PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35566044-8	2022	A real-time PCR study showed that 6-Gingerol induces the simultaneous transcription of Bax with TP53 genes in large excess to BCL-2.	gingerol	34-44	BCL2 associated X, apoptosis regulator	Homo sapiens	87-90	
33505603-14	2020	6-GIN could increase Bcl-2 expression and decrease Bax and caspase-3 expression.	gingerol	0-5	BCL2 associated X, apoptosis regulator	Homo sapiens	51-54	
33925065-8	2021	6-Gingerol also induced G0/G1 cell cycle arrest and mitochondrial apoptosis by mediating the BAX/BCL-2 ratio and release of cytochrome c.	gingerol	0-10	BCL2 associated X, apoptosis regulator	Homo sapiens	93-96	
24624885-8	2013	Along with the growth inhibition of DPCs by 6-gingerol, the Bax/Bcl-2 ratio increased obviously.	gingerol	44-54	BCL2 associated X, apoptosis regulator	Homo sapiens	60-63	
25148824-4	2015	Analysis of the mechanism of these events indicated that [10]-gingerol-treated cells exhibited an increased ratio of Bax/Bcl-2, resulting in the activation of caspase-9, caspase-3, and poly-ADP-ribose polymerase in a dose-dependent manner, which are hallmarks of apoptosis.	gingerol	62-70	BCL2 associated X, apoptosis regulator	Homo sapiens	117-120	
24624885-10	2013	CONCLUSIONS: 6-Gingerol can suppress human hair shaft elongation because it has pro-apoptotic effects on DPCs via increasing Bax/Bcl-2 ratio.	gingerol	13-23	BCL2 associated X, apoptosis regulator	Homo sapiens	125-128	
23437345-6	2013	The growth inhibition of DPCs by 6-gingerol in vitro may reflect a decrease in the Bcl-2/Bax ratio.	gingerol	33-43	BCL2 associated X, apoptosis regulator	Homo sapiens	89-92	
22939973-8	2012	On the other hand the expression levels of TNFalpha, Bax and cytochrome c were enhanced in [6]-gingerol treated cells.	gingerol	95-103	BCL2 associated X, apoptosis regulator	Homo sapiens	53-56	
21396424-3	2011	[6]-Gingerol pretreatment protected against Abeta(25-35)-induced cytotoxicity and apoptotic cell death such as DNA fragmentation, disruption of mitochondrial membrane potential, elevated Bax/Bcl-2 ratio, and activation of caspase-3.	gingerol	4-12	BCL2 associated X, apoptosis regulator	Homo sapiens	187-190