PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35459869-0 2022 AGR2-induced cholesterol synthesis drives lovastatin resistance that is overcome by combination therapy with allicin. Lovastatin 42-52 anterior gradient 2 Mus musculus 0-4 35459869-6 2022 Moreover, elevated AGR2 led to a significant decrease in the lipid-lowering efficacy of lovastatin (10 mg kg-1 d-1, ip, for 2 weeks) in mice with hypercholesterolemia (hyperCho), which was validated by results obtained from clinical samples in statin-treated patients. Lovastatin 88-98 anterior gradient 2 Mus musculus 19-23 35459869-9 2022 Importantly, the AGR2-reduced lipid-lowering efficacy of lovastatin was attenuated, at least partially, by co-administration of a sulfhydryl-reactive compound allicin (20 mg kg-1 d-1, ip, for 2 weeks). Lovastatin 57-67 anterior gradient 2 Mus musculus 17-21