PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16741367-3 2006 OBJECTIVE: In this study the capacity of desloratadine and loratadine to counteract human keratinocyte activation by interferon-gamma (IFN-gamma) was analyzed. desloratadine 41-54 interferon gamma Homo sapiens 117-133 16741367-7 2006 RESULTS: Desloratadine and loratadine inhibited the constitutive and IFN-gamma-induced release of CCL5, CXCL8 and CXCL10 from keratinocytes, while the low release of CCL17 remained unchanged. desloratadine 9-22 interferon gamma Homo sapiens 69-78 16741367-9 2006 CONCLUSIONS: The results indicate that desloratadine has the capacity to block the IFN-gamma-induced activation of keratinocytes, and that it can thus exert important regulatory effects on cell-mediated immune responses in the skin. desloratadine 39-52 interferon gamma Homo sapiens 83-92 16741367-3 2006 OBJECTIVE: In this study the capacity of desloratadine and loratadine to counteract human keratinocyte activation by interferon-gamma (IFN-gamma) was analyzed. desloratadine 41-54 interferon gamma Homo sapiens 135-144