PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14612203-4	2003	Lovastatin, simvastatin, atorvastatin, fluvastatin and cerivastatin, which are hydrophobic statins, markedly reduced cell viability associated with DNA fragmentation, DNA laddering and activation of caspase-3, suggesting apoptotic cell death.	Lovastatin	0-10	caspase 3	Rattus norvegicus	199-208	
17497701-6	2008	We demonstrated that lovastatin (0.01-1 microM) remarkably prevented MSCs from Hypoxia/SD-induced apoptosis through inhibition of the mitochondrial apoptotic pathway, leading to attenuation of caspase-3 activation.	Lovastatin	21-31	caspase 3	Rattus norvegicus	193-202	
18466319-7	2008	Concomitantly, lovastatin causes a decrease in eIF4G cellular amount, which is partially mediated by caspase(s) activity excluding caspase 3.	Lovastatin	15-25	caspase 3	Rattus norvegicus	131-140	
19100107-5	2008	RESULTS: Lovastatin (0.01 - 1 micromol/L) significantly reduced Hypoxia/SD-induced MSCs apoptosis and increased Akt phosphorylation, reduced caspase-3 activation and cytochrome c release from mitochondria to cytosol in a time dependent manner.	Lovastatin	9-19	caspase 3	Rattus norvegicus	141-150	
16427097-8	2006	Specifically, we demonstrate that 3 statins, simvastatin, lovastatin, and mevastatin induce dose-dependent apoptosis in the TR-PCT1 pericyte cell line, that simvastatin (empirically shown to be the most potent of the 3 statins) induces similar levels of apoptosis in freshly isolated pericytes, and that simvastatin-induced apoptosis in pericytes is cholesterol, caspase-3, and caspase-7 mediated.	Lovastatin	58-68	caspase 3	Rattus norvegicus	363-372	
17251057-8	2007	Furthermore, we found that the activation of the JNK signalling pathway triggered by lovastatin is accompanied by caspase-3 activation which is also inhibited by iJNK-I pre-treatment.	Lovastatin	85-95	caspase 3	Rattus norvegicus	114-123	
16367743-3	2006	We found that lovastatin exposure induced focal adhesion kinase, Crk-associated substrate (p130(Cas)), PKCdelta cleavage and caspase-3 activation in a concentration-dependent manner.	Lovastatin	14-24	caspase 3	Rattus norvegicus	125-134	
16367743-6	2006	In contrast, the lovastatin-induced cleavage of PKCdelta was only blocked by z-VAD-fmk suggesting that PKCdelta cleavage is caspase-dependent but caspase-3-independent.	Lovastatin	17-27	caspase 3	Rattus norvegicus	146-155