PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12196129-6 2002 In humans, lovastatin, an HMG-CoA reductase inhibitor, has been shown to reduce A beta levels in blood of patients by up to 40%. Lovastatin 11-21 amyloid beta precursor protein Homo sapiens 80-86 26096465-6 2015 We demonstrated that lovastatin can differentially affect the expression of APP and Abeta production in vivo and in vitro. Lovastatin 21-31 amyloid beta precursor protein Homo sapiens 76-89 17907956-7 2007 This is indicated by a reported ability of micromolar concentrations of lovastatin and simvastatin to strongly stimulate brain vascular endothelial cells to make this Abeta ejector. Lovastatin 72-82 amyloid beta precursor protein Homo sapiens 167-172 16675062-0 2006 Influence of cholesterol and lovastatin on alpha-form of secreted amyloid precursor protein and expression of alpha7 nicotinic receptor on astrocytes. Lovastatin 29-39 amyloid beta precursor protein Homo sapiens 66-91 16675062-1 2006 The influence of cholesterol and the lovastatin (cholesterol-lowering drug) on secretion of alpha-secretase cleavage product of amyloid precursor protein (APP) and expression of nicotinic acetylcholine receptors (nAChRs) was investigated in human HTB-15 astrocytes. Lovastatin 37-47 amyloid beta precursor protein Homo sapiens 128-153 29341888-0 2018 Protection against the Neurotoxic Effects of beta-Amyloid Peptide on Cultured Neuronal Cells by Lovastatin Involves Elevated Expression of alpha7 Nicotinic Acetylcholine Receptors and Activating Phosphorylation of Protein Kinases. Lovastatin 96-106 amyloid beta precursor protein Homo sapiens 45-65 29341888-2 2018 To examine the pleiotropic cholesterol-independent effects of statins in connection with the treatment of Alzheimer disease, we probed the influence of lovastatin on the metabolism of amyloid precursor protein (APP), expression of nicotinic acetylcholine receptors (nAChRs), and activity of mitogen-activated protein kinase (MAPK) in primary cultured neurons and SH-SY5Y cells overexpressing human APP670/671. Lovastatin 152-162 amyloid beta precursor protein Homo sapiens 184-209 29341888-3 2018 Lovastatin attenuated the neurotoxic effects of beta-amyloid peptide (Abeta) and affected the metabolism of APP, reducing levels of Abeta1 to Abeta42 and beta-site amyloid precursor protein-cleaving enzyme 1; enhancing those of alphaAPP, disintegrin metalloproteinase domain-containing protein 10, and beta-site amyloid precursor protein-cleaving enzyme 2; and up-regulating expression of alpha7 nAChR and stimulating phosphorylation of extracellular signal-regulated kinase (ERK)1/2. Lovastatin 0-10 amyloid beta precursor protein Homo sapiens 48-68 17234346-0 2007 Lovastatin protects human neurons against Abeta-induced toxicity and causes activation of beta-catenin-TCF/LEF signaling. Lovastatin 0-10 amyloid beta precursor protein Homo sapiens 42-47 17234346-5 2007 Lovastatin has been shown to decrease the production of Abeta and to promote neuronal survival. Lovastatin 0-10 amyloid beta precursor protein Homo sapiens 56-61 17234346-8 2007 Here, we report that lovastatin prevented Abeta-induced apoptosis in human SK-NSH cells. Lovastatin 21-31 amyloid beta precursor protein Homo sapiens 42-47 17234346-12 2007 Our results suggest that lovastatin protects neuronal cells from Abeta-induced apoptosis and causes reduction in GSK-3beta activity, resulting in activation of Wnt signaling. Lovastatin 25-35 amyloid beta precursor protein Homo sapiens 65-70 11900994-10 2002 Our results suggest a mechanism by which hypercholesterolemia may increase risk for AD and indicate that lovastatin reduces Abeta formation and may thereby be effective in delaying the onset and/or slowing the progression of AD. Lovastatin 105-115 amyloid beta precursor protein Homo sapiens 124-129 11900994-0 2002 Pharmacological concentrations of the HMG-CoA reductase inhibitor lovastatin decrease the formation of the Alzheimer beta-amyloid peptide in vitro and in patients. Lovastatin 66-76 amyloid beta precursor protein Homo sapiens 117-137 10501560-1 1999 Addition of the beta-hydroxy-beta-methylglutaryl-CoA (HmG-CoA) reductase inhibitor lovastatin to human HEK cells transfected with the amyloid precursor protein (APP) reduces intracellular cholesterol/protein ratios by 50%, and markedly inhibits beta-secretase cleavage of newly-synthesized APP. Lovastatin 83-93 amyloid beta precursor protein Homo sapiens 134-159 11466161-0 2001 Treatment with controlled-release lovastatin decreases serum concentrations of human beta-amyloid (A beta) peptide. Lovastatin 34-44 amyloid beta precursor protein Homo sapiens 85-105 11466161-2 2001 Studies in vitro have shown that inhibiting cholesterol metabolism with lovastatin, or its active metabolite lovastatin acid, lowers A beta production. Lovastatin 72-82 amyloid beta precursor protein Homo sapiens 133-139 9600988-4 1998 By reducing the cellular cholesterol level of living hippocampal neurons by 70% with lovastatin and methyl-beta-cyclodextrin, we show that the formation of Abeta is completely inhibited while the generation of APPsec is unperturbed. Lovastatin 85-95 amyloid beta precursor protein Homo sapiens 156-161