PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33505603-14	2020	6-GIN could increase Bcl-2 expression and decrease Bax and caspase-3 expression.	gingerol	0-5	caspase 3	Homo sapiens	59-68	
25221872-7	2014	Combined EGCG + GING induced apoptosis in both 1321N1 and LN18 cells, as evidenced by Annexin-V FITC/PI staining and increased active caspase-3.	gingerol	16-20	caspase 3	Homo sapiens	134-143	
30886640-7	2019	6-Gingerol administration also inhibited I/R-induced HMGB2 expression upregulation and JNK activation and reduced Cleaved Poly(ADP-ribose) polymerases (PARP) and Caspase-3 expression.	gingerol	0-10	caspase 3	Homo sapiens	162-171	
26749462-7	2016	6-Gingerol, wortmannin, and rapamycin treatment showed almost two-fold higher expression of caspase 3 in all cell lines.	gingerol	0-10	caspase 3	Homo sapiens	92-101	
25148824-4	2015	Analysis of the mechanism of these events indicated that [10]-gingerol-treated cells exhibited an increased ratio of Bax/Bcl-2, resulting in the activation of caspase-9, caspase-3, and poly-ADP-ribose polymerase in a dose-dependent manner, which are hallmarks of apoptosis.	gingerol	62-70	caspase 3	Homo sapiens	170-179	
21396424-3	2011	[6]-Gingerol pretreatment protected against Abeta(25-35)-induced cytotoxicity and apoptotic cell death such as DNA fragmentation, disruption of mitochondrial membrane potential, elevated Bax/Bcl-2 ratio, and activation of caspase-3.	gingerol	4-12	caspase 3	Homo sapiens	222-231	
22939973-0	2012	[6]-Gingerol induces caspase 3 dependent apoptosis and autophagy in cancer cells: drug-DNA interaction and expression of certain signal genes in HeLa cells.	gingerol	0-12	caspase 3	Homo sapiens	21-30	
22939973-5	2012	The expression of caspase 3 and PARP was increased in cells exposed to [6]-gingerol.	gingerol	71-83	caspase 3	Homo sapiens	18-27	
22939973-9	2012	Thus, overall results suggest that [6]-gingerol has potential to bind with DNA and induce cell death by autophagy and caspase 3 mediated apoptosis.	gingerol	39-47	caspase 3	Homo sapiens	118-127