PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17683926-8	2008	The activities of MMP-2 or MMP-9 in MDA-MB-231 cells were decreased by treatment with [6]-gingerol and occurred in a dose-dependent manner.	gingerol	86-98	matrix metallopeptidase 9	Homo sapiens	27-32	
24204396-0	2013	[6]-Gingerol Prevents Disassembly of Cell Junctions and Activities of MMPs in Invasive Human Pancreas Cancer Cells through ERK/NF- kappa B/Snail Signal Transduction Pathway.	gingerol	0-12	matrix metallopeptidase 9	Homo sapiens	70-74	
24204396-4	2013	TJ protein levels, including zonula occludens (ZO-) 1, occludin, and E-cadherin, increased in [6]-gingerol-treated cells, which correlated with a decrease in paracellular flux and MMP activity.	gingerol	98-106	matrix metallopeptidase 9	Homo sapiens	180-183	
20521273-6	2010	Upon incubation of PMA-treated HepG2 cells and PMA-untreated Hep3B cells with 6-shogaol and 6-gingerol, matrix metalloproteinase (MMP)-9 activity decreased, whereas the expression of tissue inhibitor metalloproteinase protein (TIMP)-1 increased in both cell types.	gingerol	92-102	matrix metallopeptidase 9	Homo sapiens	104-136	
20521273-7	2010	Additionally, urokinase-type plasminogen activator activity was dose-dependently decreased in Hep3B cells after incubation with 6-shogaol for 24 h. Analysis with semi-quantitative reverse transcription-PCR showed that the regulation of MMP-9 by 6-shogaol and 6-gingerol and the regulation of TIMP-1 by 6-shogaol in Hep3B cells may on the transcriptional level.	gingerol	259-269	matrix metallopeptidase 9	Homo sapiens	236-241	
20521273-8	2010	CONCLUSIONS: These results suggest that 6-shogaol and 6-gingerol might both exert anti-invasive activity against hepatoma cells through regulation of MMP-9 and TIMP-1 and that 6-shogaol could further regulate urokinase-type plasminogen activity.	gingerol	54-64	matrix metallopeptidase 9	Homo sapiens	150-155	
25323950-5	2014	The 13 constituent compounds of SCRT water extract were quantitatively determined, and it was found that gallic acid, 6-gingerol and methyl eugenol produced the most potent inhibition of RANTES, eotaxin and eotaxin-3 as well as MMP-9 activity regardless of their concentration in SCRT water extract.	gingerol	118-128	matrix metallopeptidase 9	Homo sapiens	228-233	
17683926-10	2008	MMP-2 and MMP-9 mRNA expression were decreased by [6]-gingerol treatment.	gingerol	54-62	matrix metallopeptidase 9	Homo sapiens	10-15	
17683926-11	2008	In conclusion, we have shown that [6]-gingerol inhibits cell adhesion, invasion, motility and activities of MMP-2 and MMP-9 in MDA-MB-231 human breast cancer cell lines.	gingerol	34-46	matrix metallopeptidase 9	Homo sapiens	118-123