PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31406237-0 2020 Human H1 receptor (HRH1) gene polymorphism is associated with the severity of side effects after desloratadine treatment in Chinese patients with chronic spontaneous uticaria. desloratadine 97-110 histamine receptor H1 Homo sapiens 19-23 31406237-3 2020 Herein, we evaluated the association between HRH1 gene rs901865 polymorphism and the severity of sedation side effect following desloratadine therapy in patients with CSU. desloratadine 128-141 histamine receptor H1 Homo sapiens 45-49 31406237-7 2020 These results provide evidence that the HRH1 rs901865 G/G polymorphism is associated with severe sedation side effect after desloratadine treatment. desloratadine 124-137 histamine receptor H1 Homo sapiens 40-44 31406237-8 2020 Thus, the HRH1 rs901865 allele may potentially be used as a biomarker for predicting the severity of sedation side effect in patients suffering from CSU and treated with desloratadine. desloratadine 170-183 histamine receptor H1 Homo sapiens 10-14 32406319-1 2020 Desloratadine, a potent antagonist for human histamine H1 receptor, has been revealed to exhibit antihistaminic activity and anti-inflammatory activity. desloratadine 0-13 histamine receptor H1 Homo sapiens 45-66 31274307-0 2019 Route to Prolonged Residence Time at the Histamine H1 Receptor: Growing from Desloratadine to Rupatadine. desloratadine 77-90 histamine receptor H1 Homo sapiens 41-62 31274307-2 2019 We show that both rupatadine (1) and desloratadine (2) have a long residence time at the histamine H1 receptor (H1R). desloratadine 37-50 histamine receptor H1 Homo sapiens 89-110 31274307-2 2019 We show that both rupatadine (1) and desloratadine (2) have a long residence time at the histamine H1 receptor (H1R). desloratadine 37-50 histamine receptor H1 Homo sapiens 112-115 31274307-5 2019 Methylene-linked cycloaliphatic or beta-branched substitutions of desloratadine increase the residence time at the H1R, conveying a longer duration of receptor antagonism. desloratadine 66-79 histamine receptor H1 Homo sapiens 115-118 17577463-2 2007 Desloratadine, a once-daily selective histamine H(1)-receptor antagonist, has been reported to be efficacious in relieving symptoms of SAR in controlled clinical trials. desloratadine 0-13 histamine receptor H1 Homo sapiens 38-61 30863716-2 2019 For alleviation of allergic symptoms, H1R antagonists are therapeutic drugs; of which the most frequently prescribed are second generation drugs, such as; Cetirizine, Loratadine, Hydroxyzine, Desloratadine, Bepotastine, Acrivastine and Rupatadine. desloratadine 192-205 histamine receptor H1 Homo sapiens 38-41 19236123-1 2009 BACKGROUND: Desloratadine is a non-sedating, long-acting histamine H(1) receptor antagonist indicated for the symptomatic relief of allergic rhinitis (AR) and chronic idiopathic urticaria in patients aged>12 years. desloratadine 12-25 histamine receptor H1 Homo sapiens 57-80 17906161-1 2007 Desloratadine, a nonsedating histamine H(1)-receptor antagonist, is metabolized to 3-hydroxy (3-OH) desloratadine. desloratadine 0-13 histamine receptor H1 Homo sapiens 29-52 16259582-1 2005 Desloratadine is a once-daily, non-sedating, non-impairing, selective histamine H1-receptor antagonist. desloratadine 0-13 histamine receptor H1 Homo sapiens 70-91 17298105-2 2007 Desloratadine, a second-generation histamine H(1) receptor antagonist (antihistamine), is a first-line treatment option for CIU. desloratadine 0-13 histamine receptor H1 Homo sapiens 35-58 16970513-1 2006 BACKGROUND AND OBJECTIVES: Desloratadine and levocetirizine are histamine H(1) receptor antagonists (antihistamines) that were launched in the UK in 2001. desloratadine 27-40 histamine receptor H1 Homo sapiens 64-87 15564772-0 2004 Desloratadine inhibits constitutive and histamine-stimulated nuclear factor-kappaB activity consistent with inverse agonism at the histamine H1 Receptor. desloratadine 0-13 histamine receptor H1 Homo sapiens 131-152 15564772-8 2004 CONCLUSIONS: Desloratadine, acting through the histamine H1 receptor, inhibited basal NF-kappaB activity and can thus be classified as an inverse agonist. desloratadine 13-26 histamine receptor H1 Homo sapiens 47-68 12167464-0 2002 Biochemical characterization of desloratadine, a potent antagonist of the human histamine H(1) receptor. desloratadine 32-45 histamine receptor H1 Homo sapiens 80-103 12167464-1 2002 We have characterized desloratadine (5H-benzo[5,6]cyclohepta[1,2-b]pyridine, 8-chloro-6,11-dihydro-11-(4-piperidinylidene), CAS 100643-71-8) as a potent antagonist of the human histamine H(1) receptor. desloratadine 22-35 histamine receptor H1 Homo sapiens 177-200 12167464-2 2002 [3H]Desloratadine bound to membranes expressing the recombinant human histamine H(1) receptor in Chinese hamster ovary cells (CHO-H(1)) in a specific and saturable manner with a K(d) of 1.1+/-0.2 nM, a B(max) of 7.9+/-2.0 pmol/mg protein, and an association rate constant of 0.011 nM(-1) x min(-1). desloratadine 4-17 histamine receptor H1 Homo sapiens 70-93 12167464-4 2002 Dissociation of [3H]desloratadine from the human histamine H(1) receptor was slow, with only 37% of the binding reversed at 6 h in the presence of 5 microM unlabeled desloratadine. desloratadine 20-33 histamine receptor H1 Homo sapiens 49-72 12167464-10 2002 The slow dissociation from the receptor and noncompetitive antagonism suggests that desloratadine may be a pseudoirreversible antagonist of the human histamine H(1) receptor. desloratadine 84-97 histamine receptor H1 Homo sapiens 150-173 12167464-11 2002 The mechanism of desloratadine antagonism of the human histamine H(1) receptor may help to explain the high potency and 24-h duration of action observed in clinical studies. desloratadine 17-30 histamine receptor H1 Homo sapiens 55-78 11243501-5 2001 The novel, nonsedating, histamine H1-receptor antagonist, desloratadine, which exerts various favorable effects on the allergic cascade, significantly decreased SAR symptoms (e.g., nasal congestion) and diminished daily beta2-agonist use and improved asthma symptoms, while maintaining pulmonary function, in patients with SAR-asthma who were treated with once-daily desloratadine regimens. desloratadine 58-71 histamine receptor H1 Homo sapiens 24-45 11243501-5 2001 The novel, nonsedating, histamine H1-receptor antagonist, desloratadine, which exerts various favorable effects on the allergic cascade, significantly decreased SAR symptoms (e.g., nasal congestion) and diminished daily beta2-agonist use and improved asthma symptoms, while maintaining pulmonary function, in patients with SAR-asthma who were treated with once-daily desloratadine regimens. desloratadine 367-380 histamine receptor H1 Homo sapiens 24-45 17523764-0 2005 Predicting and establishing the clinical efficacy of a histamine h(1)-receptor antagonist : desloratadine, the model paradigm. desloratadine 92-105 histamine receptor H1 Homo sapiens 55-78 15168099-2 2004 Desloratadine is a potent, selective, histamine H(1)-receptor antagonist that does not easily cross the blood-brain barrier. desloratadine 0-13 histamine receptor H1 Homo sapiens 38-61 12962522-1 2003 UNLABELLED: Desloratadine (Clarinex, Neoclarityn, Aerius, Azomyr, Opulis, Allex), the principal metabolite of loratadine, is itself an orally active, nonsedating, peripheral histamine H(1)-receptor antagonist. desloratadine 12-25 histamine receptor H1 Homo sapiens 174-197 12492724-1 2002 Desloratadine, a potent, once-daily, orally active, nonsedating, histamine H1-receptor antagonist, inhibits the release of histamine and other inflammatory mediators. desloratadine 0-13 histamine receptor H1 Homo sapiens 65-86 12492727-5 2002 In vitro studies show that desloratadine, a new, once-daily, nonsedating, selective histamine H1-receptor antagonist, blocks the systemic allergy cascade at multiple points. desloratadine 27-40 histamine receptor H1 Homo sapiens 84-105 12492727-8 2002 Unlike many other second-generation histamine H1-receptor antagonists, desloratadine provides the added benefit of efficacy against nasal obstruction in SAR. desloratadine 71-84 histamine receptor H1 Homo sapiens 36-57 12768222-1 2001 A new competitive histamine H(1)-receptor antagonist with superior binding affinity at this receptor as compared with other common antihistamines, desloratadine is the active metabolite of loratadine, the most extensively used agent of this class. desloratadine 147-160 histamine receptor H1 Homo sapiens 18-41 11080746-6 2000 Desloratadine, a new selective histamine H(1)-receptor antagonist with potent antihistaminic and anti-inflammatory activity, is introduced and its potential for treating the systemic aspects of allergic disease is discussed. desloratadine 0-13 histamine receptor H1 Homo sapiens 31-54