PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16653244-2 1992 Various studies have shown that mevalonic acid-derived compounds are required for growth of plant and animal cells, a conclusion supported by the observation that cells treated with lovastatin (a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase) cease growth. Lovastatin 182-192 3-hydroxy-3-methylglutaryl-coenzyme A reductase Nicotiana tabacum 216-263 12736259-3 2003 Treatment of Tobacco Bright Yellow-2 (TBY-2) cells by the HMGR-specific inhibitor mevinolin led to growth reduction and induction of apparent HMGR activity, in parallel to an increase in protein representing two HMGR isozymes. Lovastatin 82-91 3-hydroxy-3-methylglutaryl-coenzyme A reductase Nicotiana tabacum 58-62 12736259-3 2003 Treatment of Tobacco Bright Yellow-2 (TBY-2) cells by the HMGR-specific inhibitor mevinolin led to growth reduction and induction of apparent HMGR activity, in parallel to an increase in protein representing two HMGR isozymes. Lovastatin 82-91 3-hydroxy-3-methylglutaryl-coenzyme A reductase Nicotiana tabacum 142-146 12736259-3 2003 Treatment of Tobacco Bright Yellow-2 (TBY-2) cells by the HMGR-specific inhibitor mevinolin led to growth reduction and induction of apparent HMGR activity, in parallel to an increase in protein representing two HMGR isozymes. Lovastatin 82-91 3-hydroxy-3-methylglutaryl-coenzyme A reductase Nicotiana tabacum 142-146 12736259-5 2003 Furthermore, DX partially re-established feedback repression of mevinolin-induced HMGR activity. Lovastatin 64-73 3-hydroxy-3-methylglutaryl-coenzyme A reductase Nicotiana tabacum 82-86 10938345-1 2000 Growth inhibition of tobacco (Nicotiana tabacum L. cv Bright Yellow-2) cells by mevinolin, a specific inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) could be partially overcome by the addition of farnesol. Lovastatin 80-89 3-hydroxy-3-methylglutaryl-coenzyme A reductase Nicotiana tabacum 115-162 10938345-1 2000 Growth inhibition of tobacco (Nicotiana tabacum L. cv Bright Yellow-2) cells by mevinolin, a specific inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR) could be partially overcome by the addition of farnesol. Lovastatin 80-89 3-hydroxy-3-methylglutaryl-coenzyme A reductase Nicotiana tabacum 164-168 10938345-6 2000 Both mevinolin and farnesol treatments stimulated apparent HMGR activity. Lovastatin 5-14 3-hydroxy-3-methylglutaryl-coenzyme A reductase Nicotiana tabacum 59-63