PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25221872-7 2014 Combined EGCG + GING induced apoptosis in both 1321N1 and LN18 cells, as evidenced by Annexin-V FITC/PI staining and increased active caspase-3. gingerol 16-20 caspase 3 Homo sapiens 134-143 26749462-7 2016 6-Gingerol, wortmannin, and rapamycin treatment showed almost two-fold higher expression of caspase 3 in all cell lines. gingerol 0-10 caspase 3 Homo sapiens 92-101 25148824-4 2015 Analysis of the mechanism of these events indicated that [10]-gingerol-treated cells exhibited an increased ratio of Bax/Bcl-2, resulting in the activation of caspase-9, caspase-3, and poly-ADP-ribose polymerase in a dose-dependent manner, which are hallmarks of apoptosis. gingerol 62-70 caspase 3 Homo sapiens 170-179 33505603-14 2020 6-GIN could increase Bcl-2 expression and decrease Bax and caspase-3 expression. gingerol 0-5 caspase 3 Homo sapiens 59-68 30886640-7 2019 6-Gingerol administration also inhibited I/R-induced HMGB2 expression upregulation and JNK activation and reduced Cleaved Poly(ADP-ribose) polymerases (PARP) and Caspase-3 expression. gingerol 0-10 caspase 3 Homo sapiens 162-171 22939973-0 2012 [6]-Gingerol induces caspase 3 dependent apoptosis and autophagy in cancer cells: drug-DNA interaction and expression of certain signal genes in HeLa cells. gingerol 0-12 caspase 3 Homo sapiens 21-30 22939973-5 2012 The expression of caspase 3 and PARP was increased in cells exposed to [6]-gingerol. gingerol 71-83 caspase 3 Homo sapiens 18-27 22939973-9 2012 Thus, overall results suggest that [6]-gingerol has potential to bind with DNA and induce cell death by autophagy and caspase 3 mediated apoptosis. gingerol 39-47 caspase 3 Homo sapiens 118-127 21396424-3 2011 [6]-Gingerol pretreatment protected against Abeta(25-35)-induced cytotoxicity and apoptotic cell death such as DNA fragmentation, disruption of mitochondrial membrane potential, elevated Bax/Bcl-2 ratio, and activation of caspase-3. gingerol 4-12 caspase 3 Homo sapiens 222-231