PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35347963-9	2022	Additionally, 6-gingerol at a high dose significantly increased the protein and mRNA expression of APN, AdipoR1, PGC-1alpha, and PI3 K in eWAT, elevated the relative expression of p-AMPK~(Thr172) and p-Akt~(Ser 473), reduced the protein and mRNA expression of TNF-alpha, IL-1, and IL-6 in eWAT, and decreased the relative expression of p-JNK1 and p-JNK2.	gingerol	14-24	AKT serine/threonine kinase 1	Rattus norvegicus	202-205	
35347963-10	2022	This study reveals that 6-gingerol can improve insulin sensitivity of adipose tissues in aging rats with glycolipid metabolism disorders, and this effect is presumedly achieved by enhancing the PI3 K/Akt signaling pathway, inhibiting adipose tissue inflammation, increasing APN synthesis, enhancing AdipoR1 expression, and activating its downstream AMPK/PGC-1alpha signaling pathway.	gingerol	24-34	AKT serine/threonine kinase 1	Rattus norvegicus	200-203	
31316575-0	2019	Corrigendum to "6-Gingerol Protects Heart by Suppressing Myocardial Ischemia/Reperfusion Induced Inflammation via the PI3K/Akt-Dependent Mechanism in Rats".	gingerol	16-26	AKT serine/threonine kinase 1	Rattus norvegicus	123-126	
30408433-8	2019	Our results showed 6-gingerol exerted a positive effect on insulin sensitivity by regulating Akt.	gingerol	19-29	AKT serine/threonine kinase 1	Rattus norvegicus	93-96	
30575271-3	2019	6-Gingerol can attenuate age-associated high plasma triglyceride, glucose, and insulin concentrations under fasting conditions as well as suppress the increase in the HOMA-IR index and inhibit the decrease of muscular p-Akt/Akt protein in ageing rats, which indicates an improvement of systemic and muscular insulin sensitivity.	gingerol	0-10	AKT serine/threonine kinase 1	Rattus norvegicus	220-223	
30575271-3	2019	6-Gingerol can attenuate age-associated high plasma triglyceride, glucose, and insulin concentrations under fasting conditions as well as suppress the increase in the HOMA-IR index and inhibit the decrease of muscular p-Akt/Akt protein in ageing rats, which indicates an improvement of systemic and muscular insulin sensitivity.	gingerol	0-10	AKT serine/threonine kinase 1	Rattus norvegicus	224-227	
25811848-6	2015	In addition, 6-gingerol pretreatment also significantly enhanced the protein levels of phosphorylated Akt (p-Akt) and glycogen synthase kinase-3beta (p-GSK-3beta).	gingerol	13-23	AKT serine/threonine kinase 1	Rattus norvegicus	109-112	
30519268-0	2018	6-Gingerol Protects Heart by Suppressing Myocardial Ischemia/Reperfusion Induced Inflammation via the PI3K/Akt-Dependent Mechanism in Rats.	gingerol	0-10	AKT serine/threonine kinase 1	Rattus norvegicus	107-110	
29743926-0	2018	6-Gingerol Activates PI3K/Akt and Inhibits Apoptosis to Attenuate Myocardial Ischemia/Reperfusion Injury.	gingerol	0-10	AKT serine/threonine kinase 1	Rattus norvegicus	26-29	
29743926-9	2018	Taken together, these findings suggest that 6-G inhibits apoptosis and activates PI3K/Akt signaling in response to myocardial I/R injury as a possible mechanism to attenuate I/R-induced injury in heart.	gingerol	44-47	AKT serine/threonine kinase 1	Rattus norvegicus	86-89	
25811848-6	2015	In addition, 6-gingerol pretreatment also significantly enhanced the protein levels of phosphorylated Akt (p-Akt) and glycogen synthase kinase-3beta (p-GSK-3beta).	gingerol	13-23	AKT serine/threonine kinase 1	Rattus norvegicus	102-105	
25811848-7	2015	Overall, these results indicate that 6-gingerol exhibited protective effects on apoptosis induced by Abeta1-42 in cultured PC12 cells by reducing oxidative stress and inflammatory responses, suppressing the activation of GSK-3beta and enhancing the activation of Akt, thereby exerting neuroprotective effects.	gingerol	37-47	AKT serine/threonine kinase 1	Rattus norvegicus	263-266	
23861719-9	2013	In conclusion, combination of higenamine and [6]-gingerol exerts cardioprotective effect against doxorubicin-induced cardiotoxicity through activating the PI3K/Akt signaling pathway.	gingerol	45-57	AKT serine/threonine kinase 1	Rattus norvegicus	160-163