hepatoma cells through regulation of MMP-9 and TIMP-1 and that 6-shogaol could further regulate urokinase-type plasminogen activity. gingerol 54-64 TIMP metallopeptidase inhibitor 1 Homo sapiens 160-166